Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish

Park, Junho; An, Garam; Park, Hahyun; Hong, Taeyeon; Lim, Whasun; Song, Gwonhwa

doi:10.1016/j.envint.2023.107973

Cited by 12 publications

(2 citation statements)

References 85 publications

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“…L-FABP may control the availability of long-chain fatty acids (LCFAs) and their oxidative metabolites with ligands. Resulting in limiting the free LCFA fraction, modulating the interaction of LCFAs with nuclear receptors, and trapping or scavenging reactive species such as ROS and RNS are known to be effective antioxidant agents participating in S-thiolation/de-thiolation reactions, and several methionine groups [ 32 , 33 ]. Methionine residues are considered cellular scavengers of activated xenobiotics such as carcinogens [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative quantitation of liver-type fatty acid-binding protein localizations in liver injury and non-pathological liver tissue in dogs

Arunorat,

Chusakulwong,

Sakunasing

et al. 2024

Vet World

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Background and Aim: Liver injury results in the production of free radicals that can lead to hepatocytic degeneration, cirrhosis, and hepatocellular carcinoma (HCC). Liver-fatty acid-binding protein (L-FABP) is highly expressed in hepatocytes and is a key regulator of hepatic lipid metabolism and antioxidant characteristics. Interestingly, the increase in L-FABP expression could be used as a novel marker of liver injury. Therefore, this study aimed to use immunohistochemical techniques to investigate the expression of L-FABP in dogs with liver injury compared with dogs with non-pathological liver. Materials and Methods: Liver tissue samples were collected from dog biopsy specimens at the Veterinary Diagnostic Laboratory at the Faculty of Veterinary Medicine, Chiang Mai University. The tissues were prepared for immunohistochemistry and the expression and localization of L-FABP were investigated using one-way analysis of variance. Results: Immunohistochemical analysis showed that L-FABP was strongly expressed in the hepatocytes of dogs with lipidosis and HCC when compared with that in normal liver. Semi-quantitative immunohistochemistry evaluation showed the percentage of protein expression of L-FABP 0.023 ± 0.027 in the non-pathological liver. The percentage of L-FABP protein expression in lipidosis and HCC was found to be 8.517 ± 1.059 and 17.371 ± 4.026, respectively. Conclusion: L-FABP expression in dogs with liver injuries was significantly higher than that in dogs with non-pathological liver injury (p = 0.05). These results suggest that L-FABP has the potential as a novel marker for specific diagnosis and prognosis of dogs with liver injury. Keywords: canine, hepatocyte, immunohistochemistry, lipidosis, liver injury, liver-fatty acid-binding protein, pathology.

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Section: Discussionmentioning

confidence: 99%

Comparative quantitation of liver-type fatty acid-binding protein localizations in liver injury and non-pathological liver tissue in dogs

Arunorat,

Chusakulwong,

Sakunasing

et al. 2024

Vet World

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“…[5][6] However, problems such as environmental contamination, compromised food safety, and damage to non-target organisms have arisen from the prolonged and careless use of chemically synthesized fungicides. [7][8][9] Therefore, low-toxicity fungicides derived from plants have emerged as suitable alternatives and are gaining significant attention from researchers. [10][11][12][13][14] Moutan cortex (MC), derived from the root bark of Paeonia suffruticosa Andrews, has been utilized in China's clinical practice for nearly 2000 years.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

Zhao,

Wang,

Han

et al. 2024

Chemistry & Biodiversity

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Rice sheath blight (RSB), caused by Rhizoctonia solani, is a significant disease of rice. The negative effects of chemical fungicides have created an urgent need for low‐toxicity botanical fungicides. Our previous research revealed that the ethanol crude extract of Moutan Cortex (MC) exhibited superior antifungal activity against R. solani at 1000 μg/mL, resulting in 100% inhibition rate. And the antifungal properties were mainly found in the petroleum ether extract. However, the active ingredients of the extract are still unclear. In this study, gas chromatography‐mass spectrometry (GC‐MS) was utilised for the analysis of its chemical components. The mycelium growth rate method was utilized to detect the antifungal activity. The findings indicated that paeonol constituted the primary active component, with a content of more than 96%. Meanwhile, paeonol was the most important antifungal active ingredient, the antifungal activity of paeonol (EC50 = 44.83 μg/mL) was much higher than that of β‐sitosterol and ethyl propionate against R. solani. Observation under an optical microscope revealed that paeonol resulted in abnormal mycelial morphology. This study provided theoretical support for identifying monomer antifungal compounds and developing biological fungicides for R. solani.

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Dimethenamid promotes oxidative stress and apoptosis leading to cardiovascular, hepatic, and pancreatic toxicities in zebrafish embryo

Park,

An,

You

et al. 2023

Comparative Biochemistry and Physiology Part C: Toxicology &

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Developmental defects induced by thiabendazole are mediated via apoptosis, oxidative stress and alteration in PI3K/Akt and MAPK pathways in zebrafish

Cited by 12 publications

References 85 publications

Comparative quantitation of liver-type fatty acid-binding protein localizations in liver injury and non-pathological liver tissue in dogs

Comparative quantitation of liver-type fatty acid-binding protein localizations in liver injury and non-pathological liver tissue in dogs

Inhibitory Activity Against Rhizoctonia Solani and Chemical Composition of Extract from Moutan Cortex

Dimethenamid promotes oxidative stress and apoptosis leading to cardiovascular, hepatic, and pancreatic toxicities in zebrafish embryo

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