Developmental and age-related changes in D1-dopamine receptors and dopamine content in the rat striatum

Giorgi, Osvaldo; Montis, Maria Graziella De; Porceddu, M.L.; Mele, S.; Calderini, G.; Toffano, G.; Biggio, Giovanni

doi:10.1016/0165-3806(87)90053-8

Cited by 168 publications

(56 citation statements)

References 32 publications

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“…In some reports, D 1 -like receptors increased steadily from birth to adulthood [Zeng et al, 1988;Murrin and Zeng, 1990;Leslie et al, 1991;Rao et al, 1991;Schambra et al, 1994]. In others, there was an increase to maximal levels after weaning, followed by pruning to adult levels [Giorgi et al, 1987;Gelbard et al, 1989;Teicher et al, 1995], and one study found no change over postnatal weeks 1-7 [Broaddus and Bennett, 1990]. These variable findings may reflect differences in specific experimental conditions or dissimilar developmental patterns of D 1 -like subtypes in subregions of forebrain.…”

Section: Introductionmentioning

confidence: 81%

Postnatal Development of Dopamine D<sub>1</sub>-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study

Tomasini²,

1999

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Postnatal development of dopamine D₁-like (D₁/D₅) receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), hippocampus, frontal and entorhinal cerebral cortex was assessed between postnatal days (PD) 7–60 by in vitro receptor autoradiography. Density of [³H]SCH-23390 binding to D₁-like receptors increased from PD-7 to a peak at PD-28 in CPu (11-fold) and NAc (23-fold), then declined by 20–40% in both regions over PD-35–60, to adult levels. In hippocampus, frontal and entorhinal cortex, D₁-like receptors increased by lesser amounts (3- to 4-fold) from PD-7 to stable, maximal adult levels at PD-60. Evidently, excess D₁-like receptors were eliminated during maturation of CPu and NAc, but not in the other forebrain regions. Postnatal D₁-like receptor development in rat forebrain paralleled that of D₂- and D₄-like receptors in the same regions.

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Section: Introductionmentioning

confidence: 81%

Postnatal Development of Dopamine D<sub>1</sub>-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study

Tomasini²,

1999

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“…This result is not consistent with previous data showing no significant effect of U exposure at a dose of 40 mg.L -1 on anxiety-like behavior in adult rats . We should bear in mind that the rat's biochemical system is not complete until 4 weeks after birth (Giorgi et al, 1987). This might explain the differences in some behavioral effects detected in rats exposed from birth or at adult age.…”

Section: Discussionmentioning

confidence: 99%

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

et al. 2015

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-In view of the known sensitivity of the developing central nervous system to pollutants, we sought to assess the effects of exposure to uranium (U) -a heavy metal naturally present in the environment -on the behavior of young rats and the impact of oxidative stress on their hippocampus. Pups drank U (in the form of uranyl nitrate) at doses of 10 or 40 mg.L -1 for 10 weeks from birth. Control rats drank mineral water. Locomotor activity in an open field and practice effects on a rotarod device decreased in rats exposed to 10 mg.L -1 (respectively, -19.4% and -51.4%) or 40 mg.L -1 (respectively, -19.3% and -55.9%) in compared with control rats. Anxiety (+37%) and depressive-like behavior (-50.8%) were altered by U exposure only at 40 mg.L -1 . Lipid peroxidation (+35%) and protein carbonyl concentration (+137%) increased significantly after exposure to U at 40 mg.L -1 . A significant increase in superoxide dismutase (SOD, +122.5%) and glutathione peroxidase (GPx, +13.6%) activities was also observed in the hippocampus of rats exposed to 40 mg.L -1 . These results demonstrate that exposure to U since birth alters some behaviors and modifies antioxidant status.

