Developmental aspects of the renal kallikrein-like activity in fetal and newborn lambs

Robillard, J; Lawton, William J.; Weismann, Douglas N.; Sessions, Christine

doi:10.1038/ki.1982.217

Cited by 32 publications

(13 citation statements)

References 42 publications

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“…It has been shown previously that UKall excretion rate increases significantly during the last trimester of gestation (6). However, mechanisms regulating UKall production were not investigated.…”

Section: Discussionmentioning

confidence: 99%

“…UKall esterase activity was determined utilizing the artificial substrate of 3H-TAME (Amersham Corp., Arlington Heights, IL) (2,6). The tritiated methanol released by the esterase activity of urinary kallikrein was extracted and counted in a liquid scintillation counter (Beckman LS-220).…”

Section: Methodsmentioning

confidence: 99%

“…On the other hand, it has been demonstrated that UKall excretion rate increases significantly during the last trimester of gestation in fetal lambs (6). Since this rise correlated with an increase in plasma aldosterone concentration, it was suggested that aldosterone may be an important modulator of renal kallikrein production during renal maturation (6).…”

mentioning

confidence: 99%

“…Since this rise correlated with an increase in plasma aldosterone concentration, it was suggested that aldosterone may be an important modulator of renal kallikrein production during renal maturation (6).…”

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confidence: 99%

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Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

et al. 1985

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ABSTRACT. The present study was designed to investigate the effect of acute (2 h) and chronic aldosterone (4 days) infusion on urinary kallikrein excretion rate and on renal handling of Na+ and K+ in chronically catheterized fetal lambs e l 1 5 days gestation (n = 6) and >I25 days gestation (n = 7). Chronic aldosterone infusion decreased plasma renin activity in both groups of fetuses. Both acute and chronic aldosterone infusion produced significant decreases in UNa + V in fetuses >I25 days and in the majority of fetuses e l 1 5 days gestation (five of six). Aldosterone infusion did not increase K+ excretion in either group of fetuses. It is also demonstrated that chronic aldosterone infusion induced an increase in urinary kallikrein excretion rate in both groups of fetuses. Taken together, these results demonstrate that aldosterone has antinatriuretic but no kaliuretic effects during fetal life, but produces a rise in urinary kallikrein excretion rate during the last trimester of gestation in fetal lambs. (Pediatr Res 19: 1048-1052,1985 Abbreviations UKall, urinary kallikrein PRA, plasma renin activity HUK, human urinary kallikrein 'H-TAME, N-(p-tosy1)-1-arginine-PHI-methyl ester-hydrochlorideAldosterone acts on the kidney to increase sodium reabsorption in exchange for either potassium or hydrogen ion (I) and to stimulate renal kallikrein production (2). However, the role of aldosterone on the fetal renal function is not well defined. In respect to sodium metabolism, it has been shown that the percentage of filtered sodium excreted is elevated during fetal life (3,4) and in premature infants (5) suggesting a partial unresponsiveness of the distal nephron to aldosterone.On the other hand, it has been demonstrated that UKall excretion rate increases significantly during the last trimester of gestation in fetal lambs (6). Since this rise correlated with an increase in plasma aldosterone concentration, it was suggested that aldosterone may be an important modulator of renal kallikrein production during renal maturation (6).The present study was designed to explore in detail the effect of acute and chronic administration of aldosterone on UKall excretion rate during the last trimester of gestation in chronically Received April 5, 1985; accepted June 4, 1985 catheterized fetal lambs. Moreover, the quantitative relationship between plasma levels of aldosterone and renal handling of sodium and potassium was also evaluated. METHODSAnimal preparation and surgical procedures. The fetuses of 13 pregnant sheep of Dorset and Suffolk mixed breeding were studied. Six fetuses were between 99 and 107 days gestation (group I) and seven fetuses were between 125 and 13 1 days gestation (group 11) (term was 145 days) at the time of surgery. Gestational ages were based on the induced ovulation technique as described previously (7).Prior to surgery, the animals were fasted for 48 h. Anesthesia of the ewe and surgery of the fetus were performed as described previously (8). Briefly, the pregnant ewe was anesthetized using a mixture of...

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

et al. 1985

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“…Robillard et al [13]have demonstrated in fetal and newborn lambs that kallikrein excretion starts to increase during the last 25 days of gestation. Their study revealed a correlation between the rise in renal blood flow and kallikrein excretion.…”

Section: The Kks In the Developing Kidneymentioning

confidence: 99%

Bradykinin in the Newborn Kidney

Tóth-Heyn

Guignard

2002

Nephron

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The Kidney During Development

Spitzer

Schwartz

1992

Comprehensive Physiology

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The sections in this article are: Historical Perspective Standards of Reference for Comparison of Renal Function Between Infants and Adults Morphogenesis of the Kidney Embryologic Origin of the Kidney Subsequent Development of the Kidney Glomerulus Renal Tubule Renal Blood Flow and its Control During Development Total Renal Blood Flow Intrarenal Distribution of Blood Flow Renal Microvasculature Control of Renal Circulation Glomerular Filtration Net Ultrafiltration Pressure Hydraulic Conductivity and Ultrafiltration Coefficient Glomerular Capillary Surface Area Factors That Affect GFR during Development Autoregulation of GFR Renal Energy Metabolism Development of Renal Cortical Metabolic Pathways Tubular Functions Renal Reabsorption of Sodium Reabsorption of Bicarbonate and Excretion of Hydrogen Ions Glucose Transport Transport of Amino Acids Transport of Organic Acids Phosphate Transport Control of Renal Transport during Development Calcium Transport Magnesium Transport Potassium Transport Concentration of Urine Developmental Renal Physiology as A Tool for Understanding the Emergence and Integration of Renal Transport Systems

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Developmental aspects of the renal kallikrein-like activity in fetal and newborn lambs

Cited by 32 publications

References 42 publications

Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

Effects of Aldosterone on Urinary Kallikrein and Sodium Excretion during Fetal Life

Bradykinin in the Newborn Kidney

The Kidney During Development

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