Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice

Ricceri, Laura; Markina, Nadja; Valanzano, Angela; Fortuna, Stefano; Cometa, Maria Francesca; Meneguz, Annarita; Calamandrei, Gemma

doi:10.1016/s0041-008x(03)00229-1

Cited by 92 publications

(98 citation statements)

References 63 publications

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“…Surprisingly, however, hyperactivity was not seen if prenatal exposure was followed by PND 11-14 exposure to a higher dose (3 mg/kgday). In animals treated only postnatally, the 3 mg/kg-day dose caused hyperactivity, as reported also in the previous study (Ricceri et al, 2003). Male mice exposed prenatally or postnatally to the high dose of chlorpyrifos (6 and 3 mg/kg-day chlorpyrifos, respectively) displayed increased agonistic behavior.…”

Section: Studies Of Abou-donia Et Alsupporting

confidence: 88%

“…On PND 15, both brain and serum AChE activities were unchanged by prenatal exposure to chlorpyrifos. Still, on PND 15, mice exposed prenatally to solvent and on PND 11-14 to chlorpyrifos (1 or 3 mg/kg-day) showed no changes in brain AChE activity (as in Ricceri et al, 2003), but a significant decrease (25 and 45%, respectively) of serum AChE. In animals that were exposed both prenatally and postnatally to chlorpyrifos, AChE activity was not affected in brain, but was decreased by 40 to 50% in serum.…”

Section: Studies Of Abou-donia Et Almentioning

confidence: 89%

“…In this study, chlorpyrifos was dissolved in corn oil and given by sc injection, and the absorption and bioavailability of chlorpyrifos upon such exposure are not known. Ricceri et al (2003) examined the effects of postnatal exposure to chlorpyrifos on PND 1-4 or PND 11-14 in mice. Chlorpyrifos was dissolved in DMSO and injected sc at the doses of 1 or 3 mg/kg-day.…”

Section: Studies Of Abou-donia Et Almentioning

confidence: 99%

“…Utilizing the same exposure protocol as Ricceri et al (2003), Venerosi et al (2006) investigated effects of developmental exposure to chlorpyrifos on a social recognition test in female mice on PND 120. Small but statistically significant effects were found in mice that were exposed to 6 mg/kg-day in utero (GD 15-18), followed by a 3-mg/kg-day exposure on PND 11-14, but not in any other group.…”

Section: Studies Of Abou-donia Et Almentioning

confidence: 99%

See 3 more Smart Citations

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Eaton¹,

Daroff²,

Autrup³

et al. 2008

Critical Reviews in Toxicology

558

413

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Section: Studies Of Abou-donia Et Alsupporting

confidence: 88%

Section: Studies Of Abou-donia Et Almentioning

confidence: 89%

Section: Studies Of Abou-donia Et Almentioning

confidence: 99%

Section: Studies Of Abou-donia Et Almentioning

confidence: 99%

See 2 more Smart Citations

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Eaton¹,

Daroff²,

Autrup³

et al. 2008

Critical Reviews in Toxicology

558

413

View full text Add to dashboard Cite

“…[11][12][13]25 Nonetheless, low-dose exposure to OPs can affect a tremendous variety of developmentally relevant targets, ranging from acetylcholinesterase, to DNA synthesis and serotoninergic neurotransmission. [53][54][55][56] These toxins could thus affect brain growth and maturation in genetically vulnerable individuals through several different mechanisms, in addition to the Reelin pathway.…”

Section: Markersmentioning

confidence: 99%

Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions

et al. 2005

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Organophosphates (OPs) are routinely used as pesticides in agriculture and as insecticides within the household. Our prior work on Reelin and APOE delineated a gene-environment interactive model of autism pathogenesis, whereby genetically vulnerable individuals prenatally exposed to OPs during critical periods in neurodevelopment could undergo altered neuronal migration, resulting in an autistic syndrome. Since household use of OPs is far greater in the USA than in Italy, this model was predicted to hold validity in North America, but not in Europe. Here, we indirectly test this hypothesis by assessing linkage/association between autism and variants of the paraoxonase gene (PON1) encoding paraoxonase, the enzyme responsible for OP detoxification. Three functional single nucleotide polymorphisms, PON1 CÀ108T, L55M, and Q192R, were assessed in 177 Italian and 107 Caucasian-American complete trios with primary autistic probands. As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: v 2 ¼ 6.33, 1 df, Po0.025), transmission/disequilibrium tests (Q192R: TDT v 2 ¼ 5.26, 1 df, Po0.025), familybased association tests (Q192R and L55M: FBAT Z ¼ 2.291 and 2.435 respectively, Po0.025), and haplotype-based association tests (L55/R192: HBAT Z ¼ 2.430, Po0.025). These results are consistent with our model and provide further support for the hypothesis that concurrent genetic vulnerability and environmental OP exposure may possibly contribute to autism pathogenesis in a sizable subgroup of North American individuals.

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Scoring of Social Interactions and Play in Mice During Adolescence

Terranova

Laviola

2005

CP Toxicology

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This unit provides a description of methods that have proven useful in characterizing amicable and playful interactions of developing mice. Such a procedure can be used to evaluate the effects of perinatal and/or ongoing treatments on the social performance of periadolescent subjects of either or both sexes. It can also be complemented by the use of specific acute drug challenges, which can throw light on possible alterations of the subserving neurochemical systems. Basically, it consists of video recording brief sessions of spontaneous pair interactions and their subsequent observation and scoring according to a detailed mouse ethogram. The protocol is quite sensitive to subtle behavioral effects, which could be undetectable by other means, and it is most useful when repeated over several days to draw an ontogenetic profile. Critical parameters that must be considered when planning, e.g., sample size and timing of observations, are discussed in detail, along with the key issue of controlling for litter effects.

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Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice

Cited by 92 publications

References 63 publications

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment

Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene–environment interactions

Scoring of Social Interactions and Play in Mice During Adolescence

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