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“…The function of the additional VMAT-2 that emerges during development from postnatal day 40 to 90 is unknown; however, one function might be to sequester the larger dopamine content found in young adult versus adolescent rats (Nomura et al, 1976;Giorgi et al, 1987;Fig. 4) and thereby prevent its autoxidation, an effect that has been linked to the formation of reactive oxygen species (Cadet et al, 1994;Cubells et al, 1994;Yamamoto and Zhu, 1998).…”

Section: Discussionmentioning

confidence: 99%

Age-Dependent Methamphetamine-Induced Alterations in Vesicular Monoamine Transporter-2 Function: Implications for Neurotoxicity

Truong

Wilkins²,

Baudys

et al. 2005

J Pharmacol Exp Ther

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Tens of thousands of adolescents and young adults have used illicit methamphetamine. This is of concern since its high-dose administration causes persistent dopaminergic deficits in adult animal models. The effects in adolescents are less studied. In adult rodents, toxic effects of methamphetamine may result partly from aberrant cytosolic dopamine accumulation and subsequent reactive oxygen species formation. The vesicular monoamine transporter-2 (VMAT-2) sequesters cytoplasmic dopamine into synaptic vesicles for storage and perhaps protection against dopamine-associated oxidative consequences. Accordingly, aberrant VMAT-2 function may contribute to the methamphetamine-induced persistent dopaminergic deficits. Hence, this study examined effects of methamphetamine on VMAT-2 in adolescent (postnatal day 40) and young adult (postnatal day 90) rats. Results revealed that high-dose methamphetamine treatment caused greater acute (within 1 h) decreases in vesicular dopamine uptake in postnatal day 90 versus 40 rats, as determined in a nonmembrane-associated subcellular fraction. Greater basal levels of VMAT-2 at postnatal day 90 versus 40 in this purified fraction seemed to contribute to the larger effect. Basal tissue dopamine content was also greater in postnatal day 90 versus 40 rats. In addition, postnatal day 90 rats were more susceptible to methamphetamine-induced persistent dopaminergic deficits as assessed by measuring VMAT-2 activity and dopamine content 7 days after treatment, even if drug doses were adjusted for age-related pharmacokinetic differences. Together, these data demonstrate dynamic changes in VMAT-2 susceptibility to methamphetamine as a function of development. Implications with regard to methamphetamine-induced dopaminergic deficits, as well as dopamine-associated neurodegenerative disorders such as Parkinson's disease, are discussed.According to the Substance Abuse and Mental Health Services Administration for 2003 (2004), 1.3% of adolescents aged 12 to 17 and 5.2% of young adults aged 18 to 25 have used illicit methamphetamine (METH) at least once in their lifetime. This is of concern because it is well established that high-dose methamphetamine administrations lead to persistent dopaminergic deficits in rodents, nonhuman primates, and humans, as determined by measuring striatal dopamine levels, tyrosine hydroxylase activity, and dopamine transporter function days to months after treatment (Koda and Gibb, 1973;Wagner et al., 1980;Bennett et al., 1998;Schmidt et al., 1985;Seiden, 1985;Wilson et al., 1996).Most studies of methamphetamine and its actions have involved adult animal models. However, given the prevalence of methamphetamine use among young people, increasing attention has focused on effects of the stimulant in adolescent animal models. For example, Cappon et al. (1997) demonstrated that multiple high-dose administrations of methamphetamine reduce striatal dopamine levels in postnatal day 60, but not postnatal day 20, rats. Similarly, this highdose methamphetamine regimen lead...

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Developmental and age-related changes in D1-dopamine receptors and dopamine content in the rat striatum

Cited by 168 publications

References 32 publications

Postnatal Development of Dopamine D<sub>1</sub>-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study

Postnatal Development of Dopamine D<sub>1</sub>-Like Receptors in Rat Cortical and Striatolimbic Brain Regions: An Autoradiographic Study

Uranium modifies or not behavior and antioxidant status in the hippocampus of rats exposed since birth

Age-Dependent Methamphetamine-Induced Alterations in Vesicular Monoamine Transporter-2 Function: Implications for Neurotoxicity

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