Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring

Pawluski, Jodi L.; Rayen, Ine; Niessen, Neville Andrew; Kristensen, Stephanie; Donkelaar, Eva L. van; Balthazart, J.; Steinbusch, Harry W.M.; Charlier, Thierry

doi:10.1016/j.neuroscience.2012.06.034

Cited by 86 publications

(73 citation statements)

References 76 publications

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“…First, maternal behaviour was assessed only with one test (pup retrieval). While we and a number of other researchers [73,86,89,90] have not found differences in maternal behaviour between Flx-exposed and control dams, Pawluski et al [91] demonstrated an increase in arched-back nursing in rat dams exposed to Flx. Because maternal behaviour is known to affect offspring outcomes, a more thorough investigation following Flx administration is crucial.…”

Section: Discussioncontrasting

confidence: 70%

“…Maternal stress alone is known to be able to affect fetal development and the child's health as well as longer-term behavioural outcomes (for a review see [92] and [93]). Furthermore, studies that examine long-term outcomes of early Flx exposure have shown that perinatal stress and Flx exposure interact and significantly affect the animals as adolescents and adults [73,74,75,89,94]. While beyond the scope of this study, the long-term consequences of maternal stress and Flx exposure on the offspring, separately and in combination, should be examined.…”

Section: Discussionmentioning

confidence: 99%

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Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Kiryanova

Dyck

2014

Dev Neurosci

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Rationale: Fluoxetine (Flx; brand names Prozac, Sarafem, Rapiflux), a selective serotonin reuptake inhibitor, is prescribed for the treatment of depression in pregnant women; however, this commonly prescribed medication could affect fetal brain development as Flx crosses the placenta. The available data concerning the anatomical and behavioural consequences of perinatal exposure to Flx during early development on adult behaviour are limited and often contradictory. Objectives: To further delineate the long-term behavioural effects of altering 5-HT during development, we examined the effects of perinatal Flx exposure on the behaviour of male mice as adults. Methods: Dams were treated with approximately 25 mg/kg/day of Flx from embryonic day 15 to postnatal day 12, and the behaviour of the adult offspring was assessed. Results: We found that perinatal Flx exposure leads to increased aggression, improved spatial memory, and reduced anxiety-like behaviour. This exposure did not cause memory deficits, changes in sensory processing, or changes in gross motor function. Conclusions: Our results suggest that while perinatal exposure to Flx may have long-term effects on adult behaviour, these effects appear limited and not necessarily detrimental.

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Kiryanova

Dyck

2014

Dev Neurosci

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Section: Discussionmentioning

confidence: 99%

“…In particular, there are many models employed during development of the brain, early life, puberty or particular stages of reproduction (e.g. post-partum) that are of great importance in the investigation of sex differences in psychiatric disorders (Galea et al, 2008;Goel and Bale, 2009;Brummelte and Galea, 2010;Glover and Hill, 2012;Pawluski et al, 2012;McCormick and Green, 2013).One conclusion that could be drawn from exploring the field is that consensus on sex differences in behavioural pharmacology is more often the exception than the rule. A combination of relatively fewer research groups consistently studying sex differences and scattered studies that incidentally perform between-sex comparisons has not yet produced a clear understanding of the male and female behavioural phenotype in most rodent models.…”

mentioning

confidence: 99%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

350

187

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Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

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“…That said, there are a growing number of rodent studies that call into question the long-term safety of antidepressants and their potential for adversely affecting the developing brains of our patients [25,26,27,28,29]. …”

mentioning

confidence: 99%

The Risks and Benefits of Antidepressants to Treat Pediatric-Onset Depression and Anxiety Disorders: A Developmental Perspective

Leckman¹

2013

Psychother Psychosom

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Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring

Cited by 86 publications

References 76 publications

Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Increased Aggression, Improved Spatial Memory, and Reduced Anxiety-Like Behaviour in Adult Male Mice Exposed to Fluoxetine Early in Life

Sex differences in animal models of psychiatric disorders

The Risks and Benefits of Antidepressants to Treat Pediatric-Onset Depression and Anxiety Disorders: A Developmental Perspective

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