Developmental Anatomy of Craniofacial Sutures

Rice, David

doi:10.1159/000115028

Cited by 95 publications

(115 citation statements)

References 53 publications

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“…In this study, a specific choice in the biochemical reaction term led to the formation of labyrinthic patterns that resembled sutures. Nevertheless, even though morphogens are determinants of embryonic suture development [2,9], mechanical forces have to be taken into account in order to explain how sutures grow after birth and develop their peculiar architecture [2]. Another morphogenetic model for sutures has been recently proposed [16] and involved 'viscous fingering' phenomena similar to those occurring between two immiscible liquids with different viscosities.…”

Section: Introductionmentioning

confidence: 99%

A mathematical model for mechanotransduction at the early steps of suture formation

Khonsari

Olivier²,

Vigneaux

et al. 2013

Proc. R. Soc. B.

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Growth and patterning of craniofacial sutures is subjected to the effects of mechanical stress. Mechanotransduction processes occurring at the margins of the sutures are not precisely understood. Here, we propose a simple theoretical model based on the orientation of collagen fibres within the suture in response to local stress. We demonstrate that fibre alignment generates an instability leading to the emergence of interdigitations. We confirm the appearance of this instability both analytically and numerically. To support our model, we use histology and synchrotron X-ray microtomography and reveal the fine structure of fibres within the sutural mesenchyme and their insertion into the bone. Furthermore, using a mouse model with impaired mechanotransduction, we show that the architecture of sutures is disturbed when forces are not interpreted properly. Finally, by studying the structure of sutures in the mouse, the rat, an actinopterygian (Polypterus bichir) and a placoderm (Compagopiscis croucheri), we show that bone deposition patterns during dermal bone growth are conserved within jawed vertebrates. In total, these results support the role of mechanical constraints in the growth and patterning of craniofacial sutures, a process that was probably effective at the emergence of gnathostomes, and provide new directions for the understanding of normal and pathological suture fusion.

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Section: Introductionmentioning

confidence: 99%

A mathematical model for mechanotransduction at the early steps of suture formation

Khonsari

Olivier²,

Vigneaux

et al. 2013

Proc. R. Soc. B.

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“…[26] In the skull (and probably in the shell of the turtle), sutures are not only articulations between bones, but also areas of osteogenesis, in which osteoprogenitor cells proliferate, differentiate, and allow bone growth. [27] Thus, the suture maintains a space between opposing bone margins so that they do not unite, and continued bone growth can occur. The growth of adjoining dermal bones Figure 1.…”

mentioning

confidence: 99%

“…In the human skull, suture closure occurs in early adulthood (25-30 years of age) for calvarial sutures, while facial sutures close only in late adulthood (7 th to 8 th decade of life). [27] However, it is not known when (if ever) the sutures of the shell of turtles close. We have found that the sutures were open in all the turtles examined, including large, fully mature turtles, which reached their adult size.…”

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confidence: 99%

Mechanical Function of a Complex Three‐Dimensional Suture Joining the Bony Elements in the Shell of the Red‐Eared Slider Turtle

et al. 2009

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“…In the developing calvarium, appositional bone growth increases bone thickness. 23 Disturbed appositional bone growth in HGPS has been suggested by the observation of laminations beneath the periosteum of long bones on radiographs. 13 A predisposition toward skull fractures has been reported in HGPS.…”

Section: Calvarial and Skull Base Changesmentioning

confidence: 99%

Craniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome

Ullrich

Silvera²,

Campbell

et al. 2012

AJNR Am J Neuroradiol

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SUMMARY: HGPS is a rare syndrome of segmental premature aging. Our goal was to expand the scope of structural bone and soft-tissue craniofacial abnormalities in HGPS through CT or MR imaging. Using The Progeria Research Foundation Medical and Research Database, 98 imaging studies on 25 patients, birth to 14.1 years of age, were comprehensively reviewed. Eight newly identified abnormalities involving the calvaria, skull base, and soft tissues of the face and orbits were present with prevalences between 43% and 100%. These included J-shaped sellas, a mottled appearance and increased vascular markings of the calvaria, abnormally configured mandibular condyles, hypoplastic articular eminences, small zygomatic arches, prominent parotid glands, and optic nerve kinking. This expanded craniofacial characterization helps link disease features and improves our ability to evaluate how underlying genetic and cellular abnormalities culminate in a disease phenotype. Children with HGPS typically appear healthy at birth and within the first year of life develop severe failure to thrive with sclerodermatous skin changes. 8,9 Classic craniofacial features develop with age and underlying disease culminates in death from myocardial infarction or stroke at an average age of 13 years. 8,10 Close examination of common and disparate findings in HGPS and aging may inform both fields of study. Clinical features that resemble premature aging include alopecia, joint contractures, progressive mandibular resorption, low bone density, lipoatrophy with limb wasting, and global atherosclerosis. 8,11 Age-related conditions such as Alzheimer disease, dementia, osteoarthritis, and cancer are absent. Cognitive function and motor development are normal. In addition, there is growth failure, skeletal dysplasia, and lack of pubertal development. ABBREVIATIONS 12Prior reports of craniofacial features are based on plain film findings and autopsy results. 10,13,14 In this study of a large cohort of patients with HGPS, we reviewed CT, MR imaging, and radiographs to quantify previously noted and new craniofacial imaging features to expand our understanding of the natural history of the disease. Materials and Methods Patients and DataPatients were identified from The Progeria Research Foundation Medical and Research Database (Brown University Center for Gerontology and Healthcare Research, Providence, Rhode Island). Eligible individuals had a genetic and/or clinical diagnosis of HGPS and at least 1 MR or CT of the head or neck available for review. The diagnosis of HGPS was genetically determined by either the classic exon 11 (c. 1824 CϾT) or a nonclassic progerin-producing LMNA mutation within exon 11 or the exon/intron border, plus the typical clinical phenotype. 15Data abstraction included indications for neuroimaging studies, OFC, and medications. Height-age was determined by using the CDC and WHO child growth standards for boys and girls. 16,17 Abstracted OFC measurements from patient charts were expressed as percentiles by height-age. Neuroimaging Stu...

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Developmental Anatomy of Craniofacial Sutures

Cited by 95 publications

References 53 publications

A mathematical model for mechanotransduction at the early steps of suture formation

A mathematical model for mechanotransduction at the early steps of suture formation

Mechanical Function of a Complex Three‐Dimensional Suture Joining the Bony Elements in the Shell of the Red‐Eared Slider Turtle

Craniofacial Abnormalities in Hutchinson-Gilford Progeria Syndrome

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