2020
DOI: 10.1002/cne.25029
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Developmental distribution of primary cilia in the retinofugal visual pathway

Abstract: The mammalian visual system is composed of circuitry connecting sensory input from the retina to the processing core of the visual cortex. The two main retinorecipient brain targets, the superior colliculus (SC) and dorsal lateral geniculate nucleus (dLGN), bridge retinal input and visual output. The primary cilium is a conserved organelle increasingly viewed as a critical sensor for the regulation of developmental and homeostatic pathways in most mammalian cell types. Moreover, cilia have been described as cr… Show more

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Cited by 12 publications
(13 citation statements)
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“…Unlike the dLGN, which matures later (Sewards and Sewards, 2002 ), the SC is not dependent on postnatal input from cortical areas as it can accomplish visual sensory functions in decorticated mice (Shanks et al, 2016 ). Furthermore, it plays a fundamental role in supporting the neuronal differentiation induced in other structures by retinal input (Alvarado et al, 2021 ). Through interactions between cell surface molecules and their ligands, the SC develops a series of topographically organized connections (Scicolone et al, 2009 ; Mendonça et al, 2010 ; Triplett and Feldheim, 2012 ; Carr et al, 2013 ; Chagas et al, 2019 ).…”
Section: The Brainstem and The Scmentioning
confidence: 99%
“…Unlike the dLGN, which matures later (Sewards and Sewards, 2002 ), the SC is not dependent on postnatal input from cortical areas as it can accomplish visual sensory functions in decorticated mice (Shanks et al, 2016 ). Furthermore, it plays a fundamental role in supporting the neuronal differentiation induced in other structures by retinal input (Alvarado et al, 2021 ). Through interactions between cell surface molecules and their ligands, the SC develops a series of topographically organized connections (Scicolone et al, 2009 ; Mendonça et al, 2010 ; Triplett and Feldheim, 2012 ; Carr et al, 2013 ; Chagas et al, 2019 ).…”
Section: The Brainstem and The Scmentioning
confidence: 99%
“…1,[3][4][5][6] Essential to central nervous system development, primary cilia are required for tissue patterning, neuronal migration, learning, and memory formation. [7][8][9][10] Defects of cilia in humans can result in a group of conditions called ciliopathies, that present in the brain, kidneys, and eyes. [11][12][13][14][15] During eye development, cilia exhibit dynamic behavior during early retinal differentiation and play roles in proliferation and survival of retinal progenitors.…”
mentioning
confidence: 99%
“…The ECM is connected to ion activity and to the asymmetric movement of primary cilia, that drives asymmetries in mice and other vertebrate species 23 . Moreover, cilia are present in the retina at the level of photoreceptors and in other retinal cell types 28 , 29 , acting in the detection and transduction of visual signals, macromolecules and other signals 108 . At the molecular level, we found enrichment of ion activity, including Ca 2+ ion binding, that is connected to the activity of cilia.…”
Section: Discussionmentioning
confidence: 99%
“…Cilia are dynamic, hair-like cell organelles that extend from the cell surface into the extracellular space 13 , 14 , 24 , 25 . They play an important role in detecting changes in the extracellular environment and transmitting signals to the cell that regulate developmental and physiological processes, including sensory function, cell adhesion and establishing the left–right body axis 24 , 26 29 . Due to molecular chirality, motor cilia induce a leftward flow of extracellular fluid detected by primary (or sensory) cilia 30 .…”
Section: Introductionmentioning
confidence: 99%