Development strategies of conducting polymer-based electrochemical biosensors for virus biomarkers: Potential for rapid COVID-19 detection

Tran, Vinh Van; Tran, Nhu Hoa Thi; Hwang, Hye Suk; Chang, Mincheol

doi:10.1016/j.bios.2021.113192

Cited by 70 publications

(43 citation statements)

References 212 publications

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“…Different materials have been combined to develop electrochemical biosensors, such as graphene oxide [30] , metal organic frameworks [31] , conducting polymers [32] , gold and silver nanoparticle [33] . Recently, Hashemi et al [34] related an electrochemical nanosensor based on activated graphene decorated with gold nanostars, capable to detect IgG antibodies against S1 protein of SARS-CoV-2 in human plasma samples.…”

Section: Introductionmentioning

confidence: 99%

“…Also, it has characteristic that are required for applications in biosensors, such as stability and high conductivity [ 38 , 41 , 47 , 48 ]. The sulfur atoms of thiophene rings in PEDOT structure can establish stable bonds with the AuNPs, due to the strong affinity between them [ 32 , 35 , 49 ]. The combination of these materials can be explored for different application, thanks to the synergism of the CPs high surface area with the electrical conductivity that comes from AuNPs.…”

Section: Introductionmentioning

confidence: 99%

“…The combination of these materials can be explored for different application, thanks to the synergism of the CPs high surface area with the electrical conductivity that comes from AuNPs. These features result in higher sensitivity and selectivity, lower detection limits and good reproducibility and stability for sensor and biosensor applications [ 32 , 50 ]. Furthermore, both materials are biocompatible, establishing an interface for immobilizing the different biological components, such as disease specific antigens, being a useful method to investigate associated biomarkers [ 32 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

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PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies

Lorenzen

Santos

et al. 2022

Electrochimica Acta

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Electrochemical sensors and biosensors are useful techniques for fast, inexpensive, sensitive, and easy detection of innumerous specimen. In face of COVID-19 pandemic, it became evident the necessity of a rapid and accurate diagnostic test, so the impedimetric immunosensor approach can be a good alternative to replace the conventional tests due to the specific antibody-antigen binding interaction and the fast response in comparison to traditional methods. In this work, a modified electrode with electrosynthesized PEDOT and gold nanoparticles followed by the immobilization of truncated nucleoprotein (N aa160-406aa) was used for a fast and reliable detection of antibodies against COVID-19 in human serum sample. The method consists in analyzing the charge-transfer resistance (R CT ) variation before and after the modified electrode comes into contact with the positive and negative serum sample for COVID-19, using [Fe(CN) 6 ] 3-/4− as a probe. The results show a linear and selective response for serum samples diluted in a range of 2.5 × 10 3 to 20 × 10 3 . Also, the electrode material was fully characterized by Raman spectroscopy, transmission electron microscopy and scanning electron microscopy coupled with EDS, indicating that the gold nanoparticles were well distributed around the polymer matrix and the presence of the biological sample was confirmed by EDS analysis. EIS measurements allowed to differentiate the negative and positive samples by the difference in the R CT magnitude, proving that the material developed here has potential properties to be applied in impedimetric immunosensors for the detection of SARS-CoV-2 antibodies in about 30 minutes.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies

Lorenzen

Santos

et al. 2022

Electrochimica Acta

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“…10 Recently, development of biosensor for SARS-CoV-2 detection have gained enormous attractions. 11,12 Nanoscale materials have unique properties that make them especially useful to build the biosensors for biomedical diagnostic applications. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics.…”

Section: Introductionmentioning

confidence: 99%

Rapid, amplification-free and high-throughput SARS-CoV-2 RNA detectionviaa reduced-graphene-oxide based fluorescence assay

et al. 2022

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“…Conducting polymers have been commonly used as electrocatalysts and photocatalysts as promising alternatives to traditional inorganic semiconductors in various applications (i.e., energy storage, sensors, and environmental protection) because of their superior photocatalytic activities, good conductivities, and unique electrochemical and optical properties [ 13 , 14 , 15 ]. Techniques for the preparation of conducting polymers are also simple and easy to scale up for large-scale production by using chemical or electrochemical approaches.…”

Section: Introductionmentioning

confidence: 99%

Advanced Photocatalysts Based on Conducting Polymer/Metal Oxide Composites for Environmental Applications

Tran

Jung

et al. 2021

Polymers

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Photocatalysts provide a sustainable method of treating organic pollutants in wastewater and converting greenhouse gases. Many studies have been published on this topic in recent years, which signifies the great interest and attention that this topic inspires in the community, as well as in scientists. Composite photocatalysts based on conducting polymers and metal oxides have emerged as novel and promising photoactive materials. It has been demonstrated that conducting polymers can substantially improve the photocatalytic efficiency of metal oxides owing to their superior photocatalytic activities, high conductivities, and unique electrochemical and optical properties. Consequently, conducting polymer/metal oxide composites exhibit a high photoresponse and possess a higher surface area allowing for visible light absorption, low recombination of charge carriers, and high photocatalytic performance. Herein, we provide an overview of recent advances in the development of conducting polymer/metal oxide composite photocatalysts for organic pollutant degradation and CO2 conversion through photocatalytic processes.

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Development strategies of conducting polymer-based electrochemical biosensors for virus biomarkers: Potential for rapid COVID-19 detection

Cited by 70 publications

References 212 publications

PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies

PEDOT-AuNPs-based impedimetric immunosensor for the detection of SARS-CoV-2 antibodies

Rapid, amplification-free and high-throughput SARS-CoV-2 RNA detectionviaa reduced-graphene-oxide based fluorescence assay

Advanced Photocatalysts Based on Conducting Polymer/Metal Oxide Composites for Environmental Applications

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