Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes

Yang, Lin; Li, Zhenmeiyu; Liu, Shuai; Li, Xiaosu; Yang, Zhengang

doi:10.1007/s12264-021-00759-9

Cited by 37 publications

(85 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LGE consists of subdomains including the dorsal LGE (dLGE) and vLGE (Wen et al, 2021;Yun et al, 2001). The progenitors located in the dLGE contribute to the olfactory bulb (OB) interneurons, whereas vLGE progenitors mainly generate striatal MSNs (Li et al, 2017(Li et al, , 2021Song et al, 2021;Waclaw et al, 2006Waclaw et al, , 2009Xu et al, 2018;Yang et al, 2021a;Zhang et al, 2016). In the Meis2-CKO at E16.5 the dLGE marker Sp8 was expanded ventrally, but the expression of Etv1 (another dLGE marker) was not significantly altered (Fig.…”

Section: Meis2 Is Required For the Differentiation Of The Olfactory B...mentioning

confidence: 99%

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

et al. 2022

Self Cite

View full text Add to dashboard Cite

The striatum is a central regulator of behavior and motor function through the actions of D1 and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic eminence (LGE) progenitor. The molecular mechanisms of cell fate specification of these two neuronal subtypes are incompletely understood. Here, we found that deletion of Meis2, which is highly expressed in the LGE and derivatives led to a large reduction in striatal MSNs due to a block in their differentiation. Meis2 directly binds to the Zfp503 and Six3 promoters and is required for their expression and specification of D1 and D2 MSNs, respectively. Finally, Meis2 expression is regulated by Dlx1/2 at least partially through the enhancer hs599 in the LGE SVZ. Overall, our findings define a pathway in the LGE whereby Dlx1/2 drives expression of Meis2 which subsequently promotes the fate determination of striatal D1 and D2 MSNs via Zfp503 and Six3.

show abstract

Section: Meis2 Is Required For the Differentiation Of The Olfactory B...mentioning

confidence: 99%

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent single‐cell sequencing analyses suggest that EGFR signaling is more likely to be the relevant developmental pathway for the initiation of gliogenesis. EGFR is selectively upregulated in the cortical VZ/SVZ during later embryonic phase (Li et al., 2021; Yang et al., 2021), with its spatiotemporal expression pattern coinciding with the switch from neurogenesis to gliogenesis (Fox & Kornblum, 2005; Kornblum et al., 1997). Previous studies showed that SVZ NPCs expressing low Egfr level differentiate into oligodendrocytes, whereas those expressing high Egfr level differentiate into astrocytes (Burrows et al., 1997).…”

Section: Developmental Origin Of Astrocytesmentioning

confidence: 99%

“…Similarly, in rat postnatal cortex, the proliferation rate of APCs increases from P1 to P10 and then declines gradually (Moroni et al., 2018). In human cortex, a large number of bMIPCs that express EGFR , ASCL1 , and OLIG1/2 are generated at around GW23, and they continue to divide several rounds before they generate APCs (Yang et al., 2021). The APC proliferation probably persists for a long time after birth to keep up with brain growth.…”

Section: Developmental Origin Of Astrocytesmentioning

confidence: 99%

Origin, molecular specification, and stemness of astrocytes

Zheng

Huang

Yang

et al. 2022

Developmental Neurobiology

View full text Add to dashboard Cite

Astrocytes are the most abundant cell type in the central nervous system, carrying out a wide spectrum of biological functions. During early development, neural progenitor cells in the ventricular zone first produce neurons, followed by macroglia in the form of astrocytes or oligodendrocytes. Although the lineage progression of oligodendrocytes has been well understood, the developmental staging of astrocytes has not been defined and the molecular mechanisms underlying their fate specification and differentiation remain largely unknown. The recent advent of sophisticated molecular biology technology, especially single‐cell sequencing, has enabled a deeper understanding of the patterning and molecular specification of astrocyte lineage. Based on the recent single‐cell sequencing data, we provide an up‐to‐date and mechanistic review of the early development and heterogeneity of astrocyte lineage in the developing cortex, and compile a list of stage‐specific markers for astrocyte development. In addition, emerging evidence suggests that under physiological conditions, mature astrocytes are partially specialized progenitor cells that have functionally adapted to local neuronal microenvironment. Under pathological or injury conditions, astrocytes are capable of reentering cell cycles and differentiating into other neural cell types under the influence of both intrinsic factors and environmental cues.

show abstract

“…Despite this challenge, recent progresses have been made in our understanding of the generation of cortical astrocyte diversity in the human brain. By combining analysis of published human cortical single-cell RNA-Seq datasets with immunostainings performed on human fetal brain samples collected around mid-gestation, Yang and collaborators showed that cortical astrocytes, along with oligodendrocytes and olfactory bulb interneurons, were born from basal multipotent intermediate progenitors (bMIPCs) expressing EGFR, ASCL1, OLIG2, and OLIG1 ( Yang et al, 2022 ). Interestingly these bMIPCs are also found in the mouse brain ( Li et al, 2021 ) and thus seems to be a common feature of cortical astrocyte development from these two species.…”

Section: Discussionmentioning

confidence: 99%

Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation

2022

View full text Add to dashboard Cite

In the mammalian brain, astrocytes form a heterogeneous population at the morphological, molecular, functional, intra-, and inter-region levels. In the past, a few types of astrocytes have been first described based on their morphology and, thereafter, according to limited key molecular markers. With the advent of bulk and single-cell transcriptomics, the diversity of astrocytes is now progressively deciphered and its extent better appreciated. However, the origin of this diversity remains unresolved, even though many recent studies unraveled the specificities of astroglial development at both population and individual cell levels, particularly in the cerebral cortex. Despite the lack of specific markers for each astrocyte subtype, a better understanding of the cellular and molecular events underlying cortical astrocyte diversity is nevertheless within our reach thanks to the development of intersectional lineage tracing, microdissection, spatial mapping, and single-cell transcriptomic tools. Here we present a brief overview describing recent findings on the genesis and maturation of astrocytes and their key regulators during cerebral cortex development. All these studies have considerably advanced our knowledge of cortical astrogliogenesis, which relies on a more complex mode of development than their neuronal counterparts, that undeniably impact astrocyte diversity in the cerebral cortex.

show abstract

Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes

Cited by 37 publications

References 109 publications

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum

Origin, molecular specification, and stemness of astrocytes

Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation

Contact Info

Product

Resources

About