Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip

Hoffmeister, Meike; Krieg, Julia; Ehrke, Alexander; Seigfried, Franziska A.; Wischmann, Lisa; Dietmann, Petra; Kühl, Susanne J.; Oess, Stefanie

doi:10.1016/j.ydbio.2017.06.026

Cited by 13 publications

(45 citation statements)

References 64 publications

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“…Functionality and efficiency of the Nosip MO were already shown earlier by immunoblotting (Hoffmeister et al, 2017). Functionality and efficiency of the Nosip MO were already shown earlier by immunoblotting (Hoffmeister et al, 2017).…”

Section: Knockdown Of Nosip Affects Proper Xenopus Eye Developmentmentioning

confidence: 68%

“…Loss of Nosip leads to severe defects during murine craniofacial development (Hoffmeister et al, 2014). Furthermore, Nosip-depleted mouse and Xenopus embryos show microcephaly and down-regulation of Rbp1 (retinol binding protein 1) at protein and mRNA level (Hoffmeister et al, 2017). In addition, Nosip-deficiency in mouse and Xenopus interferes with cell proliferation and apoptosis in the early neural tissue (Hoffmeister et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, Nosip-depleted mouse and Xenopus embryos show microcephaly and down-regulation of Rbp1 (retinol binding protein 1) at protein and mRNA level (Hoffmeister et al, 2017). In addition, Nosip-deficiency in mouse and Xenopus interferes with cell proliferation and apoptosis in the early neural tissue (Hoffmeister et al, 2017). Especially for these craniofacial defects observed in the mouse, the underlying molecular mechanisms are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Nosip-deficiency in mouse and Xenopus interferes with cell proliferation and apoptosis in the early neural tissue (Hoffmeister et al, 2017). First expression studies indicate a specific nosip expression in the developing eye and pharyngeal arches of Xenopus (Hoffmeister et al, 2017), but it is still unclear whether Nosip plays a role during the development of these tissues in Xenopus. First expression studies indicate a specific nosip expression in the developing eye and pharyngeal arches of Xenopus (Hoffmeister et al, 2017), but it is still unclear whether Nosip plays a role during the development of these tissues in Xenopus.…”

Section: Introductionmentioning

confidence: 99%

“…Using a specific antisense morpholino oligonucleotide (MO) knock down approach (Hoffmeister et al, 2017), we demonstrated an eye phenotype including microphthalmia, coloboma and defective retinal lamination in Nosip-depleted Xenopus embryos. First, we confirmed the requirement of Nosip in the developing murine eye.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Nosip functions during vertebrate eye and cranial cartilage development

Flach

Krieg

Hoffmeister

et al. 2018

Developmental Dynamics

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Section: Knockdown Of Nosip Affects Proper Xenopus Eye Developmentmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Nosip functions during vertebrate eye and cranial cartilage development

Flach

Krieg

Hoffmeister

et al. 2018

Developmental Dynamics

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Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Grozdanov

Bousset²,

Hoffmeister

et al. 2019

Annals of Neurology

117

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ObjectiveExcessive inflammation in the central nervous system (CNS) and the periphery can result in neurodegeneration and parkinsonism. Recent evidence suggests that immune responses in Parkinson disease patients are dysregulated, leading to an increased inflammatory reaction to unspecific triggers. Although α‐synuclein pathology is the hallmark of Parkinson disease, it has not been investigated whether pathologic α‐synuclein is a specific trigger for excessive inflammatory responses in Parkinson disease.MethodsWe investigated the immune response of primary human monocytes and a microglial cell line to pathologic forms of α‐synuclein by assessing cytokine release upon exposure.ResultsWe show that pathologic α‐synuclein (mutations, aggregation) results in a robust inflammatory activation of human monocytes and microglial BV2 cells. The activation is conformation‐ dependent, with increasing fibrillation and early onset mutations having the strongest effect on immune activation. We also found that activation of immune cells by extracellular α‐synuclein is potentiated by extracellular vesicles, possibly by facilitating the uptake of α‐synuclein. Blood extracellular vesicles from Parkinson disease patients induce a stronger activation of monocytes than blood extracellular vesicles from healthy controls. Most importantly, monocytes from Parkinson disease patients are dysregulated and hyperactive in response to stimulation with pathologic α‐synuclein. Furthermore, we demonstrate that α‐synuclein pathology in the CNS is sufficient to induce the monocyte dysregulation in the periphery of a mouse model.InterpretationTaken together, our data suggest that α‐synuclein pathology and dysregulation of monocytes in Parkinson disease can act together to induce excessive inflammatory responses to α‐synuclein. ANN NEUROL 2019;86:593–606

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Retinol binding protein 1 affects Xenopus anterior neural development via all‐trans retinoic acid signaling

Flach

Basten

Schreiner

et al. 2021

Developmental Dynamics

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Background: Retinol binding protein 1 (Rbp1) acts as an intracellular regulator of vitamin A metabolism and retinoid transport. In mice, Rbp1 deficiency decreases the capacity of hepatic stellate cells to take up all-trans retinol and sustain retinyl ester stores. Furthermore, Rbp1 is crucial for visual capacity. Although the function of Rbp1 has been studied in the mature eye, its role during early anterior neural development has not yet been investigated in detail. Results: We showed that rbp1 is expressed in the eye, anterior neural crest cells (NCCs) and prosencephalon of the South African clawed frog Xenopus laevis. Rbp1 knockdown led to defects in eye formation, including microphthalmia and disorganized retinal lamination, and to disturbed induction and differentiation of the eye field, as shown by decreased rax and pax6 expression. Furthermore, it resulted in reduced rax expression in the prosencephalon and affected cranial cartilage. Rbp1 inhibition also interfered with neural crest induction and migration, as shown by twist and slug. Moreover, it led to a significant reduction of the all-trans retinoic acid target gene pitx2 in NCC-derived periocular mesenchyme. The Rbp1 knockdown phenotypes were rescued by pitx2 RNA co-injection. Conclusion: Rbp1 is crucial for the development of the anterior neural tissue.

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Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip

Abstract: Nosip is a novel factor critical for neural stem cell/progenitor self-renewal and neurogenesis during mouse and Xenopus development and functions upstream of Rbp1 during early neurogenesis.

Cited by 13 publications

References 64 publications

Nosip functions during vertebrate eye and cranial cartilage development

Nosip functions during vertebrate eye and cranial cartilage development

Increased Immune Activation by Pathologic α‐Synuclein in Parkinson's Disease

Retinol binding protein 1 affects Xenopus anterior neural development via all‐trans retinoic acid signaling

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