Developmental post-natal stress can alter the effects of pre-natal stress on the adult redox balance

Marasco, Valeria; Spencer, Karen A.; Robinson, Jane E.; Herzyk, Paweł

doi:10.1016/j.ygcen.2013.07.003

Cited by 25 publications

(29 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Levels of oxidative stress in the blood have been shown for instance to correlate to those of organs such as heart, muscle or liver, depending on the biomarker used (Veskoukis et al 2009). Blood oxidative stress markers are also known to exhibit similar responses as other organs to manipulations known to induce oxidative stress such as intense physical exercise, exposure to stress hormones, or acute cold exposure (Pereira et al 2013;Marasco et al 2013;Stier et al 2014a, b).…”

Section: Sampling and Laboratory Analysismentioning

confidence: 99%

Environmental conditions can modulate the links among oxidative stress, age, and longevity

Marasco

Stier

Boner

et al. 2017

Mechanisms of Ageing and Development

Self Cite

View full text Add to dashboard Cite

* Joint first authorsHighlights  We exposed zebra finch females to challenging environmental conditions  We examined treatment effects on age-related changes in oxidative stress (OS)  Levels of damage to DNA and proteins increased with chronological age  The treatment produced a higher age-related increase in the level of damage to DNA  We found treatment-specific links among OS and longevity Corresponding author: Pat.Monaghan@glasgow.ac.uk 2 AbstractUnderstanding the links between environmental conditions and longevity remains a major focus in biological research. We examined within-individual changes between early-and midadulthood in the circulating levels of four oxidative stress markers linked to ageing, using zebra finches (Taeniopygia guttata): a DNA damage product (8-hydroxy-2'-deoxyguanosine; 8-OHdG), protein carbonyls (PC), non-enzymatic antioxidant capacity (OXY), and superoxide dismutase activity (SOD). We further examined whether such within-individual changes differed among birds living under control (ad lib food) or more challenging environmental conditions (unpredictable food availability), having previously found that the latter increased corticosterone levels when food was absent but improved survival over a three year period. Our key findings were: (i) 8-OHdG and PC increased with age in both environments, with a higher increase in 8-OHdG in the challenging environment; (ii) SOD increased with age in the controls but not in the challenged birds, while the opposite was true for OXY; (iii) control birds with high levels of 8-OHdG died at a younger age, but this was not the case in challenged birds. Our data clearly show that while exposure to the potentially damaging effects of oxidative stress increases with age, environmental conditions can modulate the pace of this age-related change.

show abstract

Section: Sampling and Laboratory Analysismentioning

confidence: 99%

Environmental conditions can modulate the links among oxidative stress, age, and longevity

Marasco

Stier

Boner

et al. 2017

Mechanisms of Ageing and Development

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, early-life stress is likely to have both benefits and costs. Its potential adaptive outcome may depend on the context within which the phenotypic traits are measured, as well as the life-history stage, the environmental conditions and the generation1461516.…”

mentioning

confidence: 99%

Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail

Zimmer

Larriva

Boogert

et al. 2017

Sci Rep

Self Cite

View full text Add to dashboard Cite

An interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance later in life. These transgenerational effects have been hypothesized to allow individuals to cope better with predictable environmental fluctuations and thus facilitate adaptation to changing environments. Here, we test for the first time how early-life stress drives developmental programming and transgenerational effects of maternal exposure to early-life stress on several phenotypic traits in their offspring in a functionally relevant context using a fully factorial design. We manipulated pre- and/or post-natal stress in both Japanese quail mothers and offspring and examined the consequences for several stress-related traits in the offspring generation. We show that pre-natal stress experienced by the mother did not simply affect offspring phenotype but resulted in the inheritance of the same stress-coping traits in the offspring across all phenotypic levels that we investigated, shaping neuroendocrine, physiological and behavioural traits. This may serve mothers to better prepare their offspring to cope with later environments where the same stressors are experienced.

show abstract

“…Consistent with this prediction, both pre-and postnatal stress experience has been related to variability in adult redox status (Constantini et al, 2012;Marasco et al, 2013;Noguera et al, 2015;Romero-Haro and Alonso-Alvarez, 2015;Zimmer and Spencer, 2015). For instance, following an intense heat stress in adulthood, zebra finches (Taeniopygi guttata) that had been exposed to a mild heat stress as juveniles acquired less oxidative damage than individuals with no prior exposure to heat stress (Constantini et al, 2012).…”

Section: Introductionmentioning

confidence: 81%

“…Similarly, plasticity of oxidative stress resistance and antioxidant defenses has also been observed following prenatal glucocorticoid exposure (Marasco et al, 2013;Zimmer and Spencer, 2015) and limited posthatch nutrient availability (Noguera et al, 2015;Romero-Haro and Alonso-Alvarez, 2015). The apparent priming of redox systems by early life experiences has been suggested to arise through epigenetic modifications of gene expression or post-translational alterations of enzymes (Romero-Haro and Alonso-Alvarez, 2015;Noguera et al, 2015) and may result in context-dependent fitness consequences (Marasco et al, 2013;Constantini et al, 2014;Noguera et al, 2015;Zimmer and Spencer, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…For example, many traits such as body size, growth, locomotor performance, metabolic rate, immune response and early survival are influenced by incubation temperature in reptiles (reviewed by Deeming, 2004;Booth, 2006;DuRant et al, 2013;Bowden et al, 2014). Although the role of developmental environments in shaping many fitness-related traits has received much attention, relatively little work has been conducted to determine how they impact susceptibility to oxidative stress in either vertebrates or invertebrates, despite known consequences of oxidative stress (Metcalfe and Alonso-Alvarez, 2010;Selman et al, 2012;Marasco et al, 2013;Constantini, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Temperature experienced during incubation affects antioxidant capacity but not oxidative damage in hatchling red-eared slider turtles (Trachemys scripta elegans)

Treidel

Carter

Bowden

2015

Journal of Experimental Biology

View full text Add to dashboard Cite

Our understanding of how oxidative stress resistance phenotypes are affected by the developmental environment is limited. One component of the developmental environment, which is likely central to early life oxidative stress among ectothermic and oviparous species, is that of temperature. We investigated how incubation temperature manipulations affect oxidative damage and total antioxidant capacity (TAC) in red-eared slider turtle (Trachemys scripta elegans) hatchlings. First, to determine whether temperature fluctuations elicit oxidative stress, eggs from clutches were randomly assigned to either a constant (29.5°C) or daily fluctuating temperature incubation (28.7±3°C) treatment. Second, to assess the effect of temperature fluctuation frequency on oxidative stress, eggs were incubated in one of three fluctuating incubation regimes: 28.7±3°C fluctuations every 12 h (hyper), 24 h (normal) or 48 h (hypo). Third, we tested the influence of average incubation temperature by incubating eggs in a daily fluctuating incubation temperature regime with a mean temperature of 26.5°C (low), 27.1°C (medium) or 27.7°C (high). Although the accumulation of oxidative damage in hatchlings was unaffected by any thermal manipulation, TAC was affected by both temperature fluctuation frequency and average incubation temperature. Individuals incubated with a low frequency of temperature fluctuations had reduced TAC, while incubation at a lower average temperature was associated with enhanced TAC. These results indicate that although sufficient to prevent oxidative damage, TAC is influenced by developmental thermal environments, potentially because of temperature-mediated changes in metabolic rate. The observed differences in TAC may have important future consequences for hatchling fitness and overwinter survival.

show abstract

Developmental post-natal stress can alter the effects of pre-natal stress on the adult redox balance

Cited by 25 publications

References 54 publications

Environmental conditions can modulate the links among oxidative stress, age, and longevity

Environmental conditions can modulate the links among oxidative stress, age, and longevity

Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail

Temperature experienced during incubation affects antioxidant capacity but not oxidative damage in hatchling red-eared slider turtles (Trachemys scripta elegans)

Contact Info

Product

Resources

About