Development study of pectin/Surelease® solid microparticles for the delivery of L-alanyl-L-glutamine dipeptide

Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: From pre-formulation to cytotoxicity in tissue-engineering oral mucosa

“…Systems composed of SO demonstrated the highest polydispersity index at time 0 due to its composition of a mixture of fatty acids (Rowe et al, 2009). This characteristic is not desirable since it represents low uniformity in droplet size (Nova et al, 2019;. At the end of these studies, the values decreased, which represents higher homogeneity of the droplet size.…”

“…The transmittance profiles and instability index (Ii) were obtained (Hou et al, 2010;Xu et al, 2017). For the morphological analysis, images were taken from an optical microscope (Kozo Optics) at 400x, where Feret's diameter (oil droplet size by the measurement of two tangents in opposite sides) was calculated from the measurement of approximately 800 droplets of oil phase for each formulation using Image Pro Plus 4 ® (Media Cybernetics, Inc., Rockville, USA) and droplet size distribution was estimated (Nova et al, 2019;Marcela B. Oliveira et al, 2018;Toledo Hijo et al, 2015;Tonon et al, 2011). For drug content of CUR in the emulgel, 1 g-formulations was dispersed in 5 ml of methanol, transferred to a 25 ml-volumetric flask and sonicated for 15 min in a sonicator waterbath (Unique ultra-cleaner 1400, Indaiatuba, Brazil).…”

A review on pectin extraction methods using lignocellulosic wastes

“…Since this method uses high temperatures for extraction, it can cause thermal degradation of some heat-sensitive compounds. The subcritical water extraction method requires simple equipment, so it is less expensive and fast [89].…”

Sustained Release Systems for Delivery of Therapeutic Peptide/Protein

“…132 For instance, in the work of Novaa et al, a combination of Surelease (ethylcellulose aqueous dispersion) and pectin was used to prepare microparticles (1.8−2.5 μm) via a spray drying technique and successfully loaded with AGP (L-alanyl-Lglutamine dipeptide), while the in vitro release of AGP did not extend distinctively probably due to the high hydrophilicity of the dipeptide. 133 In order to prolong the release of the laden proteins, Brandelli et al designed and prepared pectin and polygalacturonic acid-coated liposomes (∼120 nm) via the thin-film hydration method for more controllable and sustainable release of nisin. As expected, the in vitro release results indicated a reduced initial release of nisin from liposomes on the first 24 h from ∼80% to ∼40% owing to the coating of pectin and polygalacturonic acid, which provides a new long-acting formulation for antifungal application.…”

“…It is an emerging material for protein/peptide therapeutics owing to the high biocompatibility, biodegradability, and low toxicity . For instance, in the work of Novaa et al, a combination of Surelease (ethylcellulose aqueous dispersion) and pectin was used to prepare microparticles (1.8–2.5 μm) via a spray drying technique and successfully loaded with AGP ( l -alanyl- l -glutamine dipeptide), while the in vitro release of AGP did not extend distinctively probably due to the high hydrophilicity of the dipeptide . In order to prolong the release of the laden proteins, Brandelli et al designed and prepared pectin and polygalacturonic acid-coated liposomes (∼120 nm) via the thin-film hydration method for more controllable and sustainable release of nisin.…”