AIM The aim of this study was to examine how fever during pregnancy is associated with motor development in the child.METHOD This cohort study was based on data from females and their children, from the Danish National Birth Cohort, who took part in an 18-month and/or 7-year follow-up study. Information regarding fever (number of episodes, temperature, duration, and pregnancy week) was obtained around gestation week 12 and at the end of pregnancy. Assessments of motor development in early childhood were based on the ages at which the motor milestones 'sitting unsupported' (n=44 256) and 'walking unassisted' (n=53 959) were attained. The Developmental Coordination Disorder Questionnaire 2007 (DCDQ'07) was used to identify children with indication of developmental coordination disorder (DCD) at age 7 years (n=29 401). Any associations between the exposure to fever during pregnancy and motor development were estimated using Cox regression and logistic regression analyses.RESULTS Fever during pregnancy was reported by 15 234 (28.0%) participants in the 18-month follow-up and by 7965 (26.9%) participants in the 7-year follow-up. Adjusted analyses showed no association between prenatal exposure to fever and either 'sitting unsupported' or 'walking unassisted'. The proportion of children with indication of DCD was 3.1%. The odds ratio of indication of DCD if children were exposed to fever in utero was 1.29 (95% CI 1.12-1.49). However, no dose-response association was found.
INTERPRETATIONWe found a significant association between maternal fever during pregnancy and DCD in children at age 7 years. The lack of a dose-response association might suggest that this association is explained by the underlying causes of the fever.Fever during pregnancy is suspected to increase the risk of several adverse outcomes in the developing fetus.1 In human studies, associations have been reported between prenatal fever exposure and neural tube defects, 1,2 congenital malformations including oral clefts, 3 and heart defects.
4A recent systematic review provides support for an adverse health impact on children after exposure to fever in utero; however, the authors conclude that the evidence of associations is insufficient for several of the outcomes addressed, and more cohort studies are needed. 5 In addition, results from animal studies have shown that exposure to hyperthermia in utero produces adverse outcomes in offspring. In 1967, Edwards 6 reported an increased incidence of fetal resorption and congenital malformations in guinea pigs exposed to hyperthermia during fetal life. Since then, animal studies have shown that hyperthermia is associated with fetal death, cardiovascular malformations, and a delayed myogenesis. [7][8][9] The development of the central nervous system appears to be particularly sensitive to elevated body temperatures, 7,10,11 and hyperthermia has been associated with the disruption of the production and migration of neuronal precursor cells and, thus, may result in abnormal brain development.
10A child's motor ab...