Developmental changes in pharmacokinetics and pharmacodynamics of warfarin enantiomers in Japanese children

Abstract

Liver weight may be a better parameter than body weight for estimating the warfarin doses for prepubertal patients on the basis of the corresponding adult values. Augmented responses to warfarin in children should also be taken into account for estimating warfarin doses for children.

Effect of Host Genetic Variation on the Pharmacokinetics and Clinical Response of Nnrtis

“…This is also supported by studies showing that the clearance of CYP substrates including warfarin [61], antipyrine [62], and nelfinavir [63,64] are increased in young children. Therefore, we examined if the CYP2B6-G516T genotype in young children would have a greater impact on EFV oral clearance than older children [21,23].…”

Vitamin K antagonists in children with heart disease: height and VKORC1 genotype are the main determinants of the warfarin dose requirement

“…[4][5][6][7][8][9][10][11][12][13][14][15] In contrast, only a few small studies have investigated the effect of the VKORC1 and/or CYP2C9 genotype on VKA dose requirements in children. [24][25][26][27][28] Moreover, no study evaluated the potential influence of pharmacogenetic variables on anticoagulation control.…”

Prescribing practices for pediatric out-patients: A case study of two teaching hospitals in Nigeria

“…The high incidence of death seen in children may be due to the fact that most medications used in the care of this group of patients are formulated and packaged primarily for adults and children may not be able to communicate effectively with providers [6]. Moreover, children's renal, immune and hepatic functions are not well developed, thus creating pharmacokinetic and pharmacodynamic differences that predispose them to adverse drugs reactions and drug harm [6,9]. In view of these problems, there is need for good evidencebased prescribing to ensure appropriate use of drugs in patients and patient safety.…”