Development of β-TCP-Ti6Al4V structures: Driving cellular response by modulating physical and chemical properties

Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo

“…Studies to analyze the effect of different titanium implant surface modifications on in vitro osteogenesis were conducted using various mammalian cell lines, such as MSCs or murine calvarial (pre)osteoblasts. 48,[61][62][63][64][65][66][67][68] As summarized in Table 2, the majority of the reviewed studies used disc 69,48,[61][62][63][64]70,71,65 or rectangular 66,72,67 shaped titanium implants with varying surface modifications, for example, gritblasting, magnetron sputtering or acidic treatment.…”

Multi-material NiTi-PEEK hybrid cellular structures by Selective Laser Melting and Hot Pressing: Tribological characterization

“…Metals, such as Ti6Al4V, have been historically used as orthopedic implant materials, once they meet satisfactorily with some of these requirements in terms of mechanical strength, high corrosion resistance and biocompatibility [1,[5][6][7][8]. However, improvements are still needed to enhance their overall performance once implant loosening often occurs, consequently leading to revision surgeries [4,[9][10][11]. The high elastic modulus and poor wear resistance of Ti6Al4V, besides a non-uniform contact between implant and bone are the three main factors accountable for implants failure [7,9,10].…”

“…However, improvements are still needed to enhance their overall performance once implant loosening often occurs, consequently leading to revision surgeries [4,[9][10][11]. The high elastic modulus and poor wear resistance of Ti6Al4V, besides a non-uniform contact between implant and bone are the three main factors accountable for implants failure [7,9,10].…”

Additive manufacturing of NiTi-Ti6Al4V multi-material cellular structures targeting orthopedic implants

“…However, in several applications such as orthopedic implants, components should incorporate distinct materials in different beneficial positions for achieving high-efficient and long-term solutions [38,39] . Several studies have been reported involving the SLM production of Ti6Al4V dense or cellular structures parts and some on Ti6Al4V-based multi-material structures [11,[40][41][42][43][44] . Some studies can be found in literature where AM is used to fabricate multimaterial Ti6Al4V-based components such as Ti6Al4V-Invar, Ti6Al4V-Stainless Steel, Ti6Al4V-Inconel 718, Ti6Al4V-Al12Si [36,[45][46][47] .…”