Developmental Coordination Disorder: Disruption of the Cerebello-Cerebral Network evidenced by SPECT

Abstract

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Brain Imaging Increases Our Understanding of Developmental Coordination Disorder: a Review of Literature and Future Directions

“…One case study using SPECT by Mariën et al in 2010 reported a disruption of the cerebello-cerebral network that is involved in executing planned actions, visuospatial cognition, and affective regulation [46]. These findings build on earlier behavioral studies [5•, 23] and suggest that the cerebellum is implicated in the pathophysiological mechanisms of DCD and corroborate Zwicker's fMRI results [22••].…”

“…Despite the small sample size, this is the first study to support the possible relationship between cerebellar under-recruitment and poor motor performance in children with DCD. Further, in a single case study, structural MRI confirmed the cerebellar involvement in a 19 year-old with DCD, indicating functional disruption of the cerebellum [46]. Future brain imaging studies using motor learning tasks will be crucial to further our understanding of the role of the cerebellum in DCD.…”

Intact procedural motor sequence learning in developmental coordination disorder

“…Clinically, DCD children have been observed to experience difficulties automatizing their gestures: for instance, in contrast with peers, movements to tie shoes continue to require particular attention, even after a great deal of practice. In support of this procedural learning deficit hypothesis, some studies have showed that dysfunction of cerebellum and basal ganglia might be involved in the pathogenesis of DCD (Brookes, Nicolson, & Fawcett, 2007;Cherng, Liang, Chen, & Chen, 2009;Marien, Wackenier, De Surgeloose, De Deyn, & Verhoeven, 2010;Piek & Dyck, 2004;Zwicker, Missiuna, Harris, & Boyd, 2011). For instance, Zwicker et al (2011) explored brain activity during motor procedural learning (trail-tracing task using a joystick) in 7 children with DCD and 7 matched controls.…”

Lateralization of Brain Functions: A Randomized Single-Blinded Observational Study

“…However, there has been numerous several other studies and attempts, for correlating the effect of cerebral lateralization and visual analytic skills, using other investigative tools, including: tachistoscopic recognition; facial recognition; visuospatial attention; written verbal commands; Japanese kanji; and reaction-time studies; and functional MRI (fMRI) (19)(20)(21)(22)(23)(24)(25). Other parallel studies also examined subject with some neurological pathologies, including dyslexia; developmental disorders; and autism (26)(27)(28). On the other hand, this observational analytic study was conducted among normal Iraqi subjects from both gender, they were undergraduate medical students with high visual IQ.…”