Developmental delay in communication among toddlers and its relationship to caregiving behavior among violence-exposed, posttraumatically stressed mothers

Torrisi, Raffaella; Arnautovic, E; Perizzolo, Virginie C.; Vital, Marylène; Manini, Aurélia; Suardi, Francesca; Gex‐Fabry, Marianne; Serpa, Sandra Rusconi; Schechter, Daniel S.

doi:10.1016/j.ridd.2018.04.008

Cited by 9 publications

(11 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Less well understood is how the trauma effects change during development. The effects of maltreatment can be seen in childhood but identifying these subtle effects can be challenging until early adolescence when psychiatric disorders, as well as fear pathologies, increasingly emerge, with the amygdala and PFC targeted (Demers et al, 2018; Roos et al, 2018; Torrisi et al, 2018). The protracted development of the brain likely contributes to these developmental transitions (Giedd et al, 1999; Lupien et al, 2009; Raineki et al, 2010a,b; Rincon-Cortes et al, 2015; Teicher et al, 2016; Opendak et al, 2017; Hagler et al, 2018; Heany et al, 2018; Hodel, 2018; Lange et al, 2018; VanTieghem and Tottenham, 2018; Botros et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation

Opendak

LeDoux

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Early life maltreatment by the caregiver constitutes a major risk factor for the development of later-life psychopathologies, including fear-related pathologies. Here, we used an animal model of early life maltreatment induced by the Scarcity-Adversity Model of low bedding (LB) where the mother is given insufficient bedding for nest building while rat pups were postnatal days (PN) 8-12. To assess effects of maltreatment on the expression of threat-elicited defensive behaviors, animals underwent odor-shock threat conditioning at three developmental stages: late infancy (PN18), adolescence (PN45) or adulthood (>PN75) and tested the next day with odor only presentations (cue test). Results showed that in typically developing rats, the response to threat increases with maturation, although experience with maltreatment in early infancy produced enhanced responding to threat in infancy and adulthood, but a decrease in maltreated adolescents. To better understand the unique features of this decreased threat responding in adolescence, c-Fos expression was assessed within the amygdala and ventromedial prefrontal cortex (vmPFC) associated with the cued expression of threat learning. Fos counts across amygdala subregions were lower in LB rats compared to controls, while enhanced c-Fos expression was observed in the vmPFC prelimbic cortex (PL). Correlational analysis between freezing behavior and Fos revealed freezing levels were correlated with CeA in controls, although more global correlations were detected in LB-reared rats, including the BA, LA, and CeA. Functional connectivity analysis between brain regions showed that LB reared rats exhibited more diffuse interconnectivity across amygdala subnuclei, compared the more heterogeneous patterns observed in controls. In addition, functional connectivity between the IL and LA switched from positive to negative in abused adolescents. Overall, these results suggest that in adolescence, the unique developmental decrease in fear expression following trauma is associated with distinct changes in regional function and long-range connectivity, reminiscent of pathological brain function. These results suggest that early life maltreatment from the caregiver perturbs the developmental trajectory of threatelicited behavior. Indeed, it is possible that this form of trauma, where the infant's safety signal or "safe haven" (the caregiver) is actually the source of the threat, produces distinct outcomes across development.

show abstract

Section: Introductionmentioning

confidence: 99%

Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation

Opendak

LeDoux

et al. 2019

Front. Behav. Neurosci.

View full text Add to dashboard Cite

show abstract

“…131 Overall, less optimal internal working models and severity of maternal mood or PTSD symptoms and alexithymia were associa ted with more negative parenting behaviors, lower reflective function, and negative offspring outcomes. 105,110,112,113,119,122,[126][127][128] Further, in families impacted by intimate partner violence, children had more insecure and less stable attachment styles and male offspring were more likely to exhibit aggressive touch. 120,121,123,125 By contrast, more secure maternal adult attachment style was associated with better child outcomes across multiple studies.…”

Section: Childhood Maltreatment Experiences and Impaired Internal Wor...mentioning

confidence: 99%

“…Relationships with offspring and offspring outcomes. Of the 54 articles pertinent to associations between impaired internal working models and early parent-child relationships and offspring outcomes, 14,59,62,63,71,72,76,77,92,[107][108][109][110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][126][127][128][129][130]134,139,147,156,[165][166][167][168][169][170][171][172][173][174][175][176][177]…”

