Developmental Immunity: From Birth to Adult

Urschel, Simon; West, Lori J.

doi:10.1002/9781118873434.ch112

Cited by 1 publication

(2 citation statements)

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“…Compared to solid organ system development where anatomy and functionality near mature stages by the end of gestation, the immune system is incompletely formed and subject to major developmental changes throughout childhood [38]. Considered individually, a number of features of the young immune system could be implicated in the favorable transplant outcomes reported or have the potential to be exploited for beneficial impact on transplantation [39], while other features such as vaccination status and lack of infectious exposures (i.e.…”

Section: Immunologic Considerationsmentioning

confidence: 99%

“…However, as with other IgG isotype antibodies, those directed against HLA epitopes are subject to transplacental transfer and can lead to passive presence of HLA antibodies in the newborn that may persists up to 18 months of age [40]. Therefore, assessment of neonatal sensitization can be difficult and may only be confirmed by documenting the course and natural decline of the maternal antibodies relative to the infant's own immune response [38]. Unique pathologies in pediatrics often require early interventions that result in immunologic alternations that are different than those seen in adult populations.…”

Section: Immunologic Considerationsmentioning

confidence: 99%

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Optimizing the pediatric transplant candidate

Squires,

Raghu,

Mazariegos

2023

Current Opinion in Organ Transplantation

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Purpose of review Advances in pediatric transplant parallel those in adult populations; however, there remain critical unique considerations and differences that require specialized knowledge and a specific skill set to optimize care afforded to the pediatric transplant candidate. We introduce general themes regarding optimization of the transplant candidate that are unique to children. Recent findings The pathologies leading to pediatric organ transplant candidacy differ from adults and a precise understanding of the physiologies and natural histories of such diseases is critical for optimized care. Regardless of etiology, comorbidities including malnutrition, sarcopenia, and developmental delay are seen and often require disease and organ specific approaches to management. Additionally, an understanding of the concepts of developmental immunology and their relevance to transplant is critical. Summary When looking to optimize pretransplant care, awareness of the pediatric-specific challenges by the transplant community in addition to organ- and age-specific management strategies enable the best outcomes for children awaiting solid organ transplantation.

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Section: Immunologic Considerationsmentioning

confidence: 99%

Section: Immunologic Considerationsmentioning

confidence: 99%