Developmental characteristics of histamine methyltransferase and phenylethanolamine-N-methyltransferase of rat brain

Kouvelas, Elias D.; Savakis, Ch. E.; Tzebelikos, E. Th.; Bonatsos, G.; Mitrossilis, S.

doi:10.1007/bf01927588

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…1 B). These results are in agreement with Kouvelas et al (1976), who reported a postnatal increase in rat brain HMT activity that peaked at day 10. These authors suggested that the decline in postnatal HA (such as shown in Fig.…”

Section: Discussionsupporting

confidence: 93%

“…Correlations of HA and t-MH levels support this, since on these days significant correlations were found in all fractions except P,. Absence of correlation in the P, fraction may be due to its low HMT activity (Kouvelas et al, 1976). Such findings support the suggestion that HA leaves the PI fraction prior to its methylation.…”

Section: Discussionsupporting

confidence: 83%

“…Unlike HA, neonatal brain t-MH is not associated with the heavy particles of the nuclear fraction, but is found predominantly in the supernatant (Fig. 3B), as is HMT (Kuhar et al, 1971;Kouvelas et al, 1976). These findings suggest that HA is methylated after leaving the PI fraction.…”

Section: Discussionmentioning

confidence: 86%

“…Slopes of the correlated curves are proportional to the efficiency of HA methylation; the slopes of day 4 and 10 curves suggest that HA methylation is most efficient in supernatant fractions. Not surprisingly, these slopes are proportional to the subcellular distribution of HMT (Kouvelas et al, 1976).…”

Section: Discussionmentioning

confidence: 90%

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Ontogeny and Subcellular Distribution of Rat Brain Tele‐Methylhistamine

Hough

Khandelwal

Green

1982

Journal of Neurochemistry

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The whole brain content and subcellular distribution of histamine and its metabolite, tele-methylhistamine, were studied during postnatal development of the rat. Brain methylhistamine levels were similar to or greater than histamine levels, indicating that histamine methylation is a major metabolic pathway in neonatal brain, as it is in adults. When calculated per brain, histamine, methylhistamine, and histamine methyltransferase were all maximal 10 days after birth. In neonates, brain histamine was found almost entirely in nuclear fractions, whereas methylhistamine was found almost exclusively in supernatant fractions. By day 20, however, a greater proportion of both amines was localized in subcellular fractions containing synaptosomes, a finding consistent with histamine's suggested transmitter role. The ontogenic pattern of brain methylhistamine questions the mast cell origin of neonatal histamine, but may be consistent with a role for histamine in brain development.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 90%

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Ontogeny and Subcellular Distribution of Rat Brain Tele‐Methylhistamine

Hough

Khandelwal

Green

1982

Journal of Neurochemistry

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“…It is unlikely that this moderate response may be due to a high activity of HA-N-methyltransferase (HMT), the enzyme that inactivates HA in brain since in two separate studies a constant brain HMT activity which is similar to the adult, was found in rats from the 7th postnatal day (Martres et al, 1975;Kouvelas et al, 1976). Another aspect, maturation of the brain histaminergic system, remains to be briefly discussed.…”

Section: Discussionmentioning

confidence: 93%

Prolactin release induced by histamine in maturing male and female rats

Alvarez

Fabra

1980

J. Neural Transmission

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It has been previously shown that histamine (HA) increases PRL release in adult rats. The purpose of the present work was to determine the ontogeny of the HA-induced PRL response in male and female rats. Animals from day 1 to day 40 after birth were injected, under ether anesthesia, into the lateral brain ventricles with 9.0 micrograms HA (free base) per rat. Fifteen minutes later a sample of blood was taken from the jugular vein and plasma PRL levels were determined by RIA. Results obtained indicate that HA is able to induce increased PRL release in developing rats. Sex differences were observed. In male rats, the earliest PRL response was observed at day 10 whereas female rats showed clearcut responses at day 1. During development, males showed a quite regular pattern of responses but in female rats there were highly irregular; positive responses did present a 5-day periodicity. In general terms, the magnitude of the PRL responses in developing rats was lower than observed in adult rats. However, in 20-day old male and female rats and 40-day old female rats, a marked increase of PRL took place after the HA injection.

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Regional changes in phenylethanolamine‐N‐Methyltransferase of rat brain during development

Borges

Rodriguez²,

Urbina³

1980

J of Neuroscience Research

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The changes of phenylethanolamine-N-methyltransferase (PNMT, EC 2.1.1.28), the enzyme that catalyzes the final step in the biosynthesis of adrenaline, were studied during the development of several regions of rat brain. PNMT is present in medulla oblongata-pons, hypothalamus, cerebellum, and midbrain five days before birth, and a progressive increase in the enzyme activity is observed during development. The adult levels are attained between 15 and 20 days, depending on the region. The increases in PNMT activity in the rostral regions are higher than in the caudal regions. PNMT attains adult levels earlier than tyrosine hydroxylase and dopamine-beta-hydroxylase. The apparatus for adrenaline synthesis seems to be mature at three weeks after birth in the medulla oblongata-pons, which contains the cell bodies of adrenaline-containing neurons. In the other regions the adult levels of enzyme activity are attained at 15 days after birth.

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Developmental characteristics of histamine methyltransferase and phenylethanolamine-N-methyltransferase of rat brain

Cited by 5 publications

References 15 publications

Ontogeny and Subcellular Distribution of Rat Brain Tele‐Methylhistamine

Ontogeny and Subcellular Distribution of Rat Brain Tele‐Methylhistamine

Prolactin release induced by histamine in maturing male and female rats

Regional changes in phenylethanolamine‐N‐Methyltransferase of rat brain during development

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