Developmental changes in the structure and function of lobster hemocyanin

Olson, Kirby S.

doi:10.1575/1912/5475

Cited by 2 publications

(1 citation statement)

References 65 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CANCER MAGISTER HEMOCYANIN The ontogeny of crustacean hemocyanin, the copper-based oxygen transport protein, has been studied in relatively few species, including Nephrops norvegicus (Spicer, 1995) and Homarus americanus (Olson, 1991). The most thoroughly studied system is the ontogeny of hemocyanin structure and function in Cancer magister, the Dungeness crab.…”

Section: Distribution Of Crustacean Oxygen Transport Proteinsmentioning

confidence: 99%

Ontogeny of Crustacean Respiratory Proteins1

Terwilliger

Ryan

2001

American Zoologist

View full text Add to dashboard Cite

SYNOPSIS. The respiratory proteins hemoglobin and hemocyanin share the function of oxygen transport, but the proteins belong to separate gene families, and their active sites and the metal ions that bind the oxygen differ. Either hemoglobin or hemocyanin, but not both, is expressed in the hemolymph of many arthropod crustaceans. Hemoglobin is present in Branchiopoda, Ostracoda, Copepoda, rhizocephalan Cirripedia and one suborder of amphipodan Malacostraca, while hemocyanin has been described in Malacostraca. Recent work by several laboratories have provided new information on the gene structure, exon-intron patterns, site of synthesis and expression of hemoglobins in the branchiopods Artemia and Daphnia. These studies suggest the branchiopods are excellent model organisms for studies of oxygen sensors and hypoxia inducible transcription factors during developmental and adult stages. The focus in our laboratory on the ontogeny of hemocyanin in the Dungeness crab, Cancer magister, has demonstrated that both structure and function of hemocyanin change from megalopa to adult crab. The hemocyanin of an oceanic megalopa contains four subunits. Another subunit appears about the time of metamorphosis to first juvenile instar, and expression of a sixth subunit begins four or five molts later. The timing of onset of adult hemocyanin can be altered experimentally by food levels and temperature. Gene expression and functional properties of both red and blue oxygen transport proteins of crustaceans change during ontogeny to insure oxygen delivery appropriate for each developmental stage.

show abstract

Section: Distribution Of Crustacean Oxygen Transport Proteinsmentioning

confidence: 99%