Developmental and Pediatric Lung Disease

Dishop, Megan K.

doi:10.1016/b978-0-323-44284-8.00005-3

Cited by 3 publications

(4 citation statements)

References 154 publications

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“…On the other hand, the isolated affection of one lung lobe (or only part of a lobe) is observed in circumscribed tumours (e.g. chondrohamartoma, teratoma and others), lung sequestration, cysts, emphysematous bullae and localized inflammation (pneumonia) [ 23 ] The CT-scans exclude a circumscribed mass, such as in tumours, cysts or emphysematous bullae so that finally the differential diagnosis leaves lung sequestration and localized pneumonia as differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Taking into account that lung sequestration is a very rare disorder and usually shows affection of only a small portion of the lung lobe [ 23 ], the pneumonic inflammatory infiltration is the most probable diagnosis. Pneumonia mostly is the result of aerogenic bacterial infection affecting a part of the lung (bronchopneumonia) or a complete lobe (lobar pneumonia) [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

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The infant mummy’s face—Paleoradiological investigation and comparison between facial reconstruction and mummy portrait of a Roman-period Egyptian child

Nerlich

Fischer²,

Panzer

et al. 2020

PLoS ONE

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In Graeco-Roman times in the Lower-Egyptian Fayoum region, a painted portrait was traditionally placed over the face of a deceased individual. These mummy portraits show considerable inter-individual diversity. This suggests that those portraits were created separately for each individual. In the present study, we investigated a completely wrapped young infant mummy with a typical mummy portrait by whole body CT analysis. This was used to obtain physical information on the infant and provided the basis for a virtual face reconstruction in order to compare it to the mummy portrait. We identified the mummy as a 3–4 years old male infant that had been prepared according to the typical ancient Egyptian mummification rites. It most probably suffered from a right-sided pulmonary infection which may also be the cause of death. The reconstructed face showed considerable similarities to the portrait, confirming the portrait’s specificity to this individual. However, there are some differences between portrait and face. The portrait seems to show a slightly older individual which may be due to artistic conventions of that period.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The infant mummy’s face—Paleoradiological investigation and comparison between facial reconstruction and mummy portrait of a Roman-period Egyptian child

Nerlich

Fischer²,

Panzer

et al. 2020

PLoS ONE

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“…Preeclampsia is one of the leading causes of premature birth. As a result of premature birth, there are a number of complications that result in significant morbidity and mortality, including bronchopulmonary dysplasia (BPD), hyaline membrane disease, and pulmonary interstitial emphysema [ 89 ]. A recent study has documented a circRNA expression profile associated with preterm birth, and preliminarily analyzed its regulatory mechanism and predictive value for preterm birth [ 90 ].…”

Section: Circrna and Risk Factors Of Developmental And Pediatric Lung...mentioning

confidence: 99%

Circular RNAs in the Origin of Developmental Lung Disease: Promising Diagnostic and Therapeutic Biomarkers

et al. 2023

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Circular RNA (circRNA) is a newly discovered noncoding RNA that regulates gene transcription, binds to RNA-related proteins, and encodes protein microRNAs (miRNAs). The development of molecular biomarkers such as circRNAs holds great promise in the diagnosis and prognosis of clinical disorders. Importantly, circRNA-mediated maternal-fetus risk factors including environmental (high altitude), maternal (preeclampsia, smoking, and chorioamnionitis), placental, and fetal (preterm birth and low birth weight) factors are the early origins and likely to contribute to the occurrence and progression of developmental and pediatric cardiopulmonary disorders. Although studies of circRNAs in normal cardiopulmonary development and developmental diseases have just begun, some studies have revealed their expression patterns. Here, we provide an overview of circRNAs’ biogenesis and biological functions. Furthermore, this review aims to emphasize the importance of circRNAs in maternal-fetus risk factors. Likewise, the potential biomarker and therapeutic target of circRNAs in developmental and pediatric lung diseases are explored.

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“…Morphogenesis, the process by which an organism or its tissues shape themselves, has long captured the attention of scientists seeking to unravel the fascinating process of creating whole organisms. As developmental processes going awry cause many diseases, understanding them is of critical importance [1][2][3][4] . Because of the non-linear behaviours of many morphogenetic systems, theoretical modelling is often very beneficial when trying to understand these complex systems, distilling the core mechanisms that explain a morphogenetic phenomenon 5,6 However, this is only true when such efforts occur in close collaboration with a domain expert 7 , which ensures that the observed behaviour of the model is as accurate as possible.…”

Section: Morphogenesis and Angiogenesismentioning

confidence: 99%

Creating an accessible and understandable modelling language for cell-based simulations

Mead

2020

Proceedings of the 23rd ACM/IEEE International Conference on Model Driven Engineering Languages and Systems: Companion Proceedi

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The study of morphogenesis has increasingly entailed the use of computer simulations to predict intricate behaviours from these systems, which has led to the development of tools for computational biologists to build their own simulations. However, uptake of these tools by experimental biologists has been slow and concerns remain over the assumptions underlying such tools, which are not readily explicable to a domain expert without prior programming knowledge. To demonstrate how these concerns might be addressed, we propose the creation of a domain-specific language (DSL) of one such simulation, the MemAgent-Spring model (MSM). By designing this DSL around regimented biological concepts identified by observing discussions between experimentalists and modellers, we hope to better understand how the usability and reproducibility of the MSM might be improved, therefore potentially increasing its usage by experimentalists. CCS CONCEPTS • Applied computing~Life and medical sciences~Computational biology • Human-centered computing~Interaction design~Empirical studies in interaction design • Software and its engineering~Software notations and tools~Context specific languages~Domain specific languages

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Developmental and Pediatric Lung Disease

Cited by 3 publications

References 154 publications

The infant mummy’s face—Paleoradiological investigation and comparison between facial reconstruction and mummy portrait of a Roman-period Egyptian child

The infant mummy’s face—Paleoradiological investigation and comparison between facial reconstruction and mummy portrait of a Roman-period Egyptian child

Circular RNAs in the Origin of Developmental Lung Disease: Promising Diagnostic and Therapeutic Biomarkers

Creating an accessible and understandable modelling language for cell-based simulations

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