Developmental changes in KCC1, KCC2 and NKCC1 mRNAs in the rat cerebellum

Mikawa, Sumiko; Wang, Cong; Fang, Shu; Wang, Tao; Fukuda, Atsuo; Sato, Kohji

doi:10.1016/s0165-3806(02)00345-0

Cited by 86 publications

(79 citation statements)

References 20 publications

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“…Interestingly, the FK-up genes include many neurotransmitter receptors, ion channels, and transporters. The GABA A ␣1, GABA A ␣6, and GABA A ␦ subunits of GABA receptors, the NR2C subunit of NMDA receptors, the TASK-1 channel, and the KCC2 transporter have been shown to be highly expressed in mature granule cells (21,22,24,25). The CaN signaling thus coordinately controls the expression of fundamental components in synaptic transmission of postmigratory granule cells and may contribute to the maturation and refinement of cerebellar circuit formation.…”

Section: Discussionmentioning

confidence: 99%

“…A few of the FK-up genes, including NR2C, GABA A ␣1, GABA A ␣6, GABA A ␦, Wnt7a, Tiam1, TASK-1, and KCC2 genes, have been shown to be predominantly expressed in the IGL and up-regulated in the cerebellum during postnatal development (5,(21)(22)(23)(24)(25). In contrast, doublecortin, Homer2, MARCKS-like protein, caspase-3, and VGluT2 genes, which are all FK-down genes, have been reported to be significantly expressed in the EGL during the postnatal period (26)(27)(28)(29)(30).…”

Section: Expression Of Fk506-responsive Genes In Premigratory and Posmentioning

confidence: 99%

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A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Sato

Suzuki²,

Yamazaki³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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Section: Discussionmentioning

confidence: 99%

Section: Expression Of Fk506-responsive Genes In Premigratory and Posmentioning

confidence: 99%

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Sato

Suzuki²,

Yamazaki³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

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“…Developing neurons exhibit an [Cl Ϫ ] i that is maintained above its electrochemical potential equilibrium, whereas mature neurons exhibit [Cl Ϫ ] i below its potential equilibrium. As Figure 20 shows, change from excitatory in prenatal life to inhibitory in postnatal life is associated with BSC2/ NKCC1 downregulation together with KCC2 upregulation after birth (59,243,278,328). In early development, BSC2/ NKCC1 appears to be the primary transporter responsible for high intraneuronal Cl Ϫ concentration.…”

Section: Basolateral Bumetanide-sensitive Namentioning

confidence: 99%

Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters

Gamba

2005

Physiological Reviews

690

754

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Electroneutral cation-Cl−cotransporters compose a family of solute carriers in which cation (Na+or K+) movement through the plasma membrane is always accompanied by Cl−in a 1:1 stoichiometry. Seven well-characterized members include one gene encoding the thiazide-sensitive Na+−Cl−cotransporter, two genes encoding loop diuretic-sensitive Na+−K+−2Cl−cotransporters, and four genes encoding K+−Cl−cotransporters. These membrane proteins are involved in several physiological activities including transepithelial ion absorption and secretion, cell volume regulation, and setting intracellular Cl−concentration below or above its electrochemical potential equilibrium. In addition, members of this family play an important role in cardiovascular and neuronal pharmacology and pathophysiology. Some of these cotransporters serve as targets for loop diuretics and thiazide-type diuretics, which are among the most commonly prescribed drugs in the world, and inactivating mutations of three members of the family cause inherited diseases such as Bartter's, Gitelman's, and Anderman's diseases. Major advances have been made in the past decade as consequences of molecular identification of all members in this family. This work is a comprehensive review of the knowledge that has evolved in this area and includes molecular biology of each gene, functional properties of identified cotransporters, structure-function relationships, and physiological and pathophysiological roles of each cotransporter.

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“…In the present study, we focused on the Purkinje cell, which is a principal and first-differentiating neuron in the cerebellar cortex. Although developmental expression of the KCC2 in the cerebellum had previously been investigated using in situ hybridization (Mikawa et al, 2002), little is known about when Purkinje cells start to express the KCC2 during development. To clarify the time-course of the changes in GABA actions during Purkinje cell development, we examined the developmental localization of the KCC2 in the embryonic mouse cerebellum.…”

mentioning

confidence: 99%

Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

Takayama

Inoue

2007

Neuroscience Research

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Developmental shift in GABA actions from depolarization to hyperpolarization occurs as a result of decreasing the intracellular Cl− concentration regulated by K+-Cl− co-transporter 2 (KCC2). To clarify the time-course of the developmental shift on the Purkinje cells, we examined KCC2-localization in the embryonic mouse cerebellum. The KCC2 was first detected within the Purkinje cells in the Purkinje cell layer of the hemisphere at embryonic day 15 (E15) and the vermis at E17, but the ventricular and intermediate zones were negative. These results suggest that GABA might become inhibitory on the Purkinje cells after their settling in the Purkinje cell layer

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Developmental changes in KCC1, KCC2 and NKCC1 mRNAs in the rat cerebellum

Cited by 86 publications

References 20 publications

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

A pivotal role of calcineurin signaling in development and maturation of postnatal cerebellar granule cells

Molecular Physiology and Pathophysiology of Electroneutral Cation-Chloride Cotransporters

Developmental localization of potassium chloride co-transporter 2 (KCC2) in the Purkinje cells of embryonic mouse cerebellum

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