Developmental Gene Regulation by an Ancient Intercellular Communication System in Social Amoebae

Asghar, Asma; Groth, Marco; Siol, Oliver; Gaube, Friedemann; Enzensperger, Christoph; Glöckner, Gernot; Winckler, Thomas

doi:10.1016/j.protis.2010.12.002

Cited by 26 publications

(46 citation statements)

References 23 publications

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“…Acrasins (like cAMP), e.g., glorin 15 (Fig. 3C), which are implicated in the aggregation of slime molds (not specifically physarum) also have certain structural similarities to compounds found in valerian.…”

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confidence: 99%

Physarum attraction: Why slime mold behaves as cats do?

Adamatzky

Costello

2012

Communicative & Integrative Biology

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confidence: 99%

Physarum attraction: Why slime mold behaves as cats do?

Adamatzky

Costello

2012

Communicative & Integrative Biology

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“…Asghar et al . [31] recently reported that four group 1 and nine clade 2B species showed chemotaxis to glorin, but none of three tested group 4 species. Their choice of species partially overlaps with ours, and both studies confirm each others results.…”

Section: Resultsmentioning

confidence: 99%

“…Its spores were elliptical and contained polar granules (see the electronic supplementary material, figure S6 a ). It used cAMP to coordinate fruiting body morphogenesis (see the electronic supplementary material, figure S6 p ), but not aggregation (see the electronic supplementary material, figure S6 o ), which may have been mediated by glorin (see the electronic supplementary material, figure S6 n ; [31]).…”

Section: Resultsmentioning

confidence: 99%

Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity

et al. 2013

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Colony formation was the first step towards evolution of multicellularity in many macroscopic organisms. Dictyostelid social amoebas have used this strategy for over 600 Myr to form fruiting structures of increasing complexity. To understand in which order multicellular complexity evolved, we measured 24 phenotypic characters over 99 dictyostelid species. Using phylogenetic comparative methods, we show that the last common ancestor (LCA) of Dictyostelia probably erected small fruiting structures directly from aggregates. It secreted cAMP to coordinate fruiting body morphogenesis, and another compound to mediate aggregation. This phenotype persisted up to the LCAs of three of the four major groups of Dictyostelia. The group 4 LCA co-opted cAMP for aggregation and evolved much larger fruiting structures. However, it lost encystation, the survival strategy of solitary amoebas that is retained by many species in groups 1–3. Large structures, phototropism and a migrating intermediate ‘slug’ stage coevolved as evolutionary novelties within most groups. Overall, dictyostelids show considerable plasticity in the size and shape of multicellular structures, both within and between species. This probably reflects constraints placed by colonial life on developmental control mechanisms, which, depending on local cell density, need to direct from 10 to a million cells into forming a functional fructification.

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“…Remarkably, in groups 1 and 2, cAR1 orthologs are only expressed after aggregation (74), and in either group 1, 2, or 3, abrogation of cAR function disrupts slug and fruiting body formation, but not aggregation (75). The latter effect was not unexpected, since group 1–3 species use other attractants than cAMP to aggregate, with glorin being most prevalent (76). However, the fact that postaggregative morphogenesis is blocked by loss of cAR function suggests that all Dictyostelia use oscillatory cAMP signaling to coordinate cell movement during slug and fruiting body formation.…”

Section: Classification Of Amoebozoamentioning

confidence: 94%

The Amoebozoa

Schilde

Schaap²

2013

Methods in Molecular Biology

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The model organism Dictyostelium discoideum is a member of the Amoebozoa, one of the six major divisions of eukaryotes. Amoebozoa comprise a wide variety of amoeboid and flagellate organisms with single cells measuring from 5 μm to several meters across. They have adopted many different life styles and sexual behaviors and can live in all but the most extreme environments. This chapter provides an overview of Amoebozoan diversity and compares roads towards multicellularity within the Amoebozoa with inventions of multicellularity in other protist divisions. The chapter closes with a scenario for the evolution of Dictyostelid multicellularity from an Amoebozoan stress response.

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Developmental Gene Regulation by an Ancient Intercellular Communication System in Social Amoebae

Cited by 26 publications

References 23 publications

Physarum attraction: Why slime mold behaves as cats do?

Physarum attraction: Why slime mold behaves as cats do?

Analysis of phenotypic evolution in Dictyostelia highlights developmental plasticity as a likely consequence of colonial multicellularity

The Amoebozoa

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