Developmental or Procedural Vena Cava Interruption and Venous Thromboembolism: A Review

Abstract

The inferior vena cava (IVC) and superior vena cava are the main conduits of the systemic venous circulation into the right atrium. Developmental or procedural interruptions of vena cava might predispose to stasis and deep vein thrombosis (DVT) distal to the anomaly and may impact the subsequent rate of pulmonary embolism (PE). This study aimed to review the various etiologies of developmental or procedural vena cava interruption and their impact on venous thromboembolism. A systematic search was performed in PubMed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines per each clinical question. For management questions with no high-quality evidence and no mutual agreements between authors, Delphi methods were used. IVC agenesis is the most common form of congenital vena cava interruption, is associated with an increased risk of DVT, and should be suspected in young patients with unexpected extensive bilateral DVT. Surgical techniques for vena cava interruption (ligation, clipping, and plication) to prevent PE have been largely abandoned due to short-term procedural risks and long-term complications, although survivors of prior procedures are occasionally encountered. Vena cava filters are now the most commonly used method of procedural interruption, frequently placed in the infrarenal IVC. The most agreed-upon indication for vena cava filters is for patients with acute venous thromboembolism and coexisting contraindications to anticoagulation. Familiarity with different forms of vena cava interruption and their local and systemic adverse effects is important to minimize complications and thrombotic events.

Recent Advances in Thrombosis and Hemostasis—Part X

“…A very large group of authors, led by Behnood Bikdeli, has systematically reviewed the entire literature on congenital and acquired vena cava interruptions. 8 They address both epidemiology and management, complementing the latter part with a Delphi process. One important conclusion is that a young patient presenting with bilateral leg vein thrombosis should be suspected to have agenesis of the inferior vena cava.…”

Inferior Vena Cava Filters: A Clinical Review and Future Perspectives

“…This procedure was associated with a high success rate (95.2%, 95% CI, 89.9–98.2%, p = 0.02) and a low rate (4%, 95% CI, 1.3–9.0, p = 0.01) of major complications, defined as any adverse event associated with morbidity or disability or resulting in hospital admission. However, the standard snare technique remains at the moment the first choice for filter retrieval, as “advanced” techniques, such as the laser sheath technique, should be performed only in selected cases and by expert operators [ 86 ].…”