Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus

Degelmann, Adelheid; Hardy, P.; Perrimon, Norbert; Mahowald, Anthony P.

doi:10.1016/0012-1606(86)90268-x

Cited by 69 publications

(28 citation statements)

References 34 publications

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“…Although it is true that pole cells never form (and in fact, oocytes never fully develop) in the absence of vasa protein, the results with tudor and valois mutations demonstrate that the presence of wild-type vasa protein at the posterior pole of the embryo is itself not sufficient for the differentiation of pole cells. It is possible that the role of valois in pole cell formation is related to its role in somatic cellularization (Schfipbach andWieschaus 1986, 1989), and it is interesting that mutations in cappuccino (Manseau and Schfipbach 1989b), Bicaudal-C (this paper), and three terminal-group genes also give rise to general cellularization defects [fs(1)N, Degelmann et al 1985; fs(1)ph, Perrimon et al 1986;l(1)ph, Perrimon et al 1985].…”

Section: Genes and Development 915mentioning

confidence: 99%

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

Lasko

Ashburner²

1990

Genes Dev.

363

271

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The protein product of the Drosophila materual-effect posterior group gene vasa is localized to the posterior pole of the oocyte and is sequestered by the pole cells as they form. It is, however, present at easily detectable levels throughout the oocyte and pre-blastoderm embryo. The protein is present in the pole cells and their germ line derivatives throughout all stages of development. An antiserum against this protein recognizes a pole-ceUspecific antigen in seven other Drosophila species. Of six other materual-effect loci essential for embryonic pole cell development, none affects expression of vasa, mutations in four abolish vasa protein localization, and mutations in two, tudor and valois, have little, if any, effect on vasa expression or localization. This indicates that vasa protein, when properly localized, is not sufficient for induction of pole cell development, and that at least the tudor and valois wild-type functions are also required specifically for this process. These results are discussed with respect to the multiple functions of the vasa gene.

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Section: Genes and Development 915mentioning

confidence: 99%

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

Lasko

Ashburner²

1990

Genes Dev.

363

271

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“…The positional information along the anteroposterior axis that activates the zygotically acting segmentation genes is provided by a small number of maternal genes and deposited into the developing oocyte (N6sslein- Volhard et al 1982;Boswell and Mahowald 1985;Degelmann et al 1986;Frohnh6fer and Ntisslein-Volhard 1986;Lehmann and Niisslein-Volhard 1986;Schiipbach and Wieschaus 1986). For example, the maternal gene bridization to wild-type embryos and embryos of the various segmentation mutants (for a recent review, see Scott and O'Farrell 1986).…”

mentioning

confidence: 99%

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

Baumgärtner¹,

Bopp²,

Burri³

et al. 1987

Genes Dev.

213

131

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“…It should be mentioned that the phenotype of the intermingled pole cells resembles quite closely the pole-hole phenotype (e. g. f s(1)N211 embryos, Degelmann et al 1986). In fs(1)N211 embryos, however, posterior midgut invagination does not occur and moreover, as in the case of other grandchildlessknirps mutant embryos, posterior segment patterns are also damaged (see detailed discussion Mahowald and Hardy 1985).…”

Section: Discussionmentioning

confidence: 76%

Developmental analysis of grandchildless (gs(1)N441) mutation in Drosophila melanogaster; Abnormal formation of pole cells.

Niki

1988

The Japanese journal of genetics

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A detailed examination of the developmental features of abnormal formation of pole cells and a functional analysis of the germ plasm of gs(1)N441 embryos were carried out. The germ plasm is morphologically normal. Embryos in which cleavage nuclei show retarded migration to the posterior pole do not form pole cells. Pole cells, following formation, are abnormally segregated and then intermingled between the blastoderm cell layer but retaining normal morphology and differentiating into functional germ cells. The results of cytoplasmic transplantation experiments indicate the autonomous segregation ability of the mutant polar plasm to form pole cells to possibly be affected.

show abstract

Developmental analysis of the torso-like phenotype in Drosophila produced by a maternal-effect locus

Cited by 69 publications

References 34 publications

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development.

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

Developmental analysis of grandchildless (gs(1)N441) mutation in Drosophila melanogaster; Abnormal formation of pole cells.

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