Developmental changes in reactivity of small femoral arteries in the fetal and postnatal baboon

Anwar, Mumtaz Ali; Ju, Kimberly; Docherty, Cheryl C.; Poston, Lucilla; Nathanielsz, Peter W.

doi:10.1067/mob.2001.111159

Cited by 10 publications

(6 citation statements)

References 14 publications

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“…Developmental changes in the expression of vascular AT 1 receptors and of renal V 1 receptors have been observed in fetal sheep and fetal rats, respectively (Ostrowski et al 1993; Wintour et al 1999; Cox & Rosenfeld, 1999; Burrell et al 2001). Additional in vitro experiments have shown that the maximum vasoconstrictor responses to potassium, noradrenaline and endothelin‐1 also increase with advancing gestational age in small branches of femoral arteries isolated from baboon and sheep fetuses (Anwar et al 2001; Docherty et al 2001 b ).…”

Section: Discussionmentioning

confidence: 99%

“…This increases the perfusion pressure of the fetal vascular tree and the responsiveness of the heart and circulation to variations in arterial blood pressure. Studies in vitro have also shown that there are maturational changes in regional vascular reactivity (Anwar et al 2001; Docherty et al 2001 b ). Combined, therefore, these developmental changes in cardiovascular function ensure that the delivery of oxygen and nutrients to the fetal tissues is appropriate for their mass and nutrient requirements during normal conditions or episodes of stress.…”

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confidence: 99%

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Development of baroreflex function and hind limb vascular reactivity in the horse fetus

O’Connor

Ousey

Gardner

et al. 2006

The Journal of Physiology

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This study investigated, in vivo, the mechanisms underlying the development of cardiovascular function in the horse fetus, with particular relevance to baroreflex function and hind limb vascular arterial reactivity to constrictor agonists. Under general anaesthesia, vascular catheters were inserted and a Transonic flow probe was implanted around one of the metatarsal arteries of 13 horse fetuses, either at 0.6 of gestation (n = 6) or at 0.9 of gestation (n = 7, term ∼335 days). At least 5 days after surgery, pressor, vasoconstrictor and cardiac chronotropic responses to exogenous bolus doses of phenylephrine, angiotensin II and arginine vasopressin were recorded. Fetal cardiac baroreflex slopes were obtained using the peak pressor and heart rate responses to increasing doses of phenylephrine. Fetal treatment with phenylephrine, angiotensin II and vasopressin produced significant changes in arterial blood pressure, hind limb vascular resistance and heart rate. Pressor and vasopressor responses to all agonists were greater at 0.9 than at 0.6 of gestation; however, fetal cardiac baroreflex sensitivity decreased with advancing gestational age. Correlation analysis revealed that fetal plasma cortisol rather than gestational age was a greater determinant of pressor and vasopressor reactivity. In contrast, gestational age rather than cortisol better determined heart rate and baroreflex responsiveness in the equine fetus. The data show that development of cardiovascular function in the equine fetus occurs via cortisol-dependent and -independent pathways.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Development of baroreflex function and hind limb vascular reactivity in the horse fetus

O’Connor

Ousey

Gardner

et al. 2006

The Journal of Physiology

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“…Little is known regarding when or how VSM contractile phenotypic diversity is generated during the development and maturation of the vascular system. That there may be developmental VSM phenotypic transitions is suggested by organspecific changes in vascular function in the transition from the in utero to mature circulation though this has received limited investigation (4,43,49). In the pig mesenteric circulation the vascular resistance increases and flow-mediated dilation/NO responses decrease in the neonatal transition from the fetal to adult circulation (146, 147, 183).…”

Section: Blood Vessel Developmentmentioning

confidence: 97%

Vascular smooth muscle phenotypic diversity and function

Fisher

2010

Physiological Genomics

141

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The control of force production in vascular smooth muscle is critical to the normal regulation of blood flow and pressure, and altered regulation is common to diseases such as hypertension, heart failure, and ischemia. A great deal has been learned about imbalances in vasoconstrictor and vasodilator signals, e.g., angiotensin, endothelin, norepinephrine, and nitric oxide, that regulate vascular tone in normal and disease contexts. In contrast there has been limited study of how the phenotypic state of the vascular smooth muscle cell may influence the contractile response to these signaling pathways dependent upon the developmental, tissue-specific (vascular bed) or disease context. Smooth, skeletal, and cardiac muscle lineages are traditionally classified into fast or slow sublineages based on rates of contraction and relaxation, recognizing that this simple dichotomy vastly underrepresents muscle phenotypic diversity. A great deal has been learned about developmental specification of the striated muscle sublineages and their phenotypic interconversions in the mature animal under the control of mechanical load, neural input, and hormones. In contrast there has been relatively limited study of smooth muscle contractile phenotypic diversity. This is surprising given the number of diseases in which smooth muscle contractile dysfunction plays a key role. This review focuses on smooth muscle contractile phenotypic diversity in the vascular system, how it is generated, and how it may determine vascular function in developmental and disease contexts.

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“…The contractile response mediated by KCl was evaluated in the SPA of rats exposed to CIHH and a control group. This indirectly measures the muscularization of the SPA used in the study based on their R MAX to KCl (Pearce et al, 1991;Wagerle et al, 1995;Anwar et al, 2001). Tolerant and intolerant rats had a higher vasoconstrictor response to potassium compared with the control group ( Fig.…”

Section: Ex Vivo Spamentioning

confidence: 99%

“…Pulmonary circulation is sensitive to the lack of oxygen, which promotes hypoxia pulmonary vasoconstriction and pathological remodeling which is characterized by pulmonary artery wall thickening (Makino et al, 2011). Studies have reported a direct relationship between R MAX and femoral artery muscle mass (Anwar et al, 2001) and a positive correlation between the maximum potassium response and vascular wall thickness (Pearce et al, 1991;Wagerle et al, 1995). Also, unpublished studies from our laboratory showed that rats exposed to chronic and intermittent normobaric hypoxia, during 1 month at 3500 m, presented vascular wall thickening of the main pulmonary artery which was related to the potassium R MAX .…”

Section: Cihh and The Vasoconstriction Response To Kcl In Spamentioning

confidence: 99%

Chronic Intermittent Hypobaric Hypoxia (4600 M) Attenuates Pulmonary Vasodilation Induced by Acetylcholine or Sodium Nitroprusside

Moraga

Miranda

López

et al. 2018

High Altitude Medicine & Biology

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Developmental changes in reactivity of small femoral arteries in the fetal and postnatal baboon

Cited by 10 publications

References 14 publications

Development of baroreflex function and hind limb vascular reactivity in the horse fetus

Development of baroreflex function and hind limb vascular reactivity in the horse fetus

Vascular smooth muscle phenotypic diversity and function

Chronic Intermittent Hypobaric Hypoxia (4600 M) Attenuates Pulmonary Vasodilation Induced by Acetylcholine or Sodium Nitroprusside

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