Development of three-dimensional piezoelectric polyvinylidene fluoride-graphene oxide scaffold by non-solvent induced phase separation method for nerve tissue engineering

Abzan, Nadia; Kharaziha, Mahshid; Labbaf, Sheyda

doi:10.1016/j.matdes.2019.107636

Cited by 95 publications

(48 citation statements)

References 78 publications

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“…The cells cultured on P2S1, 1X demonstrated the highest proliferative capacity, and more concentration of NPs can be cytotoxic. Optical Density values show that by the addition of TiO 2 /CIP up to the concentration of 1.9 mg mL −1 the proliferation of L292 cells increases since TiO 2 form higher beta phase crystalline structure of the nanofibers …”

Section: Resultssupporting

confidence: 62%

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Ansarizadeh

Haddadi

Amini

et al. 2020

J of Applied Polymer Sci

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Electrospinning is an economical and alluring method to fabricate wound dressing mats from a variety of natural and synthetic materials. In this study, polyvinylidene fluoride (PVDF) and starch composite mats containing ciprofloxacin (CIP) loaded on titanium dioxide nanoparticles (TiO 2 ) were prepared. Fourier Transform Infrared spectra of CIP, synthesized TiO 2 NPs, TiO 2 /CIP, and PVDF/starch composite mats are analyzed. Scanning electron microscopy images revealed that the fiber diameter of PVDF nanofibers thickens by increasing starch, which varies between 180 nm and 550 nm. Strain at break of PVDF, starch, PVDF/starch (2:1 w:w; P2S1), PVDF/starch (1:1 w:w; P1S1), PVDF/starch (1:2 w:w; P1S2), and nanofibers were 103 AE 11, 3 AE 0.6, 27 AE 4, 52 AE 5.2, 7.7 AE 1%, respectively. Based on strain at break and young modulus, P2S1 was selected as a suitable candidate for wound dressing to which load TiO 2 / CIP as a bioactive agent. The release rate of CIP showed that about 40% of the drug is released in the first 2 days. Furthermore, the antibacterial activity of dressings was investigated using Escherichia coli and Staphylococcus aureus microorganisms and zones of clearance were obvious around the specimen on the agar plate.

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Section: Resultssupporting

confidence: 62%

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Ansarizadeh

Haddadi

Amini

et al. 2020

J of Applied Polymer Sci

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“…This has been similarly reported in a recent study by Abzan et al, which concluded that enhanced elastic modulus of graphene-based scaffolds is greatly depended on dispersion of GO nanosheets in the composite matrix. 49 Our results reveal that the mechanical characteristics of GO/ Na-ALG and rGO/Na-ALG scaffolds can be adjusted by controlling the GO concentration or graphene/alginate ratio. In addition, the nervous system tissue has a unique mechanical characteristic that meaningfully affects neural cell behaviour and tissue regeneration.…”

Section: Mechanical Propertiesmentioning

confidence: 76%

Advancing fabrication and properties of three-dimensional graphene–alginate scaffolds for application in neural tissue engineering

et al. 2019

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“…Poled PVDF 2-3 mV Potential generation when vibrated at 1200 Hz Enhanced neurite outgrowth using Nb2a cells [33] GO nanosheets/PVDF Enhanced β-phase, superior hydrophilicity, electromechanical and piezoelectric properties Higher PC12 cells activity [34] Positively poled P(VDF-TrFE) High piezoresponse in response to slight mechanical deformations…”

Section: Nerve Regenerationmentioning

confidence: 99%

“…Nerve conduits can be prepared from GO nanosheets/PVDF nanocomposites which markedly enhance attachment and proliferation of PC12 cells compared to PVDF scaffolds. [34] To obtain a homogeneous dispersion, functionalization of GO is necessary. Biosynthetic nerve conduits prepared from electrospun single walled carbon nanotubes (SWNTs)/silk fibroin (SF)/fibronectin (FN) nanocomposites, led to functional recovery of rat sciatic nerve defects by regenerating myelinated axons after 5 weeks of implantation.…”

Section: (15 Of 22)mentioning

confidence: 99%

Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration

Kapat

Shubhra

Zhou

et al. 2020

Adv Funct Materials

282

199

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Among various classes of biomaterials, the majority of non-centrosymmetric crystalline materials exhibit piezoelectric properties, i.e., the accumulation of charge in response to applied mechanical stress or deformation. Due to the growing interest in nanomaterials, piezoelectric nano-biomaterials have been widely investigated, leading to remarkable advancements throughout the last two decades. Piezoelectric properties, high surface energy, targeting properties, and intricate cell-material interactions render piezoelectric nanomaterials highly attractive for application in therapeutics as well as regenerative medicine. Herein, the major focus is to highlight the wide range of applications of piezoelectric nano-biomaterials in drug delivery, theranostics, and tissue regeneration. After a brief introduction to piezoelectricity, an overview is provided on the major classes of piezoelectric biomaterials as well as a description of the origin of biopiezoelectricity in different tissues and macromolecules. Subsequently, relevant properties and postfabrication strategies of nanostructured piezoelectric biomaterials are discussed aiming to maximize piezoresponse. Finally, recent studies on nano-piezoceramics and piezopolymers are presented, with specific focus on barium titanate, zinc oxide, and polyvinylidene fluoride.

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Development of three-dimensional piezoelectric polyvinylidene fluoride-graphene oxide scaffold by non-solvent induced phase separation method for nerve tissue engineering

Cited by 95 publications

References 78 publications

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Advancing fabrication and properties of three-dimensional graphene–alginate scaffolds for application in neural tissue engineering

Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration

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Development of three-dimensional piezoelectric polyvinylidene fluoride-graphene oxide scaffold by non-solvent induced phase separation method for nerve tissue engineering

Cited by 95 publications

References 78 publications

Sustained release of CIP from TiO2‐PVDF/starch nanocomposite mats with potential application in wound dressing

Sustained release of CIP from TiO2‐PVDF/starch nanocomposite mats with potential application in wound dressing

Advancing fabrication and properties of three-dimensional graphene–alginate scaffolds for application in neural tissue engineering

Piezoelectric Nano‐Biomaterials for Biomedicine and Tissue Regeneration

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Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing

Sustained release of CIP from TiO₂‐PVDF/starch nanocomposite mats with potential application in wound dressing