Developmental Abnormalities of the Corpus Callosum in Schizophrenia

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

“…Taken together, AI and CSP findings are in line with several case series and other MRI qualitative investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia [25,33,35,36,64,66]. Findings of abnormalities in the midbrain are consistent both with the hypotheses concerning disruptions in the chemical anatomy of the brain [5] and with the notion of a deficit in midline regions that modulate information processing and attention [4,38].…”

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

“…Taken together, AI and CSP findings are in line with several case series and other MRI qualitative investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia [25,33,35,36,64,66]. Findings of abnormalities in the midbrain are consistent both with the hypotheses concerning disruptions in the chemical anatomy of the brain [5] and with the notion of a deficit in midline regions that modulate information processing and attention [4,38].…”

Neurodynamics of Abnormalities in Cerebral Metabolism and Structure in Schizophrenia

“…Nevertheless, such anomalies constitute circumstantial evidence for a programmed or exogenously determined disruption of cerebral morphogenesis. Furthermore, the instance of mild, partial agenesis of the corpus callosum complements other recent case reports of more prominent callosal agenesis in schizophrenia at a rate of occurrence considerably above chance levels (see Swayze et al 1990). Callosal agenesis, though extremely rare, is known to be associated with dysmorphogenesis of the limbic system (including hippocampus, parahippocampal and cingulate gyri, amygdala, septum, hypothalamus, and certain thalamic nuclei [see Atlas et al 1986]).…”

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

“…Taken together, the available morphological data indicate that changes in area and form of the CC in schizophrenics are merely symptomatic of changes in ventricular Jeeves and Temple, 1987 Jeeves and Temple, 1987Temple et al, 1989Temple et al, 1989 size and in limbic and temporal structures whose alterations are perhaps more directly associated with schizophrenia. Given the close anatomical relations, developmental abnormalities in the formation of the cingulate cortex and hippocampus might be reflected in ill-defined morphological alterations of the CC (Atlas et al, 1986;Swayze et al, 1990). This view is in agreement with the increasing number of observations linking developmental an omalies of the limbic cortices with schizophrenia ( Conrad and Scheibe!, 1987;Falkai and Bogerts, 1986;Jakoband Beckmann, 1989;Kovelman and Scheibe!, 1984).…”

“…Complete agenesis of the CC has been reported in one case of psychosis (Velek et al, 1988) and schizophrenia (Lewis et al, 1988), and partial agenesis in two other cases (Swayze et al, 1990). These Observations are in line with a long series of reports claiming morphological changes of the CC in schizophrenic persons Nasrallah et al, 1983;Rosenthai and Bigelow, 1972).…”

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

“…Taken together, AI and CSP findings are in line with several case series and other MRI qualitative investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia [25,33,35,36,64,66]. Findings of abnormalities in the midbrain are consistent both with the hypotheses concerning disruptions in the chemical anatomy of the brain [5] and with the notion of a deficit in midline regions that modulate information processing and attention [4,38].…”

Neurodynamics of Abnormalities in Cerebral Metabolism and Structure in Schizophrenia

“…Nevertheless, such anomalies constitute circumstantial evidence for a programmed or exogenously determined disruption of cerebral morphogenesis. Furthermore, the instance of mild, partial agenesis of the corpus callosum complements other recent case reports of more prominent callosal agenesis in schizophrenia at a rate of occurrence considerably above chance levels (see Swayze et al 1990). Callosal agenesis, though extremely rare, is known to be associated with dysmorphogenesis of the limbic system (including hippocampus, parahippocampal and cingulate gyri, amygdala, septum, hypothalamus, and certain thalamic nuclei [see Atlas et al 1986]).…”

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

“…Taken together, the available morphological data indicate that changes in area and form of the CC in schizophrenics are merely symptomatic of changes in ventricular Jeeves and Temple, 1987 Jeeves and Temple, 1987Temple et al, 1989Temple et al, 1989 size and in limbic and temporal structures whose alterations are perhaps more directly associated with schizophrenia. Given the close anatomical relations, developmental abnormalities in the formation of the cingulate cortex and hippocampus might be reflected in ill-defined morphological alterations of the CC (Atlas et al, 1986;Swayze et al, 1990). This view is in agreement with the increasing number of observations linking developmental an omalies of the limbic cortices with schizophrenia ( Conrad and Scheibe!, 1987;Falkai and Bogerts, 1986;Jakoband Beckmann, 1989;Kovelman and Scheibe!, 1984).…”

“…Complete agenesis of the CC has been reported in one case of psychosis (Velek et al, 1988) and schizophrenia (Lewis et al, 1988), and partial agenesis in two other cases (Swayze et al, 1990). These Observations are in line with a long series of reports claiming morphological changes of the CC in schizophrenic persons Nasrallah et al, 1983;Rosenthai and Bigelow, 1972).…”

Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study

“…Taken together, AI and CSP findings are in line with several case series and other MRI qualitative investigations that have shown a higher incidence of putatively developmental brain abnormalities in patients with schizophrenia [25,33,35,36,64,66]. Findings of abnormalities in the midbrain are consistent both with the hypotheses concerning disruptions in the chemical anatomy of the brain [5] and with the notion of a deficit in midline regions that modulate information processing and attention [4,38].…”

Neurodynamics of Abnormalities in Cerebral Metabolism and Structure in Schizophrenia

“…Nevertheless, such anomalies constitute circumstantial evidence for a programmed or exogenously determined disruption of cerebral morphogenesis. Furthermore, the instance of mild, partial agenesis of the corpus callosum complements other recent case reports of more prominent callosal agenesis in schizophrenia at a rate of occurrence considerably above chance levels (see Swayze et al 1990). Callosal agenesis, though extremely rare, is known to be associated with dysmorphogenesis of the limbic system (including hippocampus, parahippocampal and cingulate gyri, amygdala, septum, hypothalamus, and certain thalamic nuclei [see Atlas et al 1986]).…”

Genetically Defined Animal Models of Neurobehavioral Dysfunctions

“…Taken together, the available morphological data indicate that changes in area and form of the CC in schizophrenics are merely symptomatic of changes in ventricular Jeeves and Temple, 1987 Jeeves and Temple, 1987Temple et al, 1989Temple et al, 1989 size and in limbic and temporal structures whose alterations are perhaps more directly associated with schizophrenia. Given the close anatomical relations, developmental abnormalities in the formation of the cingulate cortex and hippocampus might be reflected in ill-defined morphological alterations of the CC (Atlas et al, 1986;Swayze et al, 1990). This view is in agreement with the increasing number of observations linking developmental an omalies of the limbic cortices with schizophrenia ( Conrad and Scheibe!, 1987;Falkai and Bogerts, 1986;Jakoband Beckmann, 1989;Kovelman and Scheibe!, 1984).…”

“…Complete agenesis of the CC has been reported in one case of psychosis (Velek et al, 1988) and schizophrenia (Lewis et al, 1988), and partial agenesis in two other cases (Swayze et al, 1990). These Observations are in line with a long series of reports claiming morphological changes of the CC in schizophrenic persons Nasrallah et al, 1983;Rosenthai and Bigelow, 1972).…”