Developmental Changes in Dopamine Modulation of the Heart in the Isopod Crustacean Ligia exotica: Reversal of Chronotropic Effect

Yamagishi, Hiroshi; Miyamoto, Hiroshi; Sakurai, Akira

doi:10.2108/zsj.21.917

Cited by 2 publications

(2 citation statements)

References 19 publications

(20 reference statements)

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“…Similar developmentally specific dopaminergic effects on HR have also been reported in the sea roach, L. exotica (Yamagishi et al. ). Moreover DA has a positive chronotropic effect on the cockroach heart (Collins and Miller ).…”

Section: Discussionsupporting

confidence: 76%

“…Using intact P1 pupal stage from the Canton S line, Johnson et al (1997) observed that DA has a positive chronotropic effect. Similar developmentally specific dopaminergic effects on HR have also been reported in the sea roach, L. exotica (Yamagishi et al 2004a). Moreover DA has a positive chronotropic effect on the cockroach heart (Collins and Miller 1977).…”

Section: Discussionsupporting

confidence: 59%

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Pharmacological analysis of dopamine modulation in theDrosophila melanogasterlarval heart

et al. 2013

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Dopamine (DA) and other neurotransmitters affect nonneuronal tissues in insects by circulating in the hemolymph. In several organisms, DA has been shown to modulate distinct aspects of cardiac function but the signal transduction pathways that mediate dopaminergic effects on the heart are not well characterized. Here, we used a semiintact Drosophila melanogaster larva preparation and drugs targeting DA receptors and canonical second messenger pathways to identify signaling cascades that mediate the effect of DA on a myogenic heart. DA has a positive chronotropic effect that is mimicked by SKF38393 (type-1 DA receptor agonist) and quinpirole (type-2 DA receptor agonist). SCH23390 and spiperone (type-1 and type-2 DA receptor antagonists) are moderately effective at inhibiting DA's effect. An adenylate cyclase inhibitor (SQ,22536) is also effective at blocking the stimulatory effect of DA but the drug has its own dose-dependent effect. Activation of protein kinase C with a diacylglycerol analog has a stimulatory effect on heart rate (HR). These results suggest that (1) both DA receptor subtypes are expressed in third instar larva cardiac myocytes to increase HR in response to rising levels of DA in the hemolymph, and (2) canonical second messenger pathways modulate HR in D. melanogaster larvae. Having these disparate signaling cascades converge toward a common modulatory function appears redundant, but in the context of multiple cardioactive chemicals this redundancy is likely to increase the fidelity of signal transduction.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 59%

Pharmacological analysis of dopamine modulation in theDrosophila melanogasterlarval heart

et al. 2013

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Developmental Changes in Heart Photosensitivity of the Isopod Crustacean Ligia exotica

et al. 2007

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During juvenile development, the cardiac pacemaker of the isopod crustacean Ligia exotica is transferred from the myocardium to the cardiac ganglion of the neurogenic heart. In adult, light stimulus decreases the beat frequency of the heart. To elucidate developmental changes in the photosensitivity of the juvenile Ligia heart, we examined the effect of a light stimulus on the semi-isolated heart of juveniles at various developmental stages by the recording membrane potential of the myocardium. We also examined the effect of hyperpolarizing current injection into the myocardium, because this causes different effects on the beat frequency between myogenic and neurogenic hearts. In newly hatched juveniles, beat frequency decreased upon current injection but exhibited no response to white light. In contrast, 10 days after hatching, beat frequency did not change upon current injection, but decreased in response to white light. The heart photoresponse of juveniles was reversibly eliminated by application of tetrodotoxin, which changes the heartbeat from neurogenic to myogenic by suppressing cardiac ganglion activity. The proportion of juveniles exhibiting a heart photoresponse increased gradually up to 100% during the period between 3 and 10 days after hatching. The results suggest that the heart photoresponse of L. exotica appears in association with transfer of the cardiac pacemaker from the myocardium to the cardiac ganglion during juvenile development.

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Developmental Changes in Dopamine Modulation of the Heart in the Isopod Crustacean Ligia exotica: Reversal of Chronotropic Effect

Cited by 2 publications

References 19 publications

Pharmacological analysis of dopamine modulation in theDrosophila melanogasterlarval heart

Pharmacological analysis of dopamine modulation in theDrosophila melanogasterlarval heart

Developmental Changes in Heart Photosensitivity of the Isopod Crustacean Ligia exotica

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