Developmental exposure to decabromodiphenyl ether (PBDE 209): Effects on thyroid hormone and hepatic enzyme activity in male mouse offspring

Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae

“…While decreased T4 levels are generally observed in mammals and fish models exposed to PBDEs, the T3 levels were significantly increased in our study. Decreased levels of T3 concentration in mice have also been reported with BDE-209 treatment in rodent (Lee et al, 2010;Tseng et al, 2008).…”

“…Several reports have investigated thyroid endocrine disruption in rodents upon BDE-209 exposure (e.g., Rice et al, 2007;Tseng et al, 2008;Van der Ven et al, 2008;Lee et al, 2010). BDE-209 can be debrominated to lower congeners, which are more bioaccumulative and toxic by both biological and non-biological processes (Stapleton et al, 2004;USEPA, 2008).…”

PBDE flame retardants

“…Table 3 provides a summary of studies in fish conducted to date. Similar to results in fish, in vivo rodent studies and cell-based assays have reported PBDE-induced disruption of thyroid homeostasis, including declines in circulating THs [144][145][146] ; altered expression and activity of TH metabolizing enzymes, 147,148 and competitive binding with plasma transporters. 149 Human epidemiology studies have shown associations between altered plasma concentrations of THs in adults and PBDE levels in serum and dust.…”

Impact of Brominated POPs on the Neurodevelopment and Thyroid Hormones of Young Children in an Indoor Environment—A Review

“…PBDEs have been shown to cause reproductive disorders, have neurotoxic and developmental effects, and cause endocrine disruption and thyroid gland dysfunction in animal models (Costa and Giordano, 2007;Tseng et al, 2008;Tseng et al, 2011;Liu et al, 2012). Several epidemiological studies in the general population have strengthened the notion that PBDE exposure can induce adverse health effects (Mazdai et al, 2003;Chao et al, 2007;Main et al, 2007;Herbstman et al, 2008;Lim et al, 2008;Turyk et al, 2008;Turyk et al, 2009;Chao et al, 2010bChao et al, , 2011Gascon et al, 2012;Shy et al, 2012).…”