Developmental Aspects of the Human Complement System

Sawyer, Mary Kirk; Forman, Marjorie L.; Kuplic, Linda S.; Stiehm, E.R.

doi:10.1159/000240409

Cited by 44 publications

(15 citation statements)

References 16 publications

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“…Even lower levels were observed in pre term than term infants, but the levels were not effected by intrauterine growth retardation. These results agree with those of others (2, 9) but, however, disagree with those of Sawyer et al (17) who found term infants to have normal levels of CH50, C3, C4 and C5 when compared to healthy adults. Because of the relative ab sence of C3 and factor B split products in the sera of the majority of our normal infants, it is at last possible to state, that the low CH50 activity and low component concentrations were developmental and not due to consump tion of factors which occurs with activation of the complement system by either the classical or the alternative pathways.…”

Section: Discussionsupporting

confidence: 83%

“…The increase in inci dence of infection has been related to differ ences in the immune mechanism of infants when compared to adults. Studies, including immunoglobulin synthesis (17), delayed hyper sensitivity (13), local antibody response (19), white cell function (11) and opsonin activity of the serum (14) have shown increasing degrees of impairment of the immune system with increas ing immaturity of these infants. Since comple ment is known to participate in several phases of mammalian defense against bacterial and viral invasion, it is reasonable to suppose that deficiencies or consumption of one or more complement components would be associated with increased susceptibility to infection.…”

Section: Introductionmentioning

confidence: 99%

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The Complement System of the Newborn Infant

Drew¹,

Arroyave²

1980

Neonatology

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Whole complement activity (CH50), and levels of some components of the classical (C1q, C4, C3) and alternative (factor B and properdin) pathways were determined in 55 non-infected and 11 infected newborn infants. Normal newborn infants were lower than adults in all complement measurements; pre term infants being significantly lower than term infants. Complement was not effected by intrauterine growth retardation. Absence of C3 split products indicated that the deficiencies were developmental and not due to activation of the complement system. Complement levels were lower in infected infants and this was due to activation of the complement system as C3 split products were present in 54%. Because of the high incidence of split products in infected infants, incorporating a test to determine their presence may be of benefit in the diagnosis of the presence of infection in newborn infants.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

The Complement System of the Newborn Infant

Drew¹,

Arroyave²

1980

Neonatology

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“…In the few reports also including studies of complement in low birth weight infants, classical as well as alternative complement activity have generally been found to be lower in low birth weight than in normal term infants (1,6,8,14,16). But it is not clear from these studies whether the defect of complement activity in low birth weight infants is the result of premature birth (6,8) or of intrauterine growth retardation (1,14,16). The purposes of the present study were to compare complement activity of both pathways in AGA and SGA low birth weight newborns, and to determine the influence of birth weight and gestational age on complement development in such infants.…”

Section: Discussionmentioning

confidence: 99%

“…Complement activity is lower in low birth weight infants than in term infants; however, the relationship of gestational age and/ or birth weight to the level of complement activity is still controversial (1,6,8,14,16). The purpose of the present study was to investigate the effects of birth weight and gestational age on complement development (CH50 and kinetics of both CP and AP, C3, and Factor B levels) in low birth weight infants divided into appropriate and small for gestational age groups.…”

mentioning

confidence: 99%

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

et al. 1984

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SummaryComplement activity was compared in 50 low birth weight infants divided into appropriate and small for gestational age groups; the influence of birth weight and gestational age on complement development was also investigated. CHW and kinetics (tHso) of both classical and alternative pathway activity of complement, C3, and Factor B levels were significantly higher in small for gestational age infants (classical pathway CHs, 630 HU/ml f 184 SD, C P tHs, 77 min + 47; aternative pathway CHS0, 44.8 HU/ml & 11.3; AP tHso, 56 min f 43; C3, 73.98 mg/dl f 12.68; and Factor B, 13.17 mg/dl 2 3.67) than in weight-matched appropriate for gestational age infants (CP CHW, 523 HU/ml 2 152; C P tH9, 105 min + 49; AP CHW, 38.8 HU/ml f 13; AP tHW, 90 min 2 53; C3, 58.14 mg/dl f 9.43; and Factor B, 9.32 mg/dl+ 1.73). Complement values were lower in low birth weight infants than in adult controls ( P < 0.001 in all cases). All complement parameters were mainly correlated with gestational age; CHso values of the classical and alternative pathways were also highly correlated with each other

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“…The main reason for these discrepancies lies in the use of different assays, different types of particles, particle size, and different serum concentrations. Concentrations of complement components important for the opsonization of various microorganisms in newborns were found to be relatively low compared with the levels in adults; however, normal and even elevated levels of complement proteins have also been reported (18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

mentioning

confidence: 99%

Opsonic Activity of Cord Blood Sera against Various Species of Microorganism

et al. 1985

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ABSTRACT. The results of the present study on the opsonic activity of cord blood serum against various microorganisms (Staphylococcus aureus, Escherichia coli, and group B streptococci) show that the activity of cord blood serum in promoting IgG-mediated ingestion is equal to that of sera of healthy adults. This implies that IgG concentrations, as assessed by immunochemical methods, in cord blood and adult sera represent functionally similar IgG activities. Ingestion of microorganisms involving complement-dependent opsonization was found to be of the same level for cord blood and adult sera, when the opsonization occurred via the classical pathway of complement activation. However, due to decreased concentrations of factors B, P, and D in cord blood serum, optimal opsonization of microorganisms requiring the alternative pathway of complement was impaired. Taken together, these results indicate that an opsonic defect of cord blood serum affects mainly microorganisms requiring opsonization via the alternative pathway of complement. (Pediatr Res 19: [433][434][435][436]1985)

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Developmental Aspects of the Human Complement System

Cited by 44 publications

References 16 publications

The Complement System of the Newborn Infant

The Complement System of the Newborn Infant

Activity of Classical and Alternative Pathways of Complement in Preterm and Small for Gestational Age Infants

Opsonic Activity of Cord Blood Sera against Various Species of Microorganism

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