Section: Perinatal Substance Use and Impaired Internal Working Modelsmentioning

confidence: 99%

Maternal Childhood Maltreatment, Internal Working Models, and Perinatal Substance Use: Is There a Role for Hyperkatifeia? A Systematic Review

et al. 2023

View full text Add to dashboard Cite

The parent-infant relationship is critical for socioemotional development and is adversely impacted by perinatal substance use. This systematic review posits that the mechanisms underlying these risks to mother-infant relationships center on 3 primary processes: (1) mothers’ childhood maltreatment experiences; (2) attachment styles and consequent internal working models of interpersonal relationships; and (3) perinatal substance use. Further, the review considers the role of hyperkatifeia, or hypersensitivity to negative affect which occurs when people with substance use disorders are not using substances, and which drives the negative reinforcement in addiction. The authors performed a systematic review of articles (published 2000-2022) related to these constructs and their impact on mother-infant relationships and offspring outcomes, including original clinical research articles addressing relationships between these constructs, and excluding case studies, reviews, non-human animal studies, intervention studies, studies with fewer than 30% female-sex participants, clinical guidelines, studies limited to obstetric outcomes, mechanistic/biological studies, and studies with methodological issues precluding interpretation. Overall 1844 articles were screened, 377 were selected for full text review, and data were extracted from 157 articles. Results revealed strong relationships between mothers’ childhood maltreatment experiences, less optimal internal working models, and increased risk for perinatal substance use, and importantly, all of these predictors interacted with hyperkatifeia and exerted a marked impact on mother-infant relationships with less data available on offspring outcomes. These data strongly support the need for future studies addressing the additive impact of maternal childhood maltreatment experiences, suboptimal internal working models, and perinatal substance use, with hyperkatifeia as a potential moderator, and their interacting effects on mother-infant socioemotional outcomes.

show abstract

“…Studies routinely find that positive parenting is associated with better child language outcomes across the earliest years of child development. 17,18 Other research has demonstrated that children whose parents have experienced interpersonal traumas exhibit less language competence when parent-child interactions are strained, 19 suggesting that parenting behavior may be a link between parental experiences of adversity and subsequent child language competence.…”

Section: Adversity Parenting and Child Language Developmentmentioning

confidence: 99%

Infant Mental Health Home Visiting Mitigates Impact of Maternal Adverse Childhood Experiences on Toddler Language Competence: A Randomized Controlled Trial

Riggs¹,

Rosenblum²,

Muzik³

et al. 2021

J Dev Behav Pediatr

View full text Add to dashboard Cite

:Objective:The goal of this study was to test the impact of maternal adverse childhood experiences (ACEs) on subsequent child language competence; higher parental ACEs were expected to predict risk of toddler language delay. Participation in Infant Mental Health Home Visiting (IMH-HV) treatment, which aims to enhance responsive caregiving and improve child social-emotional development, was expected to mitigate this association.Methods:A randomized controlled trial (RCT) design was used. ACEs data were collected at baseline. Child language screening (using the Preschool Language Scales Screening Test) was conducted 12 months later by masters-level evaluators who were blind to treatment condition. Visits occurred in participants' homes. Participants were community-recruited and were randomized to treatment (psychotherapeutic IMH-HV) or control (treatment as usual). Data come from 62 families who participated in all waves of an RCT testing the efficacy of IMH-HV; mothers were eligible based on child age (<24 mo at enrollment) and endorsement of ≥2 sociodemographic eligibility criteria (economic disadvantage, depression, perceived parenting challenges, and/or high ACEs).Results:The age of mothers enrolled in this ranged from 19 to 44 years (M = 31.91; SD = 5.68); child age at baseline ranged from prenatal to 26 months (M = 12.06; SD = 6.62). The maternal ACE score predicted child language competence (t (5,55) = −3.27, p = 0.002). This effect was moderated by treatment (t (6,54) = 1.73, p = 0.04), indicating no association between maternal ACEs and child language for those randomized to IMH-HV.Conclusion:The results highlight that the effects of parent ACEs on early childhood outcomes may be buffered by participation in psychotherapeutic home visiting (trial registration: NCT03175796).

show abstract

Developmental delay in communication among toddlers and its relationship to caregiving behavior among violence-exposed, posttraumatically stressed mothers

Cited by 9 publications

References 83 publications

Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation

Development of Threat Expression Following Infant Maltreatment: Infant and Adult Enhancement but Adolescent Attenuation

Maternal Childhood Maltreatment, Internal Working Models, and Perinatal Substance Use: Is There a Role for Hyperkatifeia? A Systematic Review

Infant Mental Health Home Visiting Mitigates Impact of Maternal Adverse Childhood Experiences on Toddler Language Competence: A Randomized Controlled Trial

Contact Info

Product

Resources

About