Developmental Changes in the Expression of TRPV1 Channels in Autonomic Nervous System Neurons

Korobkin, A. A.; Emanuilov, A. I.; Korzina, M. B.; Васильева, О. А.; Porseva, V. V.; Maslyukov, P. M.

doi:10.1007/s11055-013-9803-3

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…There are also age‐related changes in the expression of TRPV1 channels in sympathetic postganglionic neurons. The vast majority of neurons in the rat stellate ganglion contain TRPV1 channels, after which their proportion sharply decreases after 20 days of life (Korobkin et al, 2013). Changes in sympathetic postganglionic neurons are associated with the activation of the protein kinase C cascade due to capsaicin‐induced TRPV1 receptor stimulation in primary afferents (Xu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Neuronal nitric oxide synthase and calbindin expression in sympathetic preganglionic neurons following capsaicin treatment

Porseva

Preobrazhensky

2022

The Anatomical Record

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Along with well‐known data on the neurochemical mechanisms of nociceptor activation, there are still no clear data regarding changes in the cellular composition and morphological characteristics of spinal preganglionic neurons (SPN) after capsaicin treatment. The mechanism of capsaicin toxicity differs in developing and mature nerve cells. This study aimed to determine the number of SPN in the autonomic nuclei on spinal cord (SC) sections and their cross‐sectional area, the localization, percentage, and profile area of SPN containing neuronal nitric oxide synthase (nNOS) and calbindin (CB) in the thoracic SC of rats of different ages (from birth to 1‐year‐old) after capsaicin treatment. Neonatal capsaicin treatment generally decreased the cross‐sectional area of the SPN pericarya. However, the cross‐sectional area of the CB‐immunoreactive (IR) SPN increased in the central autonomic area in rats aged 10–30 days old after capsaicin treatment. The number of SPN decreased only in the central autonomic area of rats aged <20 days. The proportion of nNOS‐IR neurons remained steady and did not change during development. The cross‐sectional area of nNOS‐IR SPN in capsaicin‐treated rats was less than that in control rats. The results obtained will promote further studies on the mechanisms of sensory processing in the SC and the development of the sympathetic nervous system.

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Section: Discussionmentioning

confidence: 99%

Neuronal nitric oxide synthase and calbindin expression in sympathetic preganglionic neurons following capsaicin treatment

Porseva

Preobrazhensky

2022

The Anatomical Record

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“…The results of our study not only illed the gap in the previous study on the effect of very low concentration of sevoflurane on respiratory system, which conirmed that sevolurane at residual concentration during anesthetic resuscitation could also activate TRPV1, but also further found that this effect was age-dependent, which is that the effect of sevoflurane up-regulating TRPV1 in the respiratory system of developing rats (14 d and 21 d rats) was not found in adult rats (42 d rats). It is speculated that compared with the adult respiratory system, the sensory nerve endings of the developing airway epithelium have more TRPV1, but the airway epithelium is immature, so the nerve endings and TRPV1 are more likely to be exposed to the external environment and activated by sevolurane (Korobkin AA, et al, 2013). When TRPV1 channel is activated, triggered Ca 2+ influx causes C-fiber to release sensory neuropeptides (NKA, NKB, CGRP, SP) through axonal reflex.…”

Section: Al 2008mentioning

confidence: 99%

The expanded effects of sevoflurane on the nervous system: the harmful effect of residual concentration of sevoflurane on the respiratory system through neurogenic inflammation

Wang¹,

Zhang²,

Zhou³

et al. 2021

Ibrain

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Background Neurogenic inflammation caused by sevoflurane may not only limite to the nervous system, but also expand to the respiratory system. The purpose of this study was to investigate the expression changes of transient receptor potential vanilloid 1 (TRPV1), neurokinin A (NKA), neurokinin B (NKB), calcitonin gene related peptide (CGRP) and substance P (SP) in 14, 21 and 42‐day‐old rats after inhaling 0.4% sevoflurane, in order to evaluate whether the residual sevoflurane be harmful to the respiratory system through neurogenic inflammation. Methods The anesthetic inhalation device was designed to allow 14, 21 and 42‐day‐old rats inhale 0.4% sevoflurane, while rats in the control group inhaled 40% O2 for 1h. Rats in the antagonist group inhaled 0.4% sevoflurane or 40% O2 for 1 h after Capsazepine (CPZ) pretreatment. The expression of TRPV1 in lung tissue was detected by western blot, and the expression of NKA, NKB, CGRP and SP in trachea was detected by immunohistochemistry. Results After inhaling 0.4% sevoflurane, the expression of TRPV1 in lung tissue of 14 and 21‐day‐old rats was significantly higher than that of the control group, as well as increased the expression of CGRP and SP in the trachea of 14‐day‐old rats and NKA, NKB, CGRP and SP in the trachea of 21‐day‐old rats. CPZ pretreatment could antagonize these effects. Conclusion Residual sevoflurane during resuscitation of inhalation anesthesia could induce neurogenic inflammation by activating TRPV1, which damaged to the developing respiratory system, but has no significant effect on the respiratory system in adulthood.

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“…Newborn infants are structurally and functionally immature; development continues throughout the first year of life . For example, during development of the dorsal root ganglion, the proportion of TRPV1‐expressing cells increased in the rat until 20 days postnatally . During postnatal skin development, the leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6), identified as a marker of adult stem cells responsible for renewal of sebaceous glands and skin, is expressed .…”

Section: Introductionmentioning

confidence: 99%

Capsaicin induces atopic dermatitis‐like manifestations through dysregulation of proteolytic system and alteration of filaggrin processing in rats

Kim

Back²,

et al. 2018

Experimental Dermatology

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Atopic dermatitis (AD) is a complex disease featuring pruritic skin inflammation. Many animal models have been developed. In a rat model, subcutaneous capsaicin injection within 48 hours after birth induces AD-like skin manifestations of dermatitis and scratching behaviour 3 weeks after the injection. When 2- to 4-week-old rats were injected with capsaicin, the lag period was shortened, and the severity of skin manifestations was significantly reduced, suggesting influences of postnatal development. Lgr6 is an epidermal stem cell marker that is normally restricted to the isthmus area of hair follicles at postnatal 2 weeks. Lgr6 persisted in the interfollicular epidermis of capsaicin-injected rats beyond 3 weeks after birth, indicating that capsaicin-induced skin manifestations were influenced by postnatal epidermal development. Capsaicin injection induced alteration of proteolytic processing of filaggrin and corneodesmosin, suggesting epidermal barrier dysfunction. Inappropriate degradation of matriptase was observed. Degrees of proteolysis of these proteins were corelated with the severity of manifestations, suggesting that inappropriate proteolysis might be a possible cause of the skin manifestations. These results strongly suggest that capsaicin may dysregulate the protease system, resulting in alteration of profilaggrin and corneodesmosin proteolysis and skin manifestations. These events may be influenced by postnatal epidermal development.

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Developmental Changes in the Expression of TRPV1 Channels in Autonomic Nervous System Neurons

Cited by 7 publications

References 10 publications

Neuronal nitric oxide synthase and calbindin expression in sympathetic preganglionic neurons following capsaicin treatment

Neuronal nitric oxide synthase and calbindin expression in sympathetic preganglionic neurons following capsaicin treatment

The expanded effects of sevoflurane on the nervous system: the harmful effect of residual concentration of sevoflurane on the respiratory system through neurogenic inflammation

Capsaicin induces atopic dermatitis‐like manifestations through dysregulation of proteolytic system and alteration of filaggrin processing in rats

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