Developmental Origins of Breast Cancer: A Paternal Perspective

Fontelles, Camile Castilho; Cruz, Raquel Santana da; Hilakivi‐Clarke, Leena; Assis, Sônia de; Ong, Thomas Prates

doi:10.1007/978-1-4939-7614-0_5

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…There are specific windows of susceptibility to epigenetic changes by environmental exposures during sperm development, including the intrauterine period, prepuberty, and the reproductive and zygotic phases of the man (SOUBRY et al, 2014;FONTELLES et al, 2018a…”

Section: Paternal Programmingmentioning

confidence: 99%

“…Currently it is recognized that the origin of some diseases occurs during early development, a theory known as Developmental Origins of Health and Disease (DOHaD) (ARIS; FLEISCH; OKEN, 2018). Although this theory has been investigated mostly from a maternal perspective, recent evidence highlights a potential role of fathers in this context (FONTELLES et al, 2018a). It was demonstrated that paternal under or overnutrition can induce metabolic dysfunction (MCPHERSON et al, 2016;MAGNUS et al, 2018;NG et al, 2010) and increase susceptibility to breast cancer development in female offspring (FONTELLES et al, 2016b;DA CRUZ et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

Silva¹

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SILVA, L. B. A. R. Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk. 2019. 90 p. Thesis (PhD)-Faculty of Pharmaceutical Sciences, University of São Paulo. Breast cancer is the most frequent cancer in women worldwide. Paternal consumption of a highfat diet has been shown to program breast cancer risk in female offspring. Orange juice is widely consumed and is known for its content of bioactive compounds that may have a role in regulating epigenetic processes. Therefore, the aim of the present study was to evaluate the effects of paternal obesity and orange juice consumption on female offspring susceptibility to chemically-induced breast carcinogenesis. Three-week-old C57BL/6 male mice were distributed in control (CO), control-orange juice (CJ), obese (OB) and obese-orange juice (OJ) groups, fed either a standard chow or a high-fat/high-sugar diet (45% lard-based diet supplemented with sweetened condensed milk), with water or orange juice, for 11 weeks before mating. Female offspring were weaned onto standard chow until 7 weeks of age and then were initiated with 7,12-dimethyl-benzo[a]anthracene to induce mammary tumors. CJ female offspring presented higher multiplicity of mammary tumors (p£0.05) compared to CO offspring. Female offspring from OB group showed higher tumor latency (p£0.05), lower tumor incidence (p£0.05), higher multiplicity of tumors (p£0.05), lower cell proliferation (Ki67) in the mammary ducts (p£0.05) and lower global levels of H3K27me3 in the mammary gland (p£0.05) when compared to CO offspring. No differences (p³0,05) were observed between OB and OJ female offspring regarding these parameters. Consumption of orange juice by non-obese fathers during preconception increased susceptibility of female offspring to mammary carcinogenesis. Although paternal consumption of a high-fat/high-sugar diet during preconception decreased incidence and increased latency of tumors, the multiplicity of lesions increased. In addition, the data indicates that the response to orange juice consumption depends of the paternal metabolic context.

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Section: Paternal Programmingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

Silva¹

View full text Add to dashboard Cite

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Bioactive food compounds, epigenetics and chronic disease prevention: Focus on early-life interventions with polyphenols

Silva

Pinheiro-Castro

Novaes

et al. 2019

Food Research International

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Evidence for familial clustering in breast cancer age of onset

Holle

O’Brien

Sandler

et al. 2020

International Journal of Epidemiology

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Background Familial clustering of age at onset would have implications for both personalized screening and aetiology, but has not been studied for breast cancer. Methods We prospectively studied a cohort of 23 145 sisters to explore whether their breast cancer risk changed near the age at diagnosis of a previously affected older sister. Using an age-time-dependent variable in a Cox regression model, we estimated hazard ratios for breast cancer when participants were near their sister’s diagnosis age, relative to similarly aged women whose sister was diagnosed at a very different age. To rule out a correlation driven by young-onset familial cancer, we separately investigated women who had enrolled at age 50 or older. Results Of the 23 145 women, 1412 developed breast cancer during follow-up (median 9.5 years). The estimated hazard ratio was 1.80 (95% confidence interval: 1.18, 2.74) at their sister’s age at diagnosis, suggesting a substantial increase in risk compared with women of the same age but whose sister was diagnosed at a very different age. Restriction to women who enrolled at or after age 50 produced similar results. Conclusions This familial clustering suggests that there may be important genetic and/or early environmental risk factors that influence the timing of breast cancer, even when onset is late in life. Personalized screening might need to account for the age at which a sister was earlier diagnosed with breast cancer.

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Developmental Origins of Breast Cancer: A Paternal Perspective

Cited by 4 publications

References 84 publications

Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

Influence of paternal consumption of a high-fat/high-sugar diet and/or orange juice during preconception on C57BL/6 female mice offspring breast cancer risk

Bioactive food compounds, epigenetics and chronic disease prevention: Focus on early-life interventions with polyphenols

Evidence for familial clustering in breast cancer age of onset

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