Developmental correlation of diffusion anisotropy with auditory-evoked response

Roberts, Timothy P.L.; Khan, Sarah Y.; Blaskey, Lisa; Dell, John; Levy, Susan E.; Zarnow, Deborah M.; Edgar, J. Christopher

doi:10.1097/wnr.0b013e3283306854

Cited by 59 publications

(49 citation statements)

References 20 publications

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“…Taken together, present findings support a line of reasoning that considers M100 peak latency as a marker for autism spectrum disorders, perhaps secondary to abnormal white matter development of the acoustic radiations [14] or other local cortical circuitry abnormalities. Along this line of reasoning, Verhoeven et al [15] recently reported reduced fractional anisotropy in the superior longitudinal fasciculus of patients with specific language impairment but not those with autism spectrum disorder and language impairment when compared to healthy controls.…”

Section: Discussionsupporting

confidence: 83%

Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment

Roberts

Heiken²,

Kahn³

et al. 2012

NeuroReport

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Recent studies show that electrophysiological markers of auditory processing such as the cortical 100ms response (M100) and the mismatch field (MMF), derived from magnetoencephalography (MEG), might be used to identify children with autism spectrum disorders -M100 peak latencyand to stratify children with autism according to the degree of language impairment -mismatch field peak latency.The present study examined the latencies of right superior temporal gyrus M100 and mismatch field in a cohort of children and young adolescents with specific language impairment (n=17), in comparison to age and non-verbal IQ matched typically developing controls (n=21). Neither group showed symptoms associated with autism.Whereas M100 latency (reflecting early auditory processing) did not distinguish controls from children with specific language impairment, the later "change detection" mismatch field response was significantly delayed (by >50ms) in the specific language impairment group. Linear discriminant analysis confirmed the role of mismatch field latency (92%) but not M100 latency (8%) in distinguishing groups.Present results add support to the claim that a delayed M100 is specific to autism spectrum disorders (with relative independence of degree of language impairment) and that a delayed mismatch field reflects an abnormality more generally associated with language impairment, suggesting that mismatch field delay in the present specific language impairment group and previously reported in autistic children with language impairment may be indicative of a common neural system dysfunction.

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Section: Discussionsupporting

confidence: 83%

Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment

Roberts

Heiken²,

Kahn³

et al. 2012

NeuroReport

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“…Recent ERP studies have shown relationships between the magnitude of the brain’s electrophysiological response and white matter microstructure (Westlye et al, 2009; Colrain et al, 2011). Our data strengthen the view that the microstructure of white matter fiber tracts subserving the N400 generators may impact the nature of the N400 response, perhaps by facilitating efficient neuronal conduction (Peters, 2009; Roberts et al, 2009). P300 latencies have been found to be associated more with white matter connectivity than the gray matter volume (Cardenas et al, 2005), and our results indicate that similar relationships may hold for the strength of N400 response.…”

Section: Discussionsupporting

confidence: 82%

Age-Related Changes in the Neurophysiology of Language in Adults: Relationship to Regional Cortical Thinning and White Matter Microstructure

et al. 2012

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Although reading skill remains relatively stable with advancing age in humans, neurophysiological measures suggest potential reductions in efficiency of lexical information processing. It is unclear whether these age-related changes are secondary to decreases in regional cortical thickness and/or microstructure of fiber tracts essential to language. Magnetoencephalography, volumetric MRI, and diffusion tensor imaging were performed in 10 young (18–33 years) and 10 middle-aged (42–64 years) human individuals to evaluate the spatiotemporal dynamics and structural correlates of age-related changes in lexical-semantic processing. Increasing age was associated with reduced activity in left temporal lobe regions from 250–350ms and in left inferior prefrontal cortex from 350–450ms (i.e., N400). Hierarchical regression indicated that age no longer predicted left inferior prefrontal activity after cortical thickness and fractional anisotropy (FA) of the uncinate fasciculus (UF) were considered. Interestingly, FA of the UF was a stronger predictor of the N400 response than cortical thickness. Age-related reductions in left-lateralization of language responses were observed between 250–350ms, and were associated with left temporal thinning and frontotemporal FA reductions. N400 reductions were not associated with poorer task performance. Rather, increasing age was associated with reduction in the left prefrontal N400, which in turn was also associated with slower response time. These results reveal that changes in the neurophysiology of language occur by middle age and appear to be partially mediated by structural brain loss. These neurophysiological changes may reflect an adaptive process that ensues as communication between left perisylvian regions declines.

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“…In the present study, observation of a M50 response in all groups likely reflects development of cortical layers III and IV, with the delayed M50 latency in both ASD groups perhaps indicating slower maturation of these layers, perhaps due to delayed myelination of thalamo-cortical pathways in ASD (Roberts et al, 2009, 2013). Lack of a M100 in the young ASD − LI and ASD + LI groups may indicate delayed maturation of layer II and upper layer III in ASD with abnormally decreased synchronization of afferent activity arriving at the synapses in layer II and upper layer III resulting in a greatly desynchronized M100 (Ponton and Eggermont, 2001).…”

Section: Discussionmentioning

confidence: 49%

Missing and Delayed Auditory Responses in Young and Older Children with Autism Spectrum Disorders

Edgar

Lanza

Daina

et al. 2014

Front. Hum. Neurosci.

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Background: The development of left and right superior temporal gyrus (STG) 50 ms (M50) and 100 ms (M100) auditory responses in typically developing (TD) children and in children with autism spectrum disorder (ASD) was examined. Reflecting differential development of primary/secondary auditory areas and supporting previous studies, it was hypothesized that whereas left and right M50 STG responses would be observed equally often in younger and older children, left and right M100 STG responses would more often be absent in younger than older children. In ASD, delayed neurodevelopment would be indicated via the observation of a greater proportion of ASD than TD subjects showing missing M100 but not M50 responses in both age groups. Missing M100 responses would be observed primarily in children with ASD with language impairment (ASD + LI) (and perhaps concomitantly lower general cognitive abilities).Methods: Thirty-five TD controls, 63 ASD without language impairment (ASD − LI), and 38 ASD + LI were recruited. Binaural tones were presented. The presence or absence of a STG M50 and M100 was scored. Subjects were grouped into younger (6–10 years old) and older groups (11–15 years old).Results: Although M50 responses were observed equally often in older and younger subjects and equally often in TD and ASD, left and right M50 responses were delayed in ASD − LI and ASD + LI. Group comparisons showed that in younger subjects M100 responses were observed more often in TD than ASD + LI (90 versus 66%, p = 0.04), with no differences between TD and ASD − LI (90 versus 76%, p = 0.14) or between ASD − LI and ASD + LI (76 versus 66%, p = 0.53). In older subjects, whereas no differences were observed between TD and ASD + LI, responses were observed more often in ASD − LI than ASD + LI. Findings were similar when splitting the ASD group into lower- and higher-cognitive functioning groups.Conclusion: Although present in all groups, M50 responses were delayed in ASD. Examining the TD data, findings indicated that by 11 years, a right M100 should be observed in 100% of subjects and a left M100 in 80% of subjects. Thus, by 11 years, lack of a left and especially right M100 offers neurobiological insight into sensory processing that may underlie language or cognitive impairment.

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Developmental correlation of diffusion anisotropy with auditory-evoked response

Cited by 59 publications

References 20 publications

Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment

Delayed magnetic mismatch negativity field, but not auditory M100 response, in specific language impairment

Age-Related Changes in the Neurophysiology of Language in Adults: Relationship to Regional Cortical Thinning and White Matter Microstructure

Missing and Delayed Auditory Responses in Young and Older Children with Autism Spectrum Disorders

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