2024
DOI: 10.1002/cpt.3409
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Developmental Expression of Drug Transporters and Conjugating Enzymes Involved in Enterohepatic Recycling: Implication for Pediatric Drug Dosing

Aarzoo Thakur,
Sandhya Subash,
Deepak Ahire
et al.

Abstract: Around 50% of the drugs used in children have never been tested for safety and efficacy in this vulnerable population. Immature drug elimination pathways can lead to drug toxicity when pediatric doses are determined using empirical methods such as body‐surface area or body‐weight‐normalized adult dosing. In the absence of clinical data, physiologically‐based pharmacokinetic (PBPK) modeling has emerged as a useful tool to predict drug pharmacokinetics in children. These models utilize developmental physiologica… Show more

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