Developmental pathways to schizophrenia: Behavioral subtypes.

Abstract

This study examined childhood behavior problems in schizophrenic patients and their healthy siblings. Childhood Behavior Checklist (T. Achenbach, 1991) ratings were obtained from retrospective maternal reports, for 4 age periods: birth to 4 years, 4 to 8 years, 8 to 12 years, and 12 to 16 years. The results indicated that the patients had a variety of childhood behavior problems when compared to their siblings and that the various types of problems differed in their developmental course. Cluster analysis was conducted on the childhood behavior ratings for the schizophrenic patients, and 2 subgroups emerged. Cluster I showed more pronounced behavioral problems than Cluster II, and some of these problems were apparent in early childhood and increased with age. Cluster I also demonstrated greater neuromotor abnormalities in childhood.

The genetic epidemiology of schizophrenia and of schizophrenia spectrum disorders

“…Their actual relationship to schizophrenia may be twofold: -The familial predisposition to schizophrenia is expressed already premorbidly in the guise of subclinical deviations [56]. Prospective studies in children of mothers with schizophrenia (high-risk studies) have shown subclinical motor disabilites, social withdrawal, social anxiety, reduced affective responsivity [57,71], attentional disturbances and reduced information processing capabilities [10] to precede the outcome of schizophrenia or schizotypal personality which was the more likely under the additional influence of stressful life events [10]. -Under the influence of protective factors familial schizophrenia vulnerability may lead to the manifestation not of schizophrenia but of a less severe spectrum condition.…”

Behaviour problems in childhood and adolescence in psychotic offenders: an exploratory study

“…In a retrospective study in which the problem scales of the CBCL were measured, psychomotor poverty and cognitive disorganization were positively related to being 'withdrawn' and negatively related to being 'anxious/depressed' in childhood . Neumann et al (1995) described a group of schizophrenic patients with more pronounced behaviour problems, which had developed in early childhood and increased in severity with age, compared with a group free of such problems. Rossi et al (2000), however, reported that one group of schizophrenic patients initially had few behaviour problems (thought problems and aggressive behaviour), which increased over the years, while in the other group there were serious behaviour problems from the fi rst years of life, but these remained relatively stable until early adulthood.…”

La compromissione del funzionamento sociale precedente l’esordio psicotico

“…Le rimanenti 4 ricerche impiegano i seguenti strumenti: Child Behavior Checklist (CBCL) [18,19], checklist clinica [20], Record of Development and Schooling [21].…”