Developmental evidence for serial homology of the vertebrate jaw and gill arch skeleton

Gillis, J. Andrew; Modrell, Melinda S.; Baker, Clare V. H.

doi:10.1038/ncomms2429

Cited by 64 publications

(77 citation statements)

References 43 publications

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“…The three cranial neural crest streams of elasmobranchs (sharks, skates, and rays) have been studied by SEM in the cat shark, Scyliorhinus torazame , and the branchial stream has been shown to enter the gill arches (Kuratani and Horigome, ). In the skate Leucoraja erinacea , DiI labeling of neural crest‐derived pharyngeal arch mesenchyme of the first gill arch showed that these cells gave rise to chondrocytes of the gill arch endoskeleton (Gillis et al, ). Other derivatives were not the focus of this study, so it is unknown if neural crest cells gave rise to smooth muscle of the gill arch arteries.…”

Section: Origins Of the Cardiac Neural Crest: The Third Cranial Neuramentioning

confidence: 99%

Evolutionary and developmental origins of the cardiac neural crest: Building a divided outflow tract

Keyte

Alonzo-Johnsen

Hutson

2014

Birth Defects Research Pt C

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The cardiac neural crest cells (CNCCs) have played an important role in the evolution and development of the vertebrate cardiovascular system: from reinforcement of the developing aortic arch arteries early in vertebrate evolution, to later orchestration of aortic arch artery remodeling into the great arteries of the heart, and finally outflow tract septation in amniotes. A critical element necessary for the evolutionary advent of outflow tract septation was the co-evolution of the cardiac neural crest cells with the second heart field. This review highlights the major transitions in vertebrate circulatory evolution, explores the evolutionary developmental origins of the CNCCs from the third stream cranial neural crest, and explores candidate signaling pathways in CNCC and outflow tract evolution drawn from our knowledge of DiGeorge Syndrome.

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Section: Origins Of the Cardiac Neural Crest: The Third Cranial Neuramentioning

confidence: 99%

Evolutionary and developmental origins of the cardiac neural crest: Building a divided outflow tract

Keyte

Alonzo-Johnsen

Hutson

2014

Birth Defects Research Pt C

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“…Six Dlx genes have been identified in the leopard shark Triakis semifasciata , which have a usual bony fish genomic organization (at least two pairs, Dlx1 – 2 , Dlx5 – 6 , intergenic regions of 7–10 kb, and conserved intron-exon boundaries) [30]. We have isolated and identified 6 Dlx coding sequences in the small-spotted catshark Scyliorhinus canicula and described their expression pattern during tooth development [50], and recent thorough comparative studies of branchial arches development used Dlx gene expression in chondrichthyan species [51], [52]. These two studies focused on the putative role of Dlx gene products (and others’) in regionalizing branchial arches in the wide scheme of a Dlx code.…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Conservation of Dlx Paralog Co-Expression in Jawed Vertebrates

et al. 2013

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BackgroundThe Dlx gene family encodes transcription factors involved in the development of a wide variety of morphological innovations that first evolved at the origins of vertebrates or of the jawed vertebrates. This gene family expanded with the two rounds of genome duplications that occurred before jawed vertebrates diversified. It includes at least three bigene pairs sharing conserved regulatory sequences in tetrapods and teleost fish, but has been only partially characterized in chondrichthyans, the third major group of jawed vertebrates. Here we take advantage of developmental and molecular tools applied to the shark Scyliorhinus canicula to fill in the gap and provide an overview of the evolution of the Dlx family in the jawed vertebrates. These results are analyzed in the theoretical framework of the DDC (Duplication-Degeneration-Complementation) model.ResultsThe genomic organisation of the catshark Dlx genes is similar to that previously described for tetrapods. Conserved non-coding elements identified in bony fish were also identified in catshark Dlx clusters and showed regulatory activity in transgenic zebrafish. Gene expression patterns in the catshark showed that there are some expression sites with high conservation of the expressed paralog(s) and other expression sites with events of paralog sub-functionalization during jawed vertebrate diversification, resulting in a wide variety of evolutionary scenarios within this gene family.Conclusion Dlx gene expression patterns in the catshark show that there has been little neo-functionalization in Dlx genes over gnathostome evolution. In most cases, one tandem duplication and two rounds of vertebrate genome duplication have led to at least six Dlx coding sequences with redundant expression patterns followed by some instances of paralog sub-functionalization. Regulatory constraints such as shared enhancers, and functional constraints including gene pleiotropy, may have contributed to the evolutionary inertia leading to high redundancy between gene expression patterns.

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“…The configuration of the branchial bars and associated gills in Metaspriggina has three wider implications. The first is that this arrangement recalls their frequently invoked ancestral configuration [17][18][19] , even though this is usually regarded as hypothetical 19 . Primitive serial homology is often used as a starting point in discussions on the origin of jaws, although Metaspriggina is too basal (Fig.…”

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confidence: 99%