Developmental Plasticity and Evolution

Paaby, Annalise B.; Testa, Nicholas D.

doi:10.1007/978-3-319-32979-6_110

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…Thus, different abnormal phenotypes may result, which then become fixed due to the reoccurrence of extreme environmental conditions. Furthermore, polyphenic traits may evolve into robust traits if one developmental trajectory is favored over another [81]. In analogy, as proposed by the SETOC, changes in the cellular microenvironment (e.g., oxygen/nutrient deprivation, acidity, temperature) lead to adaptations that result in the uncoupling of the two endosymbiotic cell subsystems (the nucleocytoplasmic system and the mitochondria) toward ancestral or atavistic biologic functions and behaviors that are similar to those of unicellular organisms [16].…”

Section: Atavistic Regression As An Adaptive Response To the Changed ...mentioning

confidence: 99%

Cellular Adaptation Takes Advantage of Atavistic Regression Programs during Carcinogenesis

Gnocchi,

Nikolic,

Paparella

et al. 2023

Cancers

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Adaptation of cancer cells to extreme microenvironmental conditions (i.e., hypoxia, high acidity, and reduced nutrient availability) contributes to cancer resilience. Furthermore, neoplastic transformation can be envisioned as an extreme adaptive response to tissue damage or chronic injury. The recent Systemic–Evolutionary Theory of the Origin of Cancer (SETOC) hypothesizes that cancer cells “revert” to “primitive” characteristics either ontogenically (embryo-like) or phylogenetically (single-celled organisms). This regression may confer robustness and maintain the disordered state of the tissue, which is a hallmark of malignancy. Changes in cancer cell metabolism during adaptation may also be the consequence of altered microenvironmental conditions, often resulting in a shift toward lactic acid fermentation. However, the mechanisms underlying the robust adaptive capacity of cancer cells remain largely unknown. In recent years, cancer cells’ metabolic flexibility has received increasing attention among researchers. Here, we focus on how changes in the microenvironment can affect cancer cell energy production and drug sensitivity. Indeed, changes in the cellular microenvironment may lead to a “shift” toward “atavistic” biologic features, such as the switch from oxidative phosphorylation (OXPHOS) to lactic acid fermentation, which can also sustain drug resistance. Finally, we point out new integrative metabolism-based pharmacological approaches and potential biomarkers for early detection.

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Section: Atavistic Regression As An Adaptive Response To the Changed ...mentioning

confidence: 99%

Cellular Adaptation Takes Advantage of Atavistic Regression Programs during Carcinogenesis

Gnocchi,

Nikolic,

Paparella

et al. 2023

Cancers

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“…A recently-emerged focus on eco-evo-devo seeks to quantitatively understand such ecological causation of developmental evolution 3,4 . Many biotic ecological factors, such as predator-prey [5][6][7] and social interactions [8][9][10] , as well as abiotic factors such as temperature [11][12][13] and oxygen level [14][15][16] are hypothesized or known to play important roles in shaping the evolution of developmental features 4,17 , including developmental plasticity [18][19][20][21][22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

“…The experimental inducibility and facultative character of M. xanthus multicellular development, and its versatility for experimental evolution, make this bacterium a powerful system for investigating the evolution of latent developmental phenotypes. Such phenotypes include the character and degree of phenotypic plasticity, which can be important for fitness and future evolution across variable environments 22,27,70,72 .…”

Section: Introductionmentioning

confidence: 99%

Hidden paths to endless forms most wonderful: Ecology latently shapes evolution of multicellular development in predatory bacteria

Fortezza

Rendueles

Keller

et al. 2021

Preprint

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Ecological causes of developmental-system evolution, for example from predation, remain under intense investigation. An important open question is the role of latent phenotypes in eco-evo-devo. The predatory bacterium Myxococcus xanthus undergoes aggregative multicellular development upon starvation. Here we use M. xanthus to test whether evolution in several distinct growth environments that do not induce development latently alters developmental phenotypes, including morphology and plasticity, in environments that do induce development. In the MyxoEE-3 evolution experiment, growing M. xanthus populations swarmed across agar surfaces while adapting to distinct conditions varying at factors such as surface stiffness or prey identity. All examined developmental phenotypes underwent extensive and ecologically specific latent evolution, with surface stiffness, prey presence and prey identity all strongly impacting the latent evolution of development. Evolution on hard agar allowed retention of developmental proficiency and extensive stochastic phenotypic radiation, including of reaction norms, with instances of both increased plasticity and canalization. In contrast, evolution on soft agar latently led to systematic loss of development, revealing an ecologically-contingent fitness trade-off between the growth and developmental phases of a multicellular life cycle that is likely determined by details of motility behavior. Similar contingency was observed after evolution during predatory growth in distinct prey environments, with Bacillus subtilis causing greater loss of development and lower stochastic diversification than Escherichia coli. Our results have implications for understanding evolutionary interactions among predation, development and motility in myxobacterial life cycles, and, more broadly, the importance of latent phenotypes for the diversification of developmental systems.

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Ontologies in Evolutionary Biology: The Role of the Organism in the Two Syntheses

Cortés-García

Agiriano

2023

Interdisciplinary Evolution Research

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Developmental Plasticity and Evolution

Cited by 3 publications

References 27 publications

Cellular Adaptation Takes Advantage of Atavistic Regression Programs during Carcinogenesis

Cellular Adaptation Takes Advantage of Atavistic Regression Programs during Carcinogenesis

Hidden paths to endless forms most wonderful: Ecology latently shapes evolution of multicellular development in predatory bacteria

Ontologies in Evolutionary Biology: The Role of the Organism in the Two Syntheses

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