Development of two spectrophotometric methods for quantification of certain anti-depressant drug in pure, pharmaceutical formulation and application to content uniformity testing

Atia, Noha N.; Marzouq, Mostafa A.; Hassan, Ahmed I.; Eltoukhi, Walid E.

doi:10.1016/j.microc.2019.03.093

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Moreover, this ECL approach can be considered as an attractive alternative to HPLC methods for quality control laboratories. Fluorimetry NQS [a] 0.2-1.2 0.01 [17] Fluorimetry Hantzsch reaction 0.05-0.5 8.5 × 10 À 3 [18] Colorimetry DMAB [b] 20-200 4.4 [19] Colorimetry TCBQ [c] 50-400 10.6 [19] UV photometry UV Derivative 2.0-12 0.08 [20] LC RP-HPLC [d] with UV 1.0-20 0.06 [20] LC [g] HPLC with UV 0.05-1.2 0.05 [21] Voltammetry DPV and SWV [e] 1.48-222 8.1 × 10 À 3…”

Section: Discussionmentioning

confidence: 99%

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Halawa

Saqib

2023

ChemistrySelect

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Electrochemiluminescence (ECL) has emerged as a powerful tool in bioassays due to its unique versatility and controllability, but it is still a challenge to amplify ECL signals without utilizing complex synthetic processes, sophisticated nanomaterials, and catalysts. Herein, a new ECL system with high sensitivity and selectivity is reported for the detection of amisulpride (AMS). The AMS was beneficial for enhancing the weak ECL emission of luminol, wherein co‐reaction effect of AMS promoted the generation of superoxide anion radicals (O2⋅−), which significantly improved the ECL efficiency of luminol (emitter). Under the optimized experimental conditions, this anodic ECL system achieved AMS detection (a biphasic curve) with linear concentration ranges of 0.2–5.0 μm and 5.0–100.0 μm. Impressively, the developed system exhibited a low limit of detection (LOD) and quantification (LOQ) of 10.2 nm and 50.5 nm for AMS, respectively. This luminol‐based ECL system is further applied for sensitive AMS detection in real (bulk) drug and pharmaceutical tablet form. Moreover, statistical comparison between the developed and comparison method showed good precision and accuracy of the developed method.

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Section: Discussionmentioning

confidence: 99%

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Halawa

Saqib

2023

ChemistrySelect

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“…There are many techniques for the determination of amisulpride including spectrophotometric (4)(5)(6)(7)(8)(9)(10)(11)(12) , elictrocimical (13)(14)(15) and Chromatographic methods (16)(17)(18)(19)(20) . The aim from this work is the development of two spectrophotometric methods that are simple, sensitive and accurate to assay of amisulpride in bulk dosage forms and tablet.…”

Section: Sketch 1: the Chemical Structure Of Amisulpridementioning

confidence: 99%

Spectrophotometric Determination of Amisulpride in Tablets by Diazotization Coupling Reactions

NAKTEL,

Z. AL ABDALI

2023

MINAR Journal

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A simple and sensitive spectrophotometric methods for assay of amisulpride in pure form and tablets is achieved. Both methods involves the diazotization of amisulpride with nitrite in an acidic medium to produce the corresponding diazonium salt, followed by either coupling with iminodibenzyl (IDB) in acidic medium to give a violet azo dye which showed maximum absorption at 558 nm (method A) or coupling with 7-iodo-8-hydroxyquinoline-5- sulfonic acid (IHQS) in alkaline medium to produce a red azo dye which show maximum absorbance at 522 nm (method B). The two methods have been applied successfully to determine of amisulpride in tablets and also evaluated by applying the standard addition technique

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“…MCN is a norepinephrine and serotonin reuptake inhibitor, for cure of depression and fibromyalgia [2]. Several analytical assays were described for the detection of selected drug such as spectrophotometric [4][5][6][7][8], Spectrofluorimetric [9,10], HPLC [11,12], HPTLC [15][16][17]. From the reported methods we found that there is a method has been described for determination of MCN which depends on measurement of the absorbance of cited drug solution at the cutoff point of many solvents 220 nm, which limits the methods selectivity [18].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, chromatographic methods required sophisticated instrumentation, consuming large volumes of organic solvents which elevate the cost and have bad impact on the environment. The described assay aims to develop accurate simple, sensitive procedure for the detection of MCN in bulk and dosage forms using spectrophotometric technique by utilizing readily available chemical coupling p-dimethylaminobenzal-dehyde, which has been successfully utilized for spectrophotometric detection of many raw materials [20][21][22][23]. The described assay depends on measuring the absorbance intensity of the resulting product at 400 nm, it was validated according to ICH recommendations [24], in addition, it has been used for content uniformity testing of the studied tablet preparations according to USP guidelines [25].…”

Section: Introductionmentioning

confidence: 99%

Utility of Chromogenic Properties of P-Dimethylaminobenzaldehyde for Determination of Certain Anti-Depressant Drug in Bulk, Pharmaceutical Preparation and Application to Tablets Uniformity Testing

WE,

RE,

et al. 2023

austinjbiosensbioelectron

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Simple, sensitive, accurate, and precise spectrophotometric assay has been developed and validated for the determination of selected anti-depressant drug namely; Milnacipran HCl (MCN) in pure form and pharmaceutical formulation. The method was based on the reaction of methanolic solution of selected anti-depressant drug with p-dimethylaminobenzaldehyde in acidic medium which give yellow product that can be determined at λex = 400 nm. The optimization of the reaction conditions such as the type of solvents, reagent concentration and reaction time were investigated. Under the optimum conditions, beer’s law is obeyed in the concentration range 60-300 μg mL-1, with good correlation coefficient (r² ≥ 0.998) and with a standard deviation (RSD% ≤ 0.0095). The limits of detection & the limits of quantification were found to be 13.1 and 40.0 μg mL-1, respectively. A Job’s plot of the absorbance versus the molar ratio of MCN to p-dimethylaminobenzaldehyde under consideration indicated (1:1) ratio. The method were successfully applied to the determination of MCN in its pharmaceutical formulation and the results obtained by the proposed method for the pure MCN and commercial tablets agreed well with those obtained by the reported method.

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Development of two spectrophotometric methods for quantification of certain anti-depressant drug in pure, pharmaceutical formulation and application to content uniformity testing

Cited by 5 publications

References 12 publications

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Spectrophotometric Determination of Amisulpride in Tablets by Diazotization Coupling Reactions

Utility of Chromogenic Properties of P-Dimethylaminobenzaldehyde for Determination of Certain Anti-Depressant Drug in Bulk, Pharmaceutical Preparation and Application to Tablets Uniformity Testing

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