Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation

Burdan, Franciszek; Pliszczynska-Steuden, Malgorzata; Różyło‐Kalinowska, Ingrid; Chałas, Anna; Różyło, T. Katarzyna; Starosławska, Elżbieta; Klepacz, Robert; Szumiło, Justyna

doi:10.1016/j.reprotox.2011.09.012

Cited by 9 publications

(12 citation statements)

References 33 publications

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“…However, evaluation of mineralisation of the upper two cervical vertebrae was limited only to primary ossification centres, which are relatively big structures. Similar data was also obtained for rat foetuses and pups, prenatally exposed to various selective (DFU; 5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsul- phonyl) phenyl-2(5H)-furanon) and non-selective (ibuprofen, piroxicam, tolmetin) cyclooxygenase inhibitors, but offspring were evaluated on prenatal day 21 and postnatal day 7 th , respectively [5,7]. Even values of the bone density differ from the currently presented ones -probably due to different exposure parameter of X-ray tube -the cranio-caudal mineralisation trend was also revealed.…”

Section: Discussionmentioning

confidence: 53%

“…Animals were acclimated for at least 2 weeks, housed and maintained in an animal care facility, as described before [5,7]. Filtered municipal (Lublin, Poland) tap water and standard laboratory LSM ® rat diet (Agropol; Motycz, Poland) were provided ad libitum.…”

Section: Methodsmentioning

confidence: 99%

“…The lumbar vertebrae were selected since they are relatively large and are not covered by other calcium containing structure on radiographs, like on the cervical, thoracic and sacral level, that are visible on the same level of hyoid, sternum/ribs and hip bones, respectively. Previously described digital radiological method for quantitative bone mineralisation assessment was applied to evaluate morphology and mineralisation of vertebrae [5][6][7]. Radiographs were taken using a self-calibrating digital radiography system (Prostyle Intra X-Ray Unit; Planmeca, Finland), operating at 70 kV and 0.02 mAs with a multiple-use 3 × 4 cm photostimulable storage phosphor plate image receptor.…”

Section: Methodsmentioning

confidence: 99%

“…The most commonly applied one is micro computed tomography (mCT), and various densitometric and classical radiological methods [5,7,14,17,18,25,30,31]. Rarely, micro magnetic resonance (mMR) and positron emission tomography connected with CT (PET-CT) or MR (PET-MR) may be also applied [4].…”

Section: Introductionmentioning

confidence: 99%

“…It was helpful in evaluation of mineralisation of vertebral column in animals exposed in-utero and in an early postnatal period to different xenobiotics, e.g. valproic acid, non-steroidal anti-inflammatory drugs [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

et al. 2016

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Section: Discussionmentioning

confidence: 53%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

et al. 2016

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Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors

Burdan

Starosławska²,

Szumiło

2012

Pharmacological Reports

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Over-the-counter cyclooxygenase inhibitors are used to relief fever and various types of acute pain like headache, toothache, earache, sore throat, as well as postoperative and menstrual ones. They are also major ingredients in cold and flu mixtures. Unlike well-known organ toxicological profile, their prenatal toxicity was not fully established. For a long time, acetaminophen was considered as a relatively safe antipyretic and analgesic drug during pregnancy. However, a new data indicate that it may increase the risk of cryptorchidism and asthma during childhood as well as preeclampsia, preterm birth, maternal phlebothrombosis and pulmonary embolism. Contrary to acetaminophen, non-selective cyclooxygenase inhibitors (non-steroidal anti-inflammatory drugs - NSAID; i.e., diclofenac, ibuprofen, naproxen) may induce intrauterine growth retardation, ductus arteriosus constriction with secondary persistent pulmonary hypertension, reduced fetal renal perfusion that led to oligohydramion, prolonged pregnancy as well as increase prevalence of intracranial bleeding in newborns. Furthermore, a higher risk of miscarriage, stillbirth and some congenital malformations (cardiac and diaphragmatic defects, celosomy - gastroschisis and umbilical hernia) was reported for non-selective inhibitors, in particular high doses of acetylsalicylic acid (aspirin).

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Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

Basal

Ahmed

Mahmoud

et al. 2020

Sci Rep

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Insecticides and other agrochemicals have become indispensable components of the agricultural system to ensure a notable increase in crop yield and food production. As a natural consequence, chemical residues result in significantly increased contamination of both terrestrial and aquatic ecosystems. The present study evaluated the teratogenic, genotoxic, and oxidative stress effects of residual-level lufenuron exposure on pregnant rats during the organogenesis gestational period of both mother and fetus. The tested dams were divided into three groups; control (untreated), low-dose group (orally administered with 0.4 mg/kg lufenuron) and high-dose group (orally administered with 0.8 mg/kg lufenuron). The dams of the two treatment groups showed teratogenic abnormalities represented by the asymmetrical distribution of fetuses in both uterine horns, accompanied by observed resorption sites and intensive bleeding in the uterine horns, whereas their fetuses suffered from growth retardation, morphologic malformations, and skeletal deformations. Histologic examination of the liver and kidney tissues obtained from mothers and fetuses after lufenuron exposure revealed multiple histopathologic changes. DNA fragmentation and cell cycle perturbation were also detected in the liver cells of lufenuron-treated pregnant dams and their fetuses through comet assay and flow cytometry, respectively. Moreover, lufenuron-induced oxidative stress in the liver of mothers and fetuses was confirmed by the increased malondialdehyde levels and decreased levels of enzymatic antioxidants (glutathione peroxidase and superoxide dismutase). Taken together, it can be concluded that lufenuron has a great potential in exerting teratogenic, genotoxic, and oxidative stresses on pregnant rats and their fetuses upon chronic exposure to residual levels during the organogenesis gestational period. The obtained results in the present study imply that women and their fetuses may have the same risk.

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Developmental outcome after exposure to cyclooxygenase inhibitors during pregnancy and lactation

Cited by 9 publications

References 33 publications

Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

Early postnatal development of the lumbar vertebrae in male Wistar rats: double staining and digital radiological studies

Prenatal tolerability of acetaminophen and other over-the-counter non-selective cyclooxygenase inhibitors

Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses

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