Developmental Neurotoxicity of Antiepileptic Drugs

Hansen, Deborah K.; Holson, R.Robert

doi:10.1016/b978-012648860-9.50046-7

Cited by 3 publications

(9 citation statements)

References 154 publications

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“…Activity changes (hyperactivity) are also prominent in rats after gestational phenytoin exposure (Vorhees, 1987b;Vorhees and Minck, 1989;Weisenburger et al, 1990;Tachibana et al, 1996;McCartney et al, 1999;Schilling et al, 1999). A striking spontaneous circling behavior has also been observed in some, but not all, animals, which has been suggested to be due to a midear problem, although this has not been confirmed (Hansen and Holson, 1998). Overall, these data suggest that phenytoin can cause abnormalities within the auditory-vestibular cerebellar system and likely the hippocampus (Hansen and Holson, 1998).…”

Section: B Antiepileptic Drugsmentioning

confidence: 78%

“…A striking spontaneous circling behavior has also been observed in some, but not all, animals, which has been suggested to be due to a midear problem, although this has not been confirmed (Hansen and Holson, 1998). Overall, these data suggest that phenytoin can cause abnormalities within the auditory-vestibular cerebellar system and likely the hippocampus (Hansen and Holson, 1998). Cerebellar damage has been found in mice after administration of phenytoin during the neonatal period (Ohmori et al, 1992(Ohmori et al, , 1997, but no information exists on hippocampal effects.…”

Section: B Antiepileptic Drugsmentioning

confidence: 92%

“…Perinatal exposure to phenobarbital in rats and mice causes decrements in spatial learning task including the radial eight-arm maze, the Morris water maze, and spontaneous alternation (Table 5) (Kleinberger and Yanai, 1985;Pick and Yanai, 1985;Rogel-Fuchs et al, 1992). Limited data exist on the potential effects of phenobarbital on motor activity, which may be expected given the cerebellar damage observed (Hansen and Holson, 1998).…”

Section: B Antiepileptic Drugsmentioning

confidence: 98%

“…These drugs have been found to cause major malformations, microcephaly, growth retardation, and distinctive minor abnormalities of the face and fingers in infants following prenatal exposure (Hanson and Smith, 1975;Seip, 1976;Winter et al, 1987;Jones et al, 1989). In some cases, such as with phenobarbital and phenytoin, extensive animal studies have documented major developmental effects, as well as more subtle neurofunctional and behavioral abnormalities (Hansen and Holson, 1998). On the other hand, long-term follow-up of children exposed to antiepileptic drugs in utero has been more limited, so relatively little is known about the subsequent neurological and cognitive development of these children (Adab et al, 2001).…”

Section: B Antiepileptic Drugsmentioning

confidence: 99%

“…Unlike phenobarbital and phenytoin, limited information exists on the effects of valproic acid on the developing brain at doses that do not induce severe teratogenesis (Hansen and Holson, 1998). Early postnatal exposure was found to decrease brain weight in mice (Thurston et al, 1981), whereas gestational exposure in rats was reported to cause membrane order abnormalities .…”

Section: B Antiepileptic Drugsmentioning

confidence: 99%

See 4 more Smart Citations

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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Section: B Antiepileptic Drugsmentioning

confidence: 78%

Section: B Antiepileptic Drugsmentioning

confidence: 92%

Section: B Antiepileptic Drugsmentioning

confidence: 98%

Section: B Antiepileptic Drugsmentioning

confidence: 99%

Section: B Antiepileptic Drugsmentioning

confidence: 99%

See 3 more Smart Citations

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

2004

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Developmental Neuropathology of Environmental Agents

Costa

Aschner

Vitalone

et al. 2004

Annu. Rev. Pharmacol. Toxicol.

312

168

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The developing central nervous system (CNS) is more vulnerable to injury than the adult one. Although a great deal of research has been devoted to subtle effects of developmental exposure, such as neurobehavioral changes, this review instead focuses on a number of chemicals that have been shown, in several experimental models as well as humans, to cause morphological changes in the developing nervous system. Chemicals that are discussed include methylmercury (MeHg), lead (Pb), antiepileptic drugs, and ethanol. Additionally, the issue of silent neurotoxicity, i.e., persistent morphological and/or biochemical injury that remains clinically unapparent until later in life, is discussed.

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Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary.

Adams

Barone

LaMantia

et al. 2000

Environ Health Perspect

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This paper summarizes the deliberations of a work group charged with addressing specific questions relevant to risk estimation in developmental neurotoxicology. We focused on eight questions. a) Does it make sense to think about discrete windows of vulnerability in the development of the nervous system? If it does, which time periods are of greatest importance? b) Are there cascades of developmental disorders in the nervous system? For example, are there critical points that determine the course of development that can lead to differences in vulnerabilities at later times? c) Can information on critical windows suggest the most susceptible subgroups of children (i.e., age groups, socioeconomic status, geographic areas, race, etc.)? d) What are the gaps in existing data for the nervous system or end points of exposure to it? e) What are the best ways to examine exposure-response relationships and estimate exposures in vulnerable life stages? f) What other exposures that affect development at certain ages may interact with exposures of concern? g) How well do laboratory animal data predict human response? h) How can all of this information be used to improve risk assessment and public health (risk management)? In addressing these questions, we provide a brief overview of brain development from conception through adolescence and emphasize vulnerability to toxic insult throughout this period. Methodological issues focus on major variables that influence exposure or its detection through disruptions of behavior, neuroanatomy, or neurochemical end points. Supportive evidence from studies of major neurotoxicants is provided. Key words: abnormal neurological development, behavioral teratology, behavioral testing methodology, delayed neurotoxicity, developmental disorders, developmental neurotoxicology, environmental health, neurobiological substrates of function, neuronal plasticity. -Environ Health Perspect 1 08(suppl 3): 535-544 (2000). http.//ehpnetl.niehs.nih.gov/docs/2000/suppl-3/535-544adams/abstract.html

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Developmental Neurotoxicity of Antiepileptic Drugs

Cited by 3 publications

References 154 publications

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

Developmental Neuropathology of Environmental Agents

Workshop to identify critical windows of exposure for children's health: neurobehavioral work group summary.

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