Development of vaccines against African swine fever virus

Sánchez, Elena González; Pérez-Núñez, Daniel; Revilla, Yolanda

doi:10.1016/j.virusres.2019.03.022

Cited by 91 publications

(79 citation statements)

References 60 publications

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“…Different from the previous method to make ASFV phylogenetic trees (14,17), we built the tree through doing multiple alignment in genomic scale to better understand the processes and patterns of evolution (44). The tree we made (Figure 4) is in consistent with previous publications (17,42,45). It reflects transmission events in the spread of ASFV.…”

Section: Resultssupporting

confidence: 89%

ASFVdb: An integrative resource for genomics and proteomics analyses of African swine fever

Zhu

Meng

2019

Preprint

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AbstractThe recent outbreaks of African swine fever (ASF) in China and Europe have threatened the swine industry globally. To control the transmission of the African swine fever virus (ASFV), we developed ASFVdb, the African swine fever virus database, an online data visualization and analysis platform for comparative genomics and proteomics. On the basis of known ASFV genes, ASFVdb reannotates the genomes of every strain and annotates 4833 possible ORFs. Moreover, ASFVdb performs a thorough analysis of the population genetics of all the published genomes of ASFV strains and performs functional and structural predictions for all genes. For each ASFV gene, visitors can obtain not only basic information of the gene but also the distribution of the gene in strains, conserved or high mutation regions, possible subcellular location of the gene and topology of the gene. In the genome browser, ASFVdb provides sliding window population genetics analysis results, which facilitate genetics and evolutional analyses at the genomic level. The web interface is constructed based on SWAV 1.0. ASFVdb is freely accessible at http://asfvdb.popgenetics.net.

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Section: Resultssupporting

confidence: 89%

ASFVdb: An integrative resource for genomics and proteomics analyses of African swine fever

Zhu

Meng

2019

Preprint

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“…This work provides some insights into the prevention and control of the ASFVs. Since the virus can rapidly change its phenotypes, such as the antigen, traditional methods of developing vaccines or drugs may be ineffective, as was demonstrated in previous studies (Escribano et al, 2013;Arabyan et al, 2018;Sanchez et al, 2019). Identification of the conservative antigenic epitopes or drug targets may help for development of effective vaccines and drugs.…”

Section: Discussionmentioning

confidence: 96%

Homologous recombination shapes the genetic diversity of African swine fever viruses

Zhu

Xiao

Fan

et al. 2019

Veterinary Microbiology

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A B S T R A C TThe African swine fever virus (ASFV) has severely influenced the swine industry of the world. Currently, there is no effective vaccine or drugs against the ASFV. How to effectively control the virus is challenging. In this study, we have analyzed all the publicly available ASFV genomes and demonstrated that there was a large genetic diversity of ASFV genomes. Interestingly, the genetic diversity was mainly caused by extensive genomic insertions and/or deletions (indels) instead of the point mutations. Further analyses showed that the indels may be attributed much to the homologous recombination, as supported by significant associations between the occurrence of extensive recombination events and the indels in the ASFV genomes. Besides, the homologous recombination also led to changes of gene content of ASFVs. Finally, repeated elements of dozens of nucleotides in length were observed to widely distribute and cluster in the adjacent positions of ASFV genomes, which may facilitate the occurrence of homologous recombination. This work highlighted the importance of homologous recombination in shaping the genetic diversity of the ASFVs, and could help understand the evolution of the virus.

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“…African swine fever (ASF), caused by the African swine fever virus (ASFV), remains one of the most dangerous infectious diseases of pigs and presents an urgent problem, mainly due to its impact on the global economy and welfare of pigs around the world. Today, in the light of numerous failures in developing an effective vaccine against ASF, prevention is mainly based on biosecurity measures together with the efficient work of veterinary services [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…The Veterinary Services take advantage of these observations in case of an ASF outbreak. Moreover, identified in the future, low virulent, naturally attenuated isolates may be crucial for vaccine development [3,9]. Therefore, studies of the biological properties of ASFV strains are still necessary.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

et al. 2020

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This paper was aimed to characterize clinical signs and pathomorphological lesions in twenty-two pigs, infected intranasally by different doses of African swine fever virus (Pol18_28298_O111), isolated during the outbreak in a pig farm that occurred in Eastern Poland throughout 2018. This article also attempts to indicate risk, related to virus load and shedding, and present possible difficulties with proper disease recognition at the farm level. The results revealed that even a very low dose (5 HAU) may initiate the infection. Various forms of the disease (acute, subacute, and chronic), mainly with prodromal clinical signs like fever, apathy, and reduced feed intake were observed. The most frequently observed lesions (82%) were: hyperemia and enlargement of lymph nodes and splenomegaly. The minimal incubation period was estimated at five days post-infection (dpi). Mortality ranged from 80–100%. Two pigs survived the infection. Some viremic animals presented delayed fever. In some cases, the fever was not detectable. Shortly after viremia, the virus was secreted ion the urine, feces, and saliva. The highest levels of virus were found in the internal organs and blood; however in the case of one pig (chronic form), viral DNA was not detected in the spleen, liver, bone marrow, and brain. Veterinary diagnosis may be difficult, and the final results should always be based on laboratory investigations.

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Development of vaccines against African swine fever virus

Cited by 91 publications

References 60 publications

ASFVdb: An integrative resource for genomics and proteomics analyses of African swine fever

ASFVdb: An integrative resource for genomics and proteomics analyses of African swine fever

Homologous recombination shapes the genetic diversity of African swine fever viruses

Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

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