Developmental expression of transforming growth factor-? and epidermal growth factor receptor proteins in the human pancreas and digestive tract

Hormi, Khadija; Lehy, Thérèse

doi:10.1007/s004410050234

Cited by 4 publications

(6 citation statements)

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“…Transforming growth factor (TGF)-␣ is a member of the epidermal growth factor (EGF) family that is implicated in phenomena of duct cell proliferation that precede islet cell differentiation (Wang et al 1993). Its receptor (EGF-R) is broadly expressed in the pancreas, but mostly by islet cells (Hormy and Lehy 1994). TGF-␣ is detectable in ducts of normal rat pancreas (Wang et al 1997a) and is overexpressed by duct and acinar cells in chronic pancreatitis (Korc et al 1994).…”

Section: Pancreatic Ductal Influence On Islet Physiologymentioning

confidence: 99%

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Bertelli

Bendayan

2005

J Histochem Cytochem.

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S U M M A R YTraditional histological descriptions of the pancreas distinguish between the exocrine and the endocrine pancreas, as if they were two functionally distinct glands. This view has been proven incorrect and can be considered obsolete. Interactions between acinar and islet tissues have been well established through numerous studies that reveal the existence of anatomical and functional relationships between these compartments of the gland. Less attention, however, has traditionally been paid to the relationships occurring between the endocrine pancreas and the ductal system. Associations between islet tissue and ducts are considered by most researchers as only a transient epiphenomenon of endocrine development. This article reviews the evidence that has emerged in the last 10 years demonstrating the existence of stable, close, and systematic relationships between these two pancreatic compartments. Functional and pathophysiological implications are considered, and the existence of an "acinar-duct-islet" axis is put forward. The pancreas appears at present to be an integrated organ composed of three functionally related components of well-orchestrated endocrine and exocrine physiological responses.

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Section: Pancreatic Ductal Influence On Islet Physiologymentioning

confidence: 99%

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Bertelli

Bendayan

2005

J Histochem Cytochem.

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“…They normally also contain some derivatives of the pro-pancreatic polypeptide, especially peptide YY and others (19,20). Hormi & Lehy recognized an immunohistochemical staining for TGF-alpha in a few scattered (most probably neuroendocrine) mucosal cells of the colon (16). In our earlier study we could demonstrate the localization of TGF-alpha-like immunoreactivity in the neurosecretory granules of L-cells by immunohistochemical double staining and immunoelectron microscopy using the monoclonal antibody clone 213-4.4 (15).…”

Section: Discussionmentioning

confidence: 80%

“…It is produced as a precursor protein, which is membrane bound and is cleaved by enzymatic hydrolysis to act as a soluble growth factor molecule (14). Localization studies have provided evidence that TGF-alpha in the lower gut is expressed mainly in the superficial epithelial cells of the mucosa and in a subtype of enteroendocrine cells of the colorectum, which are called L-cells (15,16). Since normal L-cells regularly contain TGF-alpha-like immunoreactivity, which could be shown by immunohistochemistry and immunoelectron microscopy, we studied the ex- 932 pression of TGF-alpha in neuroendocrine tumours of the distal colon and rectum at the protein and m-RNA level.…”

mentioning

confidence: 99%

Expression of TGF‐alpha in neuroendocrine tumours of the distal colon and rectum

Back¹,

Rohr²,

Bleyl³

2003

APMIS

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“…Experimental studies have shown that EGF plays an important role in protecting the intestinal barrier function, and wound healing in necrotizing enterocolitis and ischemia-reperfusion injury models [5,6]. It has been shown that EGF has anti-inflammatory effects in human fetal intestinal and colonic cells [7]. It has been determined that a single nucleotide polymorphism located in the 5' untranslated region at position 61 of the EGF gene affects expression levels of EGF [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…This has been demonstrated to be an important marker for the reduction of tumor recurrence in patients with colorectal carcinoma [17]. Animal models and cell culture studies revealed the antiinflammatory role of EGF an EGFR in intestinal inflammation models [7,18].…”

Section: Introductionmentioning

confidence: 99%

Assessment of the role of EGF +61A/G and EGFR R497K polymorphism in patients with inflammatory bowel disease: A case-control study

Kahraman

İplik

Çalhan

et al. 2018

Archives of Clinical and Experimental Medicine

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Aim: Epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) play an important role in the regulation of cell growth, survival, migration, apoptosis, proliferation, and differentiation. We aimed to investigate the presence of EGF (+61A/G) and EGFR R497Kpolymorphisms in patients with inflammatory bowel disease (IBD) and their associations with clinical features of the patients. Methods: This case-control study included 91 IBD patients (45 Crohn's disease (CD) patients and 46 ulcerative colitis (UC) patients) and 129 healthy controls (HC).EGF and EGFR were genotyped by polymerase chain reaction and restriction fragment length polymorphism techniques to elucidate their association with clinical outcomes. The disease activity for UC and CD were assessed by Truelove-Witts index (TW) and Crohn's disease activity index (CDAI), respectively. The Montreal classification was used for disease involvement and behavior. Results: EGFR497 AA genotype was significantly decreased in patients with UC compared with CD and HC. In addition, the patients with UC who had EGF +61 A allele had increased risk of moderate and severe disease (p=0.28; OR= 3.13; 95% CI=0.34-28.73). The patients with CD who had the EGF61 AG genotype were found to increased risk for the presence of penetrating disease (p=0.14; χ2=5.59; OR=5.00; 95% CI=1.26-19.83). EGF +61 A genotype carriers also had higher CDAI scores (p=0.19; OR=4.00; 95% CI=0. 44-36.14). In addition, A+ carriers were also found to have higher requirement for anti-TNF treatment (p=0.11; OR=5.0; 95% CI=0.56-44.4). Conclusion: In this study, EGFR 497 AA genotype was found to decrease significantly in patients with UC compared to HC and CD patients. To enlighten the mechanism, further studies with larger sample groups are needed to clarify the role of the EGF (+61A/G) and EGFR R497K genes polymorphism, and development of the etiology and pathogenesis of IBD. Keywords: EGF61, EGFR497, inflammatory bowel diseases, Crohn's disease, ulcerative colitis Öz Amaç: Epidermal büyüme faktörü (EGF) ve epidermal büyüme faktörü reseptörü (EGFR), hücre büyümesi, canlılığı, migrasyonu, apoptoz, proliferasyon ve farklılaşmasının düzenlenmesinde önemli bir rol oynamaktadır. İnflamatuar barsak hastalığı (İBH) olan hastalarda EGF (+61A/G) ve EGFR R497K polimorfizmlerinin varlığını ve hastalığın klinik özellikler ile ilişkisini araştırmayı amaçladık. Yöntemler: Bu vaka kontrol çalışmasında 91 IBD hastası (45 Crohn hastalığı (CD) hastası ve 46 ülseratif kolit (UC) hastası) ve 129 sağlıklı kontrol (HC) vardı. EGF ve EGFR, polimeraz zincir reaksiyonu ve restriksiyon fragman uzunluğu polimorfizm teknikleri ile hastalık ve sağlıklı control grubu genotiplendirildi. Genotiplerinhastalık ve klinik özellikleri ile ilişkileri incelendi. UC ve CD için hastalık aktivitesi sırasıyla Truelove-Witts indeksi (TW) ve Crohn hastalığı aktivite indeksi (CDAI) ile değerlendirildi. Montreal sınıflandırması hastalık tutulumu ve davranışı için kullanılmıştır. Bulgular: Ulseratif kolit hastalarında EGFR497 AA genotipi CD v...

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Developmental expression of transforming growth factor-? and epidermal growth factor receptor proteins in the human pancreas and digestive tract

Cited by 4 publications

References 0 publications

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Association between Endocrine Pancreas and Ductal System. More than an Epiphenomenon of Endocrine Differentiation and Development?

Expression of TGF‐alpha in neuroendocrine tumours of the distal colon and rectum

Assessment of the role of EGF +61A/G and EGFR R497K polymorphism in patients with inflammatory bowel disease: A case-control study

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