Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus

Kim, Jin-Wook; Son, Yeonghoon; Kim, Juhwan; Lee, Sueun; Kang, Sohi; Park, Kyung-Hwan; Kim, Sung Hoon; Kim, Jong-Choon; Kim, Jeong-Tae; Takayama, Chitoshi; Im, Heh‐In; Yang, Miyoung; Shin, Taekyun; Moon, Changjong

doi:10.1016/j.ijdevneu.2015.08.009

Cited by 16 publications

(5 citation statements)

References 99 publications

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“…We found that the GABAergic neurotransmission counteracts spatial memory and LTP in the hippocampus. A critical role of the GABAergic transmission in memory formation and synaptic plasticity has been already described (Bonansco & Fuenzalida, 2016; Kim, Son, et al, 2015). Also, Hu et al demonstrated that chronic stress increases GABAergic transmission in the hippocampus (Hu et al, 2010).…”

Section: Discussionmentioning

confidence: 81%

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Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission

Bidgoli

Salami

Talaei

2020

Intl J of Devlp Neuroscience

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Evidence shows that prenatal stress negatively affects cognitive functions and activity of neuronal circuits in postnatal age. Environmental enrichment counteracts deficits induced by early life stress. We examined if behavioural function and synaptic plasticity are sensitive to prenatal stress and, how much environmental enrichment and GABAergic system impact these phenomena. Animals were exposed to noise stress during the third trimester of foetal life. Groups of the stressed animals remained intact (S‐SH) or received enrichment (S‐EE) from postnatal day 22 for one month. Also, two groups received either saline (S‐SH‐S) or bicuculline (S‐SH‐B). One enriched group received muscimol (S‐EE‐M). The control groups were intact (C‐SH), enriched (C‐EE), or received bicuculline (C‐SH‐B) or saline (C‐SH‐S). We assessed learning and memory and, hippocampal long‐term potentiation (LTP). Serum corticosterone levels were detected as a measure of stress condition. We found that stress reduced spatial performance and suppressed LTP in the S‐SH animals. Postnatal enrichment restored both spatial learning and memory and synaptic plasticity in the S‐EE rats. GABAergic antagonism strengthens maze performance and LTP induction in the S‐SH‐B group. However, muscimol prevented the positive effects of enrichment in the S‐EE‐M animals. Environmental enrichment and GABAergic modulation may improve disrupted spatial performance and synaptic plasticity.

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Section: Discussionmentioning

confidence: 81%

“…GABA, the main inhibitory neurotransmitter of the brain, has an essential role in learning and memory processes (Bonansco & Fuenzalida, 2016) as well as synaptic plasticity (Kim, Son, et al, 2015). Plenty of GABAergic interneurons are nested in hippocampus (Somogyi & Klausberger, 2005).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission

Bidgoli

Salami

Talaei

2020

Intl J of Devlp Neuroscience

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“…Allopregnanolone is a positive modulator of GABAAR activity [ 5 ]. GABA is the primary inhibitory neurotransmitter in the brain and plays a vital role in learning and memory [ 46 ] and synaptic plasticity [ 47 ]. The hippocampus has numerous GABAA receptors that participate in molecular mechanisms of memory formation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome

et al. 2021

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Metabolic Syndrome (MetS) is considered a common disorder, especially with a sedentary lifestyle and unhealthy food consumption. Cognitive impairment is one of the MetS consequences that worsens the quality of life of the patients. The study aimed to assess the therapeutic effect of the neurosteroid Allopregnalonone on spatial memory and, therefore, the expression of two synaptic plasticity markers in the hippocampus. Thirty-two male rats were divided into four groups: control groups, MetS, and MetS + Allopregnalone. Spatial memory has been evaluated by the Y-maze task and blood pressure measured by the rat tail method. Biochemical evaluation of serum glucose, insulin, lipid profile, and hippocampal expression of Synaptophysin and Associated Protein 43 (GAP-43) were performed for assessing Allopregnanolone on serum and hippocampal markers. Allopregnanolone therapy improved working spatial memory, hypertension, and biochemical markers measured in the serum and hippocampus.

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“…The relative expression of genes was determined using the 2 -ΔΔct method with normalization to GAPDH expression. The primer sets used for D1R , D2R , GABA A R-α2 , GABA A R-α4 , GluR1 , GluR2 , NR2A, and NR2B were designed according to the publications ( Kim et al, 2010 , 2015 ; Zhou et al, 2016 ).…”

Section: Methodsmentioning

confidence: 99%

MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors

Zhang

Chen

et al. 2017

Front. Mol. Neurosci.

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Anxiety disorders commonly occur in Parkinson’s disease. Using field potential recording and patch-clamp recording, we evaluated influence of MPTP-reduced dopaminergic afferent in basolateral amygdala (BLA), a main region for affective regulation, on excitatory–inhibitory circuits and synaptic plasticity. Field excitatory post-synaptic potential (fEPSP) slopes at external capsule-BLA synapses were increased in MPTP-mice with decreases in paired-pulse facilitation and long-term potentiation amplitude, which were corrected by bath-application of D2R agonist quinpirole or cannabinoid type 1 receptors agonist WIN55,212-2, but not D1R agonist SKF38393. Compared to single waveform fEPSP in control mice, a multi-spike waveform fEPSP was observed in MPTP-mice with prolongation of duration and an increase in paired-pulse inhibition, which were recovered by BLA-injection of quinpirole for 2 days rather than bath-application. Density of GABA-evoked current (IGABA) in BLA principal neurons and GABAAR-α2 subunit expression were reduced in MPTP-mice, which were recovered by administration of quinpirole. Decline of PKC phosphorylation in BLA of MPTP-mice was corrected by bath-application of quinpirole, but not SKF38393. In MPTP-mice, BLA-injection of quinpirole or PKC activator PMA could recover GABAAR expression, which was sensitive to PKC inhibitor GF109203X. The impairment of long-term depression (LTD) in MPTP-mice was rescued by bath-application of GABAAR agonist muscimol or BLA-injection of quinpirole and PMA. Finally, BLA-injection of muscimol, quinpirole or PMA relieved anxiety-like behaviors in MPTP-mice. The results indicate that the MPTP-induced dopamine depletion in BLA principal neurons through reducing D2R-mediated PKC phosphorylation suppresses GABAAR expression and activity, which impairs GABAAR-mediated inhibition and LTD induction leading to anxiety-like behaviors.

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Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus

Cited by 16 publications

References 99 publications

Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission

Environmental enrichment restores impaired spatial memory and synaptic plasticity in prenatally stress exposed rats: The role of GABAergic neurotransmission

Effect of Allopregnanolone on Spatial Memory and Synaptic Proteins in Animal Model of Metabolic Syndrome

MPTP-Induced Dopamine Depletion in Basolateral Amygdala via Decrease of D2R Activation Suppresses GABAA Receptors Expression and LTD Induction Leading to Anxiety-Like Behaviors

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