Developmental forebrain cholinergic lesion and environmental enrichment: Behaviour, CA1 cytoarchitecture and neurogenesis

Fréchette, Mylène; Rennie, Kerry; Pappas, Bruce A.

doi:10.1016/j.brainres.2008.11.082

Cited by 32 publications

(30 citation statements)

References 69 publications

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“…Previous EC paradigms have exposed animals to EC housing without exposure to WR 12,50 , WR inside of the EC cage for a shorter amount of time 51 or with less animals 52 , or the animals were exposed to an EC environment for a longer amount of time with less frequent changing of cage items 13 . It is likely that the beneficial effects of EC require the induced plasticity from WR in a temporally relevant time window to show long-term benefit.…”

Section: Discussionmentioning

confidence: 99%

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Gursky

Klintsova

2017

JoVE

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Aerobic exercise (e.g., wheel running (WR) extensively used in animal research) positively impacts many measures of neuroplastic potential in the brain, such as rates of adult neurogenesis, angiogenesis, and expression of neurotrophic factors in rodents. This intervention has also been shown to mitigate behavioral and neuroanatomical aspects of the negative impacts of teratogens (i.e., developmental exposure to alcohol) and age-related neurodegeneration in rodents. Environmental complexity (EC) has been shown to produce numerous neuroplastic benefits in cortical and subcortical structures and can be coupled with wheel running to increase the proliferation and survival of new cells in the adult hippocampus. The combination of these two interventions provides a robust "superintervention" (WR-EC) that can be implemented in a range of rodent models of neurological disorders. We will discuss the implementation of WR/EC and its constituent interventions for use as a more powerful therapeutic intervention in rats using the animal model of prenatal exposure to alcohol in humans. We will also discuss which elements of the procedures are absolutely necessary for the interventions and which ones may be altered depending on the experimenter's question or facilities.

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Section: Discussionmentioning

confidence: 99%

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Gursky

Klintsova

2017

JoVE

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“…Our data suggest that EE may compensate the ACh depletion in the hippocampus of Ts65Dn mice [78], by increasing the efficiency of their signal transduction system [86], but is also increasing calcium-stimulated PIP 2 hydrolysis thus suggesting that the impact of EE could be broader increasing signaling through other neurotransmitter systems as well.…”

Section: Discussionmentioning

confidence: 99%

G-Protein-Associated Signal Transduction Processes Are Restored after Postweaning Environmental Enrichment in Ts65Dn, a Down Syndrome Mouse Model

et al. 2011

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Individuals with Down syndrome (DS) present cognitive deficits that can be improved by early implementation of special care programs. However, they showed limited and temporary cognitive effects. We previously demonstrated that postnatal environmental enrichment (EE) improved clearly, though temporarily, the execution of visuospatial memory tasks in Ts65Dn mice, a DS model bearing a partial trisomy of murine chromosome 16; but in contrast to wild-type littermates, there was a lack of structural plasticity in pyramidal cell structure in the trisomic cerebral cortex. In the present study, we have investigated the impact of EE on the function of adenylyl cyclase and phospholipase C as a possible mechanism underlying the time-limited improvements observed. Basal production of cyclic adenosine monophosphate (cAMP) was not affected, but responses to GTPγS, isoprenaline, noradrenaline, SKF 38393 and forskolin were depressed in the Ts65Dn hippocampus. In EE conditions, cAMP accumulation was not significantly modified in control animals with respect to nonenriched controls. However, EE had a marked effect in Ts65Dn mice, in which cAMP production was significantly increased. Similarly, EE increased phospholipase C activity in Ts65Dn mice, in response to carbachol and calcium. We conclude that EE restores the G-protein-associated signal transduction systems that are altered in Ts65Dn mice.

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“…Likewise, blockade of NMDA receptors, glutamate receptors involved in perforant path-granule cell synapses, increases adult neurogenesis (Cameron et al, 1995; Maekawa et al, 2009). Moreover, manipulation of cholinergic inputs, via either neurotoxin or pharmacological intervention, alters the rate of adult neurogenesis (Kotani et al, 2006; Frechette et al, 2009). Although not directly explored in the context of adrenal steroids, these afferent populations contain adrenal steroid receptors and may be one of the intermediate steps between alterations in hormone levels and changes in the production of new neurons.…”

Section: Mechanisms Underlying Stress Effects On Adult Neurogenesismentioning

confidence: 99%

Stress, stress hormones, and adult neurogenesis

Schoenfeld

Gould

2012

Experimental Neurology

319

232

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The dentate gyrus of the hippocampus continues to produce new neurons throughout adulthood. Adult neurogenesis has been linked to hippocampal function, including learning and memory, anxiety regulation and feedback of the stress response. It is thus not surprising that stress, which affects hippocampal function, also alters the production and survival of new neurons. Glucocorticoids, along with other neurochemicals, have been implicated in stress-induced impairment of adult neurogenesis. Paradoxically, increases in corticosterone levels are sometimes associated with enhanced adult neurogenesis in the dentate gyrus. In these circumstances, the factors that buffer against the suppressive influence of elevated glucocorticoids remain unknown – their discovery may provide clues to reversing pathological processes arising from chronic exposure to aversive stress.

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Developmental forebrain cholinergic lesion and environmental enrichment: Behaviour, CA1 cytoarchitecture and neurogenesis

Cited by 32 publications

References 69 publications

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

Wheel Running and Environmental Complexity as a Therapeutic Intervention in an Animal Model of FASD

G-Protein-Associated Signal Transduction Processes Are Restored after Postweaning Environmental Enrichment in Ts65Dn, a Down Syndrome Mouse Model

Stress, stress hormones, and adult neurogenesis

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