Developmental Changes of Immunity and Different Responses to Weaning Stress of Chinese Indigenous Piglets and Duroc Piglets during Suckling and Weaning Periods

Ding, Sujuan; Cheng, Yueming; Azad, Md. Abul Kalam; Zhu, Qian; Huang, P. M.; Kong, Xiangfeng

doi:10.3390/ijms232415781

Cited by 6 publications

(3 citation statements)

References 40 publications

(45 reference statements)

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“…Those results are consistent with our previous findings, which indicated a higher liver index of the XCB piglets than the DR piglets at 21 days of age [26]. Overall, these findings support the hypothesis that up-regulated IGF-1R expression is one of the reasons for the strong anti-stress capability of Chinese indigenous pigs during weaning.…”

Section: Discussionsupporting

confidence: 93%

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Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning

Dou,

Azad,

Cheng

et al. 2023

Animals

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The present study investigated the insulin-like growth factors (IGFs) and their receptors and binding proteins among three pig breeds during weaning. Sixty Duroc (DR), Taoyuan black (TYB), and Xiangcun black (XCB) piglets (20 piglets per breed) were selected at 21 and 24 (3 days of post-weaning) days of age to analyze organ indices, plasma concentrations of IGF and IGF-binding proteins (IGFBPs) using ELISA kits, and gene expression of IGF-system-related components in different tissues. The plasma IGFBP-3 concentration in TYB piglets was higher (p > 0.05) than in the XCB and DR piglets at 21 days of age. At 21 days of age, compared with the DR piglets, the IGF-1 expression was lower (p < 0.05) in the kidney, but it was higher (p < 0.05) in the spleen of XCB and TYB piglets. At 24 days of age, the IGF-1 expression was higher (p < 0.05) in the kidney of TYB piglets than in the XCB and DR piglets, while IGFBP-3 in the stomach and IGFBP-4 in the liver of XCB and TYB piglets were lower (p < 0.05) compared with the DR piglets. Weaning down-regulated (p < 0.05) IGF-1 expression in the jejunum, spleen, and liver of piglets, while it up-regulated (p < 0.05) IGFBP-3 expression in the stomach, IGFBP-4 in the liver, IGFBP-5 in the ileum, and IGFBP-6 in the jejunum of DR piglets. Spearman’s correlation analysis showed a negative correlation (p < 0.05) between plasma IGFBP-2 and IGFBP-5 concentration and the organ indices of piglets. Collectively, there were significant differences in the IGF system components among the three pig breeds. The IGF system components were altered during weaning, which might be involved in weaning stress to decrease the growth of piglets.

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Section: Discussionsupporting

confidence: 93%

“…Data are expressed as mean ± SEM (n = 10). * Data obtained from previous studies[22,26]. DR: Duroc piglet; TYB: Taoyuan black piglet; XCB: Xiangcun black piglet.…”

mentioning

confidence: 99%

Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning

Dou,

Azad,

Cheng

et al. 2023

Animals

Self Cite

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“…The Taoyuan pig is a unique local breed in China, primarily distributed in Taoyuan County, Hunan Province. Xiangcun pigs, a crossbreed of Taoyuan and Duroc pigs, inherit Duroc’s high reproductive performance and acquire Taoyuan pigs’ high-quality meat, roughage tolerance, and disease resistance ( Ding et al, 2022 ; Liu et al, 2022 ). However, the fungal composition and distribution of host pathogenicity-related genes carried in the intestine of Taoyuan and crossbred Xiangcun pigs remain unreported.…”

Section: Introductionmentioning

confidence: 99%

Combined effects of host genetics and diet on porcine intestinal fungi and their pathogenic genes

Wang,

Liu,

Luo

et al. 2023

Front. Microbiol.

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As research on gut microbes progresses, it becomes increasingly clear that a small family of microbiota--fungi, plays a crucial role in animal health. However, little is known about the fungal composition in the pig intestine, especially after a dietary fiber diet and hybrid genetics, and the changes in host pathogenicity-associated genes they carry. The purpose of this study is to investigate the effects of diet and genetics on the diversity and structure of porcine intestinal fungi and to describe, for the first time, the host pathogenicity-related genes carried by porcine intestinal fungi. Samples of colonic contents were collected for metagenomic analysis using a 3 × 2 parsing design, where three pig breeds (Taoyuan, Duroc, and crossbred Xiangcun) were fed high or low fiber diets (n = 10). In all samples, we identified a total of 281 identifiable fungal genera, with Ascomycota and Microsporidia being the most abundant fungi. Compared to Duroc pigs, Taoyuan and Xiangcun pigs had higher fungal richness. Interestingly, the fiber diet significantly reduced the abundance of the pathogenic fungus Mucor and significantly increased the abundance of the fiber digestion-associated fungus Neocallimastix. Pathogenic fungi exert their pathogenicity through the genes they carry that are associated with host pathogenicity. Therefore, we obtained 839 pathogenicity genes carried by the spectrum of fungi in the pig intestine by comparing the PHI-base database. Our results showed that fungi in the colon of Taoyuan pigs carried the highest abundance of different classes of host pathogenicity-related genes, and the lowest in Duroc pigs. Specifically, Taoyuan pigs carried high abundance of animal pathogenicity-related genes (CaTUP1, CPAR2_106400, CaCDC35, Tfp1, CaMNT2), and CaTUP1 was the key gene for Candida pathogenicity. The intestinal fungal composition of crossbred Xiangcun pigs and the abundance of host pathogenicity-associated genes they carried exhibited a mixture of characteristics of Taoyuan and Duroc pigs. In conclusion, our results provide the first comprehensive report on the effects of dietary fiber and genetics on the composition of intestinal fungi and the host-associated pathogenicity genes they carry in pigs. These findings provide a reference for subsequent pig breeding and development of anti-pathogenic fungal drugs.

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Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods

Ding,

Cheng,

Azad

et al. 2024

Animal Nutrition

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Developmental Changes of Immunity and Different Responses to Weaning Stress of Chinese Indigenous Piglets and Duroc Piglets during Suckling and Weaning Periods

Cited by 6 publications

References 40 publications

Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning

Expressions of Insulin-like Growth Factor System among Different Breeds Impact Piglets’ Growth during Weaning

Combined effects of host genetics and diet on porcine intestinal fungi and their pathogenic genes

Development of small intestinal barrier function and underlying mechanism in Chinese indigenous and Duroc piglets during suckling and weaning periods

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