Developmental differences in the intestinal microbiota of Chinese 1-year-old infants and 4-year-old children

Guo, Min; Miao, Maohua; Wang, Yuezhu; Duan, Mengmeng; Yang, Fang; Chen, Yao; Wei, Yuan; Zheng, Huajun

doi:10.1038/s41598-020-76591-4

Cited by 17 publications

(17 citation statements)

References 54 publications

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“…However, the composition of the microbiome changes continuously with age. Comparison of the microbiome composition in infants and in 4-year-old children revealed the reduction in the population of phyla Proteobacteria and Actinobacteria accompanied by the increase in phyla Firmicutes and Bacteroidetes in the gut of the older children (Guo et al 2020).…”

Section: Alteration In Gut Microbiota With Agingmentioning

confidence: 97%

“…In general, as the microbiome functionality differs between infants and adults, therefore the microbial profiles are adapted in response, e.g., while the microbiota involved in amino acid and vitamin metabolism dominates in infants gut, these microbes will be slowly replaced by microbiota participated in fat metabolism with age (Guo et al 2020).…”

Section: Alteration In Gut Microbiota With Agingmentioning

confidence: 99%

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Microbiota’s role in health and diseases

El-Sayed

Aleya

Kamel

2021

Environ Sci Pollut Res

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The microbiome is a term that usually refers to the community of various microorganisms that inhabit/live inside human/animal bodies or on their skin. It forms a complex ecosystem that includes trillions of commensals, symbiotics, and even pathogenic microorganisms. The external environment, diet, and lifestyle are the major determinants influencing the microbiome's composition and vitality. Recent studies have indicated the tremendous influence of the microbiome on health and disease. Their number, constitution, variation, and viability are dynamic. All these elements are responsible for the induction, development, and treatment of many health disorders. Serious diseases such as cancer, metabolic disorders, cardiovascular diseases, and even psychological disorders such as schizophrenia are influenced directly or indirectly by microbiota. In addition, in the last few weeks, accumulating data about the link between COVID-19 and the microbiota were published. In the present work, the role of the microbiome in health and disease is discussed. A deep understanding of the exact role of microbiota in disease induction enables the prevention of diseases and the development of new therapeutic concepts for most diseases through the correction of diet and lifestyle. The present review brings together evidence from the most recent works and discusses suggested nutraceutical approaches for the management of COVID-19 pandemic.

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Section: Alteration In Gut Microbiota With Agingmentioning

confidence: 97%

Section: Alteration In Gut Microbiota With Agingmentioning

confidence: 99%

Microbiota’s role in health and diseases

El-Sayed

Aleya

Kamel

2021

Environ Sci Pollut Res

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“…Researchers have reported that healthy adults have significantly higher diversity of their gut microbiomes than young children in the United States (Ringel-Kulka et al, 2013). Similarly, a detailed comparison of the intestinal microbiota of 1-year-old infants and 4-year-old children in China revealed that the species richness, evenness, and diversity of the intestinal microbiota were significantly lower in the 1-year-olds (Guo et al, 2020). These aging effects not only occur in gut microbiota but also in other parts of the symbiotic microbiota.…”

Section: Community Structures Of Gut Microbiota Differed Between Juve...mentioning

confidence: 99%

Comparative Analysis of Intestinal Microflora Between Two Developmental Stages of Rimicaris kairei, a Hydrothermal Shrimp From the Central Indian Ridge

Lian

Zhu

et al. 2022

Front. Microbiol.

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Despite extreme physical and chemical characteristics, deep-sea hydrothermal vents provide a place for fauna survival and reproduction. The symbiotic relationship of chemotrophic microorganisms has been investigated in the gill of Rimicaris exoculata, which are endemic to the hydrothermal vents of the Mid-Atlantic Ridge. However, only a few studies have examined intestinal symbiosis. Here, we studied the intestinal fauna in juvenile and adult Rimicaris kairei, another species in the Rimicaris genus that was originally discovered at the Kairei and Edmond hydrothermal vent fields in the Central Indian Ridge. The results showed that there were significant differences between juvenile and adult gut microbiota in terms of species richness, diversity, and evenness. The values of Chao1, observed species, and ASV rarefaction curves indicated almost four times the number of species in adults compared to juveniles. In juveniles, the most abundant phylum was Deferribacterota, at 80%, while in adults, Campilobacterota was the most abundant, at 49%. Beta diversity showed that the intestinal communities of juveniles and adults were clearly classified into two clusters based on the evaluations of Bray–Curtis and weighted UniFrac distance matrices. Deferribacteraceae and Sulfurovum were the main featured bacteria contributing to the difference. Moreover, functional prediction for all of the intestinal microbiota showed that the pathways related to ansamycin synthesis, branched-chain amino acid biosynthesis, lipid metabolism, and cell motility appeared highly abundant in juveniles. However, for adults, the most abundant pathways were those of sulfur transfer, carbohydrate, and biotin metabolism. Taken together, these results indicated large differences in intestinal microbial composition and potential functions between juvenile and adult vent shrimp (R. kairei), which may be related to their physiological needs at different stages of development.

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“…and more complex composition compared to adults, suggesting ongoing microbial development [30]. On the contrary, a 2019 study reported a cohort of 281 school-aged children between six and nine years old to have an adult-like alpha diversity and a similar functional repertoire to that of adults [33], whilst a 2020 study reported four-year olds to have an adult-like gut microbiota, with significantly increased levels of adult gut-dominating phyla Bacteroidetes and Firmicutes and decreased infant-gut phyla Actinobacteria and Proteobacteria [34].…”

Section: The Development Of the Infant Gut Microbiotamentioning

confidence: 99%

The contrasting human gut microbiota in early and late life and implications for host health and disease

Skillington

Mills

Gupta³

et al. 2021

NHA

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The gut microbiota plays a significant role in health and development from birth and continues to affect several processes throughout life and into old age. During both infancy and old age, the trajectory of the gut microbiota changes with contrasting consequences at both stages for the host. The infant gut is unstable, and colonization is influenced by a variety of perinatal and postnatal factors. Many of these factors can contribute to an altered microbiota profile in infancy which can be associated with negative consequences later in life such as allergies, obesity, and neuropsychiatric disorders. The late-life gut microbiota is influenced by physiological changes within the host, illness, diet and lifestyle that impact its composition and functionality. Indeed, reduced microbial diversity, loss of beneficial microorganisms and increased pathobionts are key signatures of the elderly microbiome. Such changes have been associated with degenerative diseases including inflammageing, Alzheimer’s disease, Parkinson’s disease, and increased risk of infection with Clostridioides difficile. Here, we examine early- and late-life factors that contribute to contrasting gut microbiota disturbances and the consequences associated with these disruptions. Finally, we provide compelling evidence of nutritional and probiotic/prebiotic interventions that may help alleviate the effects of gut microbiota changes into old age.

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Developmental differences in the intestinal microbiota of Chinese 1-year-old infants and 4-year-old children

Cited by 17 publications

References 54 publications

Microbiota’s role in health and diseases

Microbiota’s role in health and diseases

Comparative Analysis of Intestinal Microflora Between Two Developmental Stages of Rimicaris kairei, a Hydrothermal Shrimp From the Central Indian Ridge

The contrasting human gut microbiota in early and late life and implications for host health and disease

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