Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

Nussenbaum, Kate; Hartley, Catherine A.

doi:10.7554/elife.69796

Cited by 10 publications

(7 citation statements)

References 119 publications

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“…Consistent with previous research in adults, we found increased brain activation in several cortical areas and the thalamus across participants of all ages for encoding high-relative to lowreward associations (Wittmann et al, 2005;Cohen et al, 2014;. We focused specifically on observed dlPFC activation given both prior work in adults underscoring its role in driving reward-motivated behaviors (Ballard et al, 2011), as well as evidence of its protracted developmental trajectory (Mills et al, 2014) and increasing contributions to memory encoding with age (Menon et al, 2005;Ofen et al, 2007;Ghetti et al, 2010;Nussenbaum and Hartley, 2021). We found that dlPFC activation was related to high-reward specific associative memory benefits 24 hours after encoding across all participants.…”

Section: Discussionsupporting

confidence: 82%

Reward Enhances Memory via Age-Varying Online and Offline Neural Mechanisms across Development

et al. 2022

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Reward motivation enhances memory through interactions between mesolimbic, hippocampal, and cortical systemsboth during and after encoding. Developmental changes in these distributed neural circuits may lead to age-related differences in reward-motivated memory and the underlying neural mechanisms. Converging evidence from cross-species studies suggests that subcortical dopamine signaling is increased during adolescence, which may lead to stronger memory representations of rewarding, relative to mundane, events and changes in the contributions of underlying subcortical and cortical brain mechanisms across age. Here, we used fMRI to examine how reward motivation influences the "online" encoding and "offline" postencoding brain mechanisms that support long-term associative memory from childhood to adulthood. We found that reward motivation led to both age-invariant as well as adolescentspecific enhancements in associative memory after 24 hours. Furthermore, reward-related memory benefits were linked to age-varying neural mechanisms. During encoding, interactions between the prefrontal cortex and ventral tegmental area (VTA) were associated with better highreward memory to a greater degree with increasing age. Pre-to post-encoding changes in functional connectivity between the anterior hippocampus and VTA were also associated with better high-reward memory, but more so at younger ages. Our findings suggest that there may be developmental shiftsfrom offline subcortical to online cortical processesin the brain mechanisms supporting reward-motivated memory.

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Section: Discussionsupporting

confidence: 82%

Reward Enhances Memory via Age-Varying Online and Offline Neural Mechanisms across Development

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Consistent with previous research in adults, we found increased brain activation in several cortical areas and the thalamus across participants of all ages for encoding high-relative to lowreward associations (Wittmann et al, 2005;Cohen et al, 2014;. We focused specifically on observed dlPFC activation given both prior work in adults underscoring its role in driving reward-motivated behaviors (Ballard et al, 2011), as well as evidence of its protracted developmental trajectory (Mills et al, 2014) and increasing contributions to memory encoding with age (Menon et al, 2005;Ofen et al, 2007;Ghetti et al, 2010;Nussenbaum and Hartley, 2021). We found that dlPFC activation was related to high-reward specific source memory benefits 24 hours after encoding across all participants.…”

Section: Discussionsupporting

confidence: 82%

Reward enhances memory via age-varying online and offline neural mechanisms across development

Cohen

Glover

Shen

et al. 2021

Preprint

Self Cite

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Reward motivation enhances memory through interactions between mesolimbic, hippocampal, and cortical systems - both during and after encoding. Developmental changes in these distributed neural circuits may lead to age-related differences in reward-motivated memory and the underlying neural mechanisms. Converging evidence from cross-species studies suggests that subcortical dopamine signaling is increased during adolescence, which may lead to stronger memory representations of rewarding, relative to mundane, events and changes in the contributions of underlying subcortical and cortical brain mechanisms across age. Here, we used fMRI to examine how reward motivation influences the "online" encoding and "offline" post-encoding brain mechanisms that support long-term associative memory from childhood to adulthood. We found that reward motivation led to both age-invariant as well as adolescent-specific enhancements in associative memory after 24 hours. Furthermore, reward-related memory benefits were linked to age-varying neural mechanisms. During encoding, interactions between the prefrontal cortex and ventral tegmental area (VTA) were associated with better high-reward memory to a greater degree with increasing age. Pre- to post-encoding changes in functional connectivity between the anterior hippocampus and VTA were also associated with better high-reward memory, but more so at younger ages. Our findings suggest that there may be developmental shifts - from offline subcortical to online cortical processes - in the brain mechanisms supporting reward-motivated memory.

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“…We speculate children's lack of differentiation reflects limitations in these prefrontal and hippocampal mechanisms. Prior work indicates strategic memory processes increase into adulthood (Bjorklund et al., 2009) and are associated with changes in prefrontal structure (Yu et al., 2018) and function (Nussenbaum & Hartley, 2021). There are also age‐related increases in the degree to which prefrontal function during encoding—perhaps reflecting engagement in strategies—predicts subsequent memory between late childhood and adulthood (Ofen et al., 2007; Shing et al., 2016; see Ghetti & Fandakova, 2020 for review).…”

Section: Discussionmentioning

confidence: 99%

Asynchronous development of memory integration and differentiation influences temporal memory organization

Coughlin,

Pudhiyidath,

Roome

et al. 2023

Developmental Science

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Adults remember items with shared contexts as occurring closer in time to one another than those associated with different contexts, even when their objective temporal distance is fixed. Such temporal memory biases are thought to reflect within‐event integration and between‐event differentiation processes that organize events according to their contextual similarities and differences, respectively. Within‐event integration and between‐event differentiation are hypothesized to differentially rely on binding and control processes, which may develop at different ages. To test this hypothesis, 5‐ to 12‐year‐olds and adults (N = 134) studied quartets of image pairs that contained either the same scene (same‐context) or different scenes (different‐context). Participants remembered same‐context items as occurring closer in time by older childhood (7–9 years), whereas different‐context items were remembered as occurring farther apart by early adolescence (10–12 years). The differential emergence of these temporal memory biases suggests within‐event integration and between‐event differentiation emerge at different ages.Research Highlights Children are less likely than adults to use contextual information (e.g., location) to organize their continuous experience in memory, as indicated by temporal memory biases. Biases reflecting within‐event integration (i.e., remembering elements with a shared context as occurring closer together in time) emerged in late childhood. Biases reflecting between‐event differentiation (i.e., remembering elements from different contexts as occurring farther apart in time) emerged in early adolescence. The differential emergence of biases reflecting within‐event integration and between‐event differentiation suggests they are distinct, yet complementary, processes that support developmental improvements in event memory organization.

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Developmental change in prefrontal cortex recruitment supports the emergence of value-guided memory

Cited by 10 publications

References 119 publications

Reward Enhances Memory via Age-Varying Online and Offline Neural Mechanisms across Development

Reward Enhances Memory via Age-Varying Online and Offline Neural Mechanisms across Development

Reward enhances memory via age-varying online and offline neural mechanisms across development

Asynchronous development of memory integration and differentiation influences temporal memory organization

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