2018
DOI: 10.1016/j.ntt.2018.04.001
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Abstract: Developmental stress, including low socioeconomic status (SES), can induce dysregulation of the hypothalamic-pituitary-adrenal axis and result in long-term changes in stress reactivity. Children in lower SES households experience more stress and are more likely to be exposed to environmental neurotoxins such as lead (Pb) and manganese (Mn) than children in higher SES households. Co-exposure to stress, Pb, and Mn during early development may increase the risk of central nervous system dysfunction compared with … Show more

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Cited by 25 publications
(14 citation statements)
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“…This result indicates that Pb treatment may have affected the ability of the animals to learn or remember the location of the dark box earlier than expected after several trial period. This finding supported several earlier reports that implicated Pb EAHT exposure as an agent of cognitive impairment, particularly in a developing brain [13,[33][34][35]. This result further indicates that the treatment of Vitexin alongside Pb treatment will attenuate the possible cognitive impairment caused by Pb.…”
Section: Discussionsupporting
confidence: 91%
“…This result indicates that Pb treatment may have affected the ability of the animals to learn or remember the location of the dark box earlier than expected after several trial period. This finding supported several earlier reports that implicated Pb EAHT exposure as an agent of cognitive impairment, particularly in a developing brain [13,[33][34][35]. This result further indicates that the treatment of Vitexin alongside Pb treatment will attenuate the possible cognitive impairment caused by Pb.…”
Section: Discussionsupporting
confidence: 91%
“…Performance in the CWM is largely mediated by dopamine since dopamine lesions of the striatum with 6-hydroxydopamine induce large learning deficits 25,48,49 . Drugs, pesticides, or metals that target the striatum also produce deficits in the CWM [50][51][52][53][54][55] . This is the first study to show long-term deficits in the CWM following irradiation.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, DA receptor upregulation that might result from reduced DA efflux cannot simply account for the lasting reductions in DA outflow in the STR. Other investigators examined elevated Mn exposure during early development in rats, measuring regional brain biogenic amine concentrations (Amos- Kroohs et al, 2016;Bailey et al, 2019;Sprowles et al, 2018;Vorhees et al, 2014). Results with those endpoints cannot be directly compared with the evoked outflow in extracellular fluid produced by microdialysis, but it is apparent in those studies that NE and DA are most sensitive to elevated Mn exposure and that in general, Mn-induced alterations in brain NE/DA concentrations observed in early development do not persist into adulthood.…”
Section: Discussionmentioning
confidence: 99%