Developmental plasticity of the hypoxic ventilatory response

Ling, Liming; Olson, E. B.; Vidruk, Edward H.; Mitchell, Gordon S.

doi:10.1016/s0034-5687(97)00091-1

Cited by 86 publications

(103 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reviews are available on selected aspects of respiratory plasticity [e.g., developmental plasticity (80,133), respiratory "memories" (46), time-dependent mechanisms of the hypoxic ventilatory response (8,21,60,117,166,197), serotonergic modulation and plasticity (157), plasticity in the exercise ventilatory response (157,236), and activity-dependent synaptic plasticity (105,193,194)]. Comprehensive reviews focused on selected aspects of respiratory plasticity will appear as a part of this Highlighted Topics series in the Journal of Applied Physiology.…”

mentioning

confidence: 99%

Invited Review: Neuroplasticity in respiratory motor control

Mitchell

Johnson

2003

Journal of Applied Physiology

354

313

View full text Add to dashboard Cite

Although recent evidence demonstrates considerable neuroplasticity in the respiratory control system, a comprehensive conceptual framework is lacking. Our goals in this review are to define plasticity (and related neural properties) as it pertains to respiratory control and to discuss potential sites, mechanisms, and known categories of respiratory plasticity. Respiratory plasticity is defined as a persistent change in the neural control system based on prior experience. Plasticity may involve structural and/or functional alterations (most commonly both) and can arise from multiple cellular/synaptic mechanisms at different sites in the respiratory control system. Respiratory neuroplasticity is critically dependent on the establishment of necessary preconditions, the stimulus paradigm, the balance between opposing modulatory systems, age, gender, and genetics. Respiratory plasticity can be induced by hypoxia, hypercapnia, exercise, injury, stress, and pharmacological interventions or conditioning and occurs during development as well as in adults. Developmental plasticity is induced by experiences (e.g., altered respiratory gases) during sensitive developmental periods, thereby altering mature respiratory control. The same experience later in life has little or no effect. In adults, neuromodulation plays a prominent role in several forms of respiratory plasticity. For example, serotonergic modulation is thought to initiate and/or maintain respiratory plasticity following intermittent hypoxia, repeated hypercapnic exercise, spinal sensory denervation, spinal cord injury, and at least some conditioned reflexes. Considerable work is necessary before we fully appreciate the biological significance of respiratory plasticity, its underlying cellular/molecular and network mechanisms, and the potential to harness respiratory plasticity as a therapeutic tool.

show abstract

mentioning

confidence: 99%

Invited Review: Neuroplasticity in respiratory motor control

Mitchell

Johnson

2003

Journal of Applied Physiology

354

313

View full text Add to dashboard Cite

show abstract

“…Phrenic nerve responses to electrical stimulation of the carotid sinus nerve are virtually identical between hyperoxia-treated and control rats (33,57), suggesting that central integration of chemoafferent inputs is not impaired. On the other hand, normal phrenic responses to carotid sinus nerve stimulation are somewhat surprising because the number of chemoafferent neurons stimulated is reduced in hyperoxia-treated rats (29).…”

Section: Developmental Plasticity In Respiratory Control: Examplesmentioning

confidence: 92%

“…Sheep receiving hyperoxic ventilation (Ͼ24 h) exhibited increased carotid body sensitivity to hypoxia relative to sheep receiving normoxic ventilation. In contrast, prolonged exposure to hyperoxia during the early postnatal period causes life-long impairment of hypoxic responses (4,33,57). In kittens raised in 30% O 2 for the first 12-13 days of life, the acute HVR is abolished immediately following the hyperoxic exposure (43).…”

Section: Developmental Plasticity In Respiratory Control: Examplesmentioning

confidence: 99%

“…The HCVR of adult rats is not altered by perinatal hyperoxia (56), indicating that this plasticity is specific to the hypoxic chemoreflex vs. a more general impairment of the respiratory system. Furthermore, these effects of hyperoxia are unique to development because exposure to similar levels and durations of hyperoxia have no lasting effect on respiratory control if presented after the second postnatal week (6,56,57). The effects of developmental hyperoxia on normoxic ventilation are not consistent across studies, with different groups of rats showing either mild hyperventilation (10,56) or no persistent changes as adults (7,10).…”

Section: Developmental Plasticity In Respiratory Control: Examplesmentioning

confidence: 99%

“…Similarly, Prieto-Lloret et al (81) report that ϳ75% of the CSN fibers and carotid body preparations that respond to increasing extracellular K ϩ fail to respond to hypoxia in adult rats exposed to developmental hyperoxia, suggesting a longlasting loss of O 2 sensitivity in these cells. As a result, adults previously exposed to perinatal hyperoxia exhibit severely attenuated CSN responses to hypoxia (14,33,57,81).…”

Section: Developmental Plasticity In Respiratory Control: Examplesmentioning

confidence: 99%

See 2 more Smart Citations

Long-term effects of the perinatal environment on respiratory control

Bavis¹,

Mitchell²

2008

Journal of Applied Physiology

View full text Add to dashboard Cite

The respiratory control system exhibits considerable plasticity, similar to other regions of the nervous system. Plasticity is a persistent change in system behavior triggered by experiences such as changes in neural activity, hypoxia, and/or disease/injury. Although plasticity is observed in animals of all ages, some forms of plasticity appear to be unique to development (i.e., “developmental plasticity”). Developmental plasticity is an alteration in respiratory control induced by experiences during “critical” developmental periods; similar experiences outside the critical period will have little or no lasting effect. Thus complementary experiments on both mature and developing animals are generally needed to verify that the observed plasticity is unique to development. Frequently studied models of developmental plasticity in respiratory control include developmental manipulations of respiratory gas concentrations (O2 and CO2). Environmental factors not specifically associated with breathing may also trigger developmental plasticity, however, including psychological stress or chemicals associated with maternal habits (e.g., nicotine, cocaine). Despite rapid advances in describing models of developmental plasticity in breathing, our understanding of fundamental mechanisms giving rise to such plasticity is poor; mechanistic studies of developmental plasticity are of considerable importance. Developmental plasticity may enable organisms to “fine tune” their phenotype to optimize the performance of this critical homeostatic regulatory system. On the other hand, developmental plasticity could also increase the risk of disease later in life. Future directions for studies concerning the mechanisms and functional implications of developmental plasticity in respiratory motor control are discussed.

show abstract

Effects of Perinatal Hyperoxia on Breathing

Bavis¹

2020

Comprehensive Physiology

View full text Add to dashboard Cite

Developmental plasticity of the hypoxic ventilatory response

Cited by 86 publications

References 15 publications

Invited Review: Neuroplasticity in respiratory motor control

Invited Review: Neuroplasticity in respiratory motor control

Long-term effects of the perinatal environment on respiratory control

Effects of Perinatal Hyperoxia on Breathing

Contact Info

Product

Resources